Targeting signaling pathways involved in primordial follicle growth or dormancy: potential application in prevention of follicular loss and infertility

New Paper by USERN Interest Group

🌀Premature ovarian failure (POF) is one of the important causes of infertility in females. To date, no efficient preventive pharmacological treatment has been offered to prevent POF.

🌀Therefore, it is necessary to focus on strategies that provide a normal reproductive lifespan to females at risk of developing POF.

Source: https://doi.org/10.1080/14712598.2022.2086042

@niima_usern

The role of Toll-like receptors and neuroinflammation in Parkinson’s disease

New Paper by USERN Interest Group

🌀Although the presence of inflammation in acute phases of PD might have protective effects concerning the clearance of α-synuclein and delaying the disease advancement, the chronic activation of TLRs and neuroinflammation might lead to neurodegeneration, resulting in the disease progression. 

🌀This article aimed to review additional evidence of the contribution of TLRs and neuroinflammation to PD pathogenesis, with the hope that TLRs could serve as novel disease-modifying therapeutic targets in PD patients in the future.

Source: https://doi.org/10.1186/s12974-022-02496-w

@niima_usern

Investigation of BRCAness associated miRNA-gene axes in breast cancer: cell-free miR-182-5p as a potential expression signature of BRCAness

New Paper by CIP Members

🔷The concept of the ‘BRCAness’ phenotype implies the properties that some sporadic breast cancers (BC) share with BRCA1/2-mutation carriers with hereditary BC.

🔷The current study aims to evaluate the expression level of some critical miRNAs-mRNA axes in HRR pathway in tumors and plasma samples from BC patients. 

🔷Our results highlight the difference between TNBC and non-TNBC tumor subgroups regarding the dysregulation of the key miRNA/mRNA axes involved in the HRR pathway. Also, for the first time, we show that the level of cell-free miR-182-5p in plasma samples from BC patients could be a clue for screening BC patients eligible for receiving PARP inhibitors through a personalized manner.

For more: https://doi.org/10.1186/s12885-022-09761-4

@cip_usern
@usern_net
@usern_intgrp

Prospect of exosomal circular RNAs in breast Cancer: presents and future

New paper by CIP Members

🔹Implementing precision oncology for breast cancer (BC) is a critical method for improving patient outcomes, which relies on the use of reliable biomarkers.

🔹Exosomes represent a potential alternative for the diagnosis and therapy of BC, As a “liquid biopsy” and a novel source for biomarkers.

🔹Circular RNAs (circRNAs) were recently revealed as a looping subclass of competing endogenous noncoding RNAs (ceRNAs) capable of microRNA sponging to regulate gene expression.

🔹CircRNAs are abundant in exosomes, according to various studies, and exosomal circRNAs (exo-circRNAs) play a significant role in cancer biology.

🔹Exo-circRNAs can be picked up by nearby or distant cells, affecting many features of the target cells’ pathophysiological states, thus boosting cell communication and tumor spread.

For more: https://link.springer.com/article/10.1007/s11033-022-07472-4


@cip_usern
@usern_net
@usern_intgrp

The role of epigenetic modifications in drug resistance and treatment of breast cancer

New Paper by USERN Interest Group

🌀It has recently been reported that epigenetic processes such as DNA methylation and histone modification, as well as microRNAs (miRNAs), have potently contributed to the pathophysiology, diagnosis, and treatment of breast cancer.

🌀Herein we discuss the molecular and epigenetic mechanisms underlying breast cancer progression and resistance as well as various aspects of epigenetic-based therapies as monotherapy and combined with immunotherapy.

Source: https://doi.org/10.1186/s11658-022-00344-6

@niima_usern

تاک اسکول: بزرگ ترین رویداد آموزش سخنرانی یوسرن✨

مدرسه سخنرانی یوسرن رویداد تخصصی شش روزه در حوزه سخنرانی است.

در این رویداد زیر نظر مدرسان مطرح کشوری آموزش دیده و مهارت های سخنوری خود را ارتقا می‌دهید.

📝 سرفصل های مدرسه سخنرانی:

✔️ History and models of talks
✔️ Story telling and writing scenarios
✔️ Data visualization and concept mapping
✔️ Stage management
✔️ Presentation skills
✔️ چگونه بهتر حرف بزنیم؟
✔️ اصول و مبانی گویندگی و اجرا
✔️ در آشپزخانه تولید محتوا
✔️ فن بيان، كنترل صدا و نقطه طلايى صدا


❇️ علاوه بر آموزش، یادگیری و تعامل با اساتید می‌توانید سخنرانی های سومین مرحله رقابت مینیاتورتاک ۲۰۲۲ را با توجه به مطالبی که آموختید داوری کنید.

💳 سرتیفیکیت: سرتیفیکیت شرکت در رویداد، از طرف یوسرن اعطا خواهد شد.

⏰ زمان: یکم تا ششم مرداد

📍مکان: تهران، انتهای بلوار کشاورز، مرکز طبی کودکان

❓اطلاعات بیشتر و ثبت نام
https://evand.com/events/usern-talkschool

+ سوالات متداول را از اینجا ببینید.

+ با ما از طریق آیدی تلگرام زیر در ارتباط باشید:
@MTalk_USERN

@usern_net

We are delighted to share the last comprehensive review paper, Commercialization and regulation of regenerative medicine products: Promises, advances and challenges, published in Biomedicine & Pharmacotherapy.

We discussed in this paper on regenerative medicine products, emphasizing that:

• All efforts in regenerative medicine must proceed through in silico, in vitro, in vivo, and clinical trials before they can move from the bench to the bedside.

• Due to extensive regulations, principles, and financial requirements, a few regenerative medicine products have been commercialized.

• Various monitoring centers promote the evaluation and commercialization of these products under design control procedures.

• This comprehensive review includes the development, processes, regulatory concerns, and immunological considerations of regenerative medicine.

Find the open access full text from:

https://lnkd.in/e3gDerHg


@Usern_Remed

@USERN_net

#PPIG_PAPER
چاپ مقاله فیتوفارماکولوژی با عنوان
A literature review of the studies concerning selected plant-derived adaptogens and their general function in body with a focus on animal studies

در مجله
Phytomedicine
با ایمپکت فاکتور ۶.۶۵۶

مقالات ما را با هشتگ
#PPIG_PAPER

در کانال عمومی تلگرام و صفحه اینستاگرام فیتوفارماکولوژی دنبال کنید.

https://www.sciencedirect.com/science/article/abs/pii/S0944711322004330

@ppigpublicity

#PPIG_PAPER

چاپ مقاله با همکاری گروه فیتوفارماکولوژی با عنوان

Scientometric assessment of scientific documents published in 2020 on herbal medicines used for COVID-19

در مجله
Journal of Herbal Medicine

با ایمپکت فاکتور
2.5

مقالات ما را با هشتگ
#PPIG_PAPER

در کانال تلگرام و صفحه اینستاگرام گروه فیتوفارماکولوژی دنبال کنید.

@ppigpublicity
@usern_net


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272664/

The latest publication by CIP members

Melatonin and cancer suppression: insights into its effects on DNA methylation

Learn more at https://doi.org/10.1186/s11658-022-00375-z

@cip_usern
@usern_net

#PPIG_PAPER

چاپ مقاله گروه فیتوفارماکولوژی با عنوان

Nanoformulations of Plant-Derived Compounds as Emerging Therapeutic Approach for Colorectal Cancer.

در ژورنال

Current Drug Delivery

با ایمپکت فاکتور ۳.۷

مقالات ما را با هشتگ
#PPIG_PAPER

در کانال عمومی تلگرام و صفحه اینستاگرام فیتوفارماکولوژی دنبال کنید.

@ppigpublicity
@usern_net


https://europepmc.org/article/med/36017863

گروه اخترزیست شناسی و زیست فضایی USERN برگزار میکند:

💫دوره آنلاین اخترزیست شناسی مقدماتی💫
مدرس: صالحه عبادی‌راد، کاندیدای دکتری شیمی زمین و محقق اخترزیست‌شناسی از دانشگاه ریورساید کالیفرنیا

📌تعداد جلسات: ۶ جلسه
📌زمان برگزاری: روزهای شنبه و یکشنبه، ساعت ۱۹_۲۰:۳۰

🗓شروع دوره از ۲۰ خردادماه ۱۴۰۲

📧 به همراه ارائه گواهی نامه الکترونیکی
💰قیمت دوره: ۲۵۰ هزار تومان

✨٪۳۰ تخفیف برای ۱۰ نفر اول✨

لینک ثبت نام
@usern_net
@SBART_USERN

▪️دپارتمان اینترست گروپ‌های یوسرن، با نهایت تاسف و تاثر، درگذشت خانم نسرین سیدپور، مدیر اجرایی گروه Nanomedicine Research Association را به خانواده محترم ایشان و جامعه علمی تسلیت می‌گوید.

@usern_IntGrp
@usern_net

Skillverse: Python 💻
"How to Get Started With Python?"
---
📝 Presenter: Saina Adiban
📆 Friday, June 9
🏷 17:00
🪄 Link
---
@sain_usern | @usern_net

✨اولین جلسه گردهمایی اینترست گروپ‌ها و دفاتر داخلی شبکه جهانی آموزش و پژوهش‌های علمی یوسرن با حضور مدیران اجرایی جوان اینترست گروپ‌ها و دفاتر داخلی و تیم اجرایی شاخه اکسترنال یوسرن به صورت هیبرید برگزار شد.

🔹۱۹ مرداد ۱۴۰۲

🔹می‌توانید اخبار اینترست گروپ‌ها و دفاتر یوسرن را از این کانال دنبال کنید:
@usern_external

🔹اطلاعات بیشتر درمورد اینترست گروپ‌ها و دفاتر یوسرن:
https://usern.tums.ac.ir/Group


@usern_net

Glad to share the latest ReMed's research: The food and biomedical applications of curcumin-loaded electrospun nanofibers: A comprehensive review, published in Critical Reviews in Food Science and Nutrition

Many thanks to all the team.

Find the full text from:
https://www.tandfonline.com/doi/abs/10.1080/10408398.2023.2251584

Join the USERN Regenerative Medicine group | @Usern_Remed