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Pfizer vaccine reprograms innate immune responses


Following vaccination, innate immune cells had a reduced response to.... – all ligands that play an important role in the immune response to viral infection.


In addition, the production of the anti-inflammatory cytokine ... was reduced in response to .... This also suggests a shift towards increased inflammatory responses to fungi following vaccination, say the researchers.


The researchers say that in combination with strong adaptive immune responses, the reprogramming of innate responses could either contribute to a more balanced inflammatory reaction to SARS-CoV-2 infection or a weakened innate immune response.

The effect of the BNT162b2 vaccination on innate immune responses could also interfere with the responses to other vaccinations, adds the team.

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