Internet of Bodies (IoB)
Using CRISPR to electrically connect with and control the genome

Just like Internet of Things (IoT), IoB refers to access and control of human body via internet. Here, we detail how CRISPR can be used to electrically connect with the genome and as a proof of concept display control over trannoscriptional informational networks inside E. coli and Salmonella.

Technology has played a transformative role in our lives and its impact on human health is never felt more than in the current times of the Covid-19 global pandemic. In this scenario, development of autonomous health sensing and actuating systems, also referred to as closed loop systems that ‘sense’ and ‘act’ towards a biological condition, can play a critical role in addressing health crises of the future. Successful adoption of electronic closed loop human health systems is dependent on the development of new methods for biological actuation which has so far been limited to the century old neural stimulation and optogenetics. Recent advances in the field of biological actuation stems from synthetic biology where our group and others have reported gene circuits that respond to electric signals with expression of specific gene of interests. In a prior publication, our group had detailed a redox-based bacterial promoter SoxS that responds to specific electrochemical signals that can be generated via an external electrode. Using this promoter, specific transgenes of interests can be expressed in bacteria in response to programmed electric stimuli. In this work, we have taken the next logical leap for this technology, that is, using electric signals to connect and control trannoscriptional networks in the genome of the cells. ...

📄https://bioengineeringcommunity.nature.com/posts/using-crispr-to-electrically-connect-with-and-control-the-genome

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BREAKING: Global tech outage hits companies around the world.

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Exposure of human peripheral blood lymphocytes to electromagnetic fields associated with cellular phones leads to chromosomal instability
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📄https://pubmed.ncbi.nlm.nih.gov/12524674/

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Bill Gates and WHO Call For Military To Round Up mRNA Vaccine Refusers During Bird Flu Pandemic - The People's Voice
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📛Bill Gates and WHO Call For Military To Round Up mRNA Vaccine Refusers

PART 2 - PART 1

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