اولین جلسه مدیران اجرایی و موسسین اینترست گروپ های یوسرن در سال ۲۰۲۲ بصورت هیبرید برگزار شد.
این جلسه به منظور آشنايي گروه ها با يكديگر و معرفي نماينده منتخب گروه ها برگزار شد و در آن راجع به آیین نامه های برگزاری ایونتها و تولید محتوا و همچنین برنامه های آینده صحبت شد و در پایان، گروه ها به ارائه ی نظرات و پیشنهادات خود پرداختند و پيشنهاداتي جهت تشكيل كارگروه هاي مختلف ارائه شد.
📆 ۸ اسفند ماه ۱۴۰۰
📌مرکز طبی کودکان، تهران
به کانال تلگرامی اینترست گروپ های یوسرن بپیوندید:
https://news.1rj.ru/str/usern_IntGrp
@usern_IntGrp
@usern_net
این جلسه به منظور آشنايي گروه ها با يكديگر و معرفي نماينده منتخب گروه ها برگزار شد و در آن راجع به آیین نامه های برگزاری ایونتها و تولید محتوا و همچنین برنامه های آینده صحبت شد و در پایان، گروه ها به ارائه ی نظرات و پیشنهادات خود پرداختند و پيشنهاداتي جهت تشكيل كارگروه هاي مختلف ارائه شد.
📆 ۸ اسفند ماه ۱۴۰۰
📌مرکز طبی کودکان، تهران
به کانال تلگرامی اینترست گروپ های یوسرن بپیوندید:
https://news.1rj.ru/str/usern_IntGrp
@usern_IntGrp
@usern_net
Forwarded from USERN
#FAQ
♨️چگونه میتوانم با یوسرن همکاری پژوهشی داشته باشم؟
همواره یکی از پرتکرارترین سوالات همراهان یوسرن در خصوص چگونگی شروع فعالیت پژوهشی در یوسرن بوده است.
🔹اولین قدم برای شروع کار پژوهشی در USERN ثبت نام در وبسایت یوسرن از طریق این لینک است.
🔹پس از ثبت نام در سایت میتوانید به صفحه اینترست گروپهای یوسرن مراجعه کنید. در این صفحه بیش از ۷۰ گروه فعال وجود دارد. با توجه به فیلد کاری خود و همچنین فیلدی که علاقمند هستید در آن زمینه کار پژوهشی انجام بدهید میتوانید اینترست گروپ مورد نظر را انتخاب کنید.
🔹با کلیک بر روی نام هر گروه وارد صفحه اختصاصی آن گروه شده و میتوانید از آدرس ایمیل و اهداف آن گروه مطلع شوید. بعلاوه میتوانید با کلیک بر روی گزینه activities ، فعالیت های قبلی گروه و کتابها و مقالات چاپ شده را مشاهده کنید.
🔹در نهایت میتوانید با ارسال رزومه خود به آدرس ایمیل گروه مورد نظر درخواست عضویت خود را به مدیریت گروه اعلام نمایید. چنانچه درخواست شما توسط مدیر گروه پذیرفته شود، میتوانید فعالیت پژوهشی خود را آغاز نمایید.
#سوالات_پرتکرار
#پژوهش
#فعالیت_پژوهشی
@usern_net
♨️چگونه میتوانم با یوسرن همکاری پژوهشی داشته باشم؟
همواره یکی از پرتکرارترین سوالات همراهان یوسرن در خصوص چگونگی شروع فعالیت پژوهشی در یوسرن بوده است.
🔹اولین قدم برای شروع کار پژوهشی در USERN ثبت نام در وبسایت یوسرن از طریق این لینک است.
🔹پس از ثبت نام در سایت میتوانید به صفحه اینترست گروپهای یوسرن مراجعه کنید. در این صفحه بیش از ۷۰ گروه فعال وجود دارد. با توجه به فیلد کاری خود و همچنین فیلدی که علاقمند هستید در آن زمینه کار پژوهشی انجام بدهید میتوانید اینترست گروپ مورد نظر را انتخاب کنید.
🔹با کلیک بر روی نام هر گروه وارد صفحه اختصاصی آن گروه شده و میتوانید از آدرس ایمیل و اهداف آن گروه مطلع شوید. بعلاوه میتوانید با کلیک بر روی گزینه activities ، فعالیت های قبلی گروه و کتابها و مقالات چاپ شده را مشاهده کنید.
🔹در نهایت میتوانید با ارسال رزومه خود به آدرس ایمیل گروه مورد نظر درخواست عضویت خود را به مدیریت گروه اعلام نمایید. چنانچه درخواست شما توسط مدیر گروه پذیرفته شود، میتوانید فعالیت پژوهشی خود را آغاز نمایید.
#سوالات_پرتکرار
#پژوهش
#فعالیت_پژوهشی
@usern_net
Forwarded from CIP, Cancer Immunology Project
Exploring the application of immunotherapy against HIV infection in the setting of malignancy: A detailed review article
New paper by CIP Members
🌀ART significantly lowered AIDS-defining malignancies to a nadir, however, Non-AIDS defining cancers are on the rise.
🌀It is hard to make HIV/AIDS vaccines/drugs because of the high mutation rate to a lack of proof-reading functions.
🌀The new ART drugs like Ibalizumab and Pro 140 hold the future landscape of HIV management.
🌀Combinations of ART immunotherapy and cancer immunotherapy drugs offer a glaring promise for treating malignancies in PLWH.
🌀More PLWH with cancers should be included in studies to advance understanding of the effects of new interventions in them.
🌐More at: https://authors.elsevier.com/a/1eWBv5aRFnc0q9
@cip_usern
@usern_IntGrp
@usern_net
New paper by CIP Members
🌀ART significantly lowered AIDS-defining malignancies to a nadir, however, Non-AIDS defining cancers are on the rise.
🌀It is hard to make HIV/AIDS vaccines/drugs because of the high mutation rate to a lack of proof-reading functions.
🌀The new ART drugs like Ibalizumab and Pro 140 hold the future landscape of HIV management.
🌀Combinations of ART immunotherapy and cancer immunotherapy drugs offer a glaring promise for treating malignancies in PLWH.
🌀More PLWH with cancers should be included in studies to advance understanding of the effects of new interventions in them.
🌐More at: https://authors.elsevier.com/a/1eWBv5aRFnc0q9
@cip_usern
@usern_IntGrp
@usern_net
Autoantibodies targeting GPCRs and RAS-related molecules associate with COVID-19 severity
New Paper by USERN Interest Group
🌀COVID-19 shares the feature of autoantibody production with systemic autoimmune diseases.
🌀Here we show, by a cross-sectional study of 246 individuals, that autoantibodies targeting G protein-coupled receptors (GPCR) and RAS-related molecules associate with the clinical severity of COVID-19.
Source: https://doi.org/10.1038/s41467-022-28905-5
@niima_usern
@usern_IntGrp
@usern_net
New Paper by USERN Interest Group
🌀COVID-19 shares the feature of autoantibody production with systemic autoimmune diseases.
🌀Here we show, by a cross-sectional study of 246 individuals, that autoantibodies targeting G protein-coupled receptors (GPCR) and RAS-related molecules associate with the clinical severity of COVID-19.
Source: https://doi.org/10.1038/s41467-022-28905-5
@niima_usern
@usern_IntGrp
@usern_net
Forwarded from USERN
امیدم به بهار است
که این غم برود
و نگاهم به دیار است
که ماتم برود
چه دردی که بر دل گذران است
که سامان نرود
و چه آهی که در دل فوران است
که آسان نرود
مسیرم به رود است
که آبی برود
و صدایم به سرود است
که سبزی برود
که پرواز خیال است
که جایی نرود
و بر این سقف محال است
که بامی نرود
امانم ز بر توست
که با ما برود
و ترسم سفر توست
که تنها برود
به غربت در این خانه فغان است
که از در نرود
وگر رفت به هجران نگران است
که از سر نرود
امیدم به بهار است
که سردی برود
وگر این وهم و غبار است
که عمری برود
نیما رضائی
نوروز ۱۴۰۱
@usern_net
که این غم برود
و نگاهم به دیار است
که ماتم برود
چه دردی که بر دل گذران است
که سامان نرود
و چه آهی که در دل فوران است
که آسان نرود
مسیرم به رود است
که آبی برود
و صدایم به سرود است
که سبزی برود
که پرواز خیال است
که جایی نرود
و بر این سقف محال است
که بامی نرود
امانم ز بر توست
که با ما برود
و ترسم سفر توست
که تنها برود
به غربت در این خانه فغان است
که از در نرود
وگر رفت به هجران نگران است
که از سر نرود
امیدم به بهار است
که سردی برود
وگر این وهم و غبار است
که عمری برود
نیما رضائی
نوروز ۱۴۰۱
@usern_net
Severe COVID-19 Shares a Common Neutrophil Activation Signature with Other Acute Inflammatory States
New Paper by USERN Interest Group
🌀Severe COVID-19 patients present a clinical and laboratory overlap with other hyperinflammatory conditions such as hemophagocytic lymphohistiocytosis (HLH).
🌀These genes are dysregulated at the protein level across several COVID-19 studies and form an interconnected network with differentially expressed plasma proteins that point to neutrophil hyperactivation in COVID-19 patients admitted to the intensive care unit.
🌀scRNAseq analysis indicated that these genes are specifically upregulated across different leukocyte populations, including lymphocyte subsets and immature neutrophils.
Source: https://doi.org/10.3390/cells11050847
@niima_usern
@usern_IntGrp
@usern_net
New Paper by USERN Interest Group
🌀Severe COVID-19 patients present a clinical and laboratory overlap with other hyperinflammatory conditions such as hemophagocytic lymphohistiocytosis (HLH).
🌀These genes are dysregulated at the protein level across several COVID-19 studies and form an interconnected network with differentially expressed plasma proteins that point to neutrophil hyperactivation in COVID-19 patients admitted to the intensive care unit.
🌀scRNAseq analysis indicated that these genes are specifically upregulated across different leukocyte populations, including lymphocyte subsets and immature neutrophils.
Source: https://doi.org/10.3390/cells11050847
@niima_usern
@usern_IntGrp
@usern_net
Role of genetic polymorphisms in recurrent aphthous stomatitis: A systematic review and meta-analysis
New Paper by USERN Interest Group
🌀IL-10, 819 (T allele) and IL-10-1082 (G allele) are associated with increased risk of RAS.
🌀IL-1β+3954 (T allele) and IL-6-174 (G allele) are associated with increased risk of RAS.
🌀IL-1β-511 (C allele) and IL-10-592 (C allele) are associated with decreased risk of RAS.
🌀Cytokines variants are potential predictors of RAS.
🌀Serotonin transporter (L/S) polymorphism is associated with risk of RAS.
Source: https://doi.org/10.1016/j.cyto.2022.155864
@niima_usern
@usern_IntGrp
@usern_net
New Paper by USERN Interest Group
🌀IL-10, 819 (T allele) and IL-10-1082 (G allele) are associated with increased risk of RAS.
🌀IL-1β+3954 (T allele) and IL-6-174 (G allele) are associated with increased risk of RAS.
🌀IL-1β-511 (C allele) and IL-10-592 (C allele) are associated with decreased risk of RAS.
🌀Cytokines variants are potential predictors of RAS.
🌀Serotonin transporter (L/S) polymorphism is associated with risk of RAS.
Source: https://doi.org/10.1016/j.cyto.2022.155864
@niima_usern
@usern_IntGrp
@usern_net
Forwarded from USERN SBMU Office
🌐New Paper by USERN SBMU, FNRC and MAZUMS Offices and NINI Interest Group
📆 March 14, 2022
Title: Delta Variant: The New Challenge of COVID-19 Pandemic, an Overview of Epidemiological, Clinical, and Immune Characteristics
Journal: Acta Biomedica Atenei Parmensis
Source: https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/12210/10586
@sbmusern
@fnrcusern
@Usern_mazums
@nini_usern
@usern_net
📆 March 14, 2022
Title: Delta Variant: The New Challenge of COVID-19 Pandemic, an Overview of Epidemiological, Clinical, and Immune Characteristics
Journal: Acta Biomedica Atenei Parmensis
Source: https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/12210/10586
@sbmusern
@fnrcusern
@Usern_mazums
@nini_usern
@usern_net
Central Inflammatory Cytokines in Tuberculous Meningitis: A Systematic Review and Meta-analysis
New Paper by USERN Interest Groups
🌀No formal agreement exists regarding central inflammatory cytokine aberrations in tuberculosis (TB). We undertook a systematic review and meta-analysis of studies comparing cytokine levels in cerebrospinal fluid (CSF) from patients with TB compared with controls.
🌀This study should be considered an explorative meta-analytic review, leading us to offer the best TBM-associated central inflammatory cytokines. Our study could prepare a panel of central cytokines as a potential aid in diagnosing TBM and its differentiation from meningitis of other etiologies.
Source: https://doi.org/10.1089/jir.2021.0176
@niima_usern
@srmeg_usern
@usern_IntGrp
@usern_net
New Paper by USERN Interest Groups
🌀No formal agreement exists regarding central inflammatory cytokine aberrations in tuberculosis (TB). We undertook a systematic review and meta-analysis of studies comparing cytokine levels in cerebrospinal fluid (CSF) from patients with TB compared with controls.
🌀This study should be considered an explorative meta-analytic review, leading us to offer the best TBM-associated central inflammatory cytokines. Our study could prepare a panel of central cytokines as a potential aid in diagnosing TBM and its differentiation from meningitis of other etiologies.
Source: https://doi.org/10.1089/jir.2021.0176
@niima_usern
@srmeg_usern
@usern_IntGrp
@usern_net
Quercetin potential effects against SARS-CoV-2 infection and COVID-19-associated cancer progression by inhibiting mTOR and hypoxia-inducible factor-1α (HIF-1α)
New Paper by USERN Interest Group
🌀Globally, the coronavirus disease-2019 (COVID-19) pandemic has spread rapidly, with millions of confirmed cases.
🌀Based on the studies, it seems that cancer patients not only are more prone to experience severe complications and death by COVID-19, but also cancer progression by COVID-19.
🌀We hypothesize that quercetin, as a safe flavonoid that exists in various fruits and vegetables, not only can be used as an anti-COVID-19 component with potential effects on interfacing the viral entry, replication, and its inflammatory activity but also can disrupt the signaling pathways stimulated and upregulated factors by SARS-CoV-2 infection (e.g., mTOR, HIF-1α, etc.), which may lead to cancer progression.
Source: https://doi.org/10.1002/ptr.7440
@niima_usern
@usern_IntGrp
@usern_net
New Paper by USERN Interest Group
🌀Globally, the coronavirus disease-2019 (COVID-19) pandemic has spread rapidly, with millions of confirmed cases.
🌀Based on the studies, it seems that cancer patients not only are more prone to experience severe complications and death by COVID-19, but also cancer progression by COVID-19.
🌀We hypothesize that quercetin, as a safe flavonoid that exists in various fruits and vegetables, not only can be used as an anti-COVID-19 component with potential effects on interfacing the viral entry, replication, and its inflammatory activity but also can disrupt the signaling pathways stimulated and upregulated factors by SARS-CoV-2 infection (e.g., mTOR, HIF-1α, etc.), which may lead to cancer progression.
Source: https://doi.org/10.1002/ptr.7440
@niima_usern
@usern_IntGrp
@usern_net
Neurological and neuropsychological adverse effects of SARS-CoV-2 vaccines – where do we stand?
New Paper by USERN Interest Group
🌀We discuss different neurological and neuropsychological adverse effects of COVID-19 vaccines including demyelinating diseases, Bell’s palsy (BP), cerebrovascular complications, seizures, functional neurological disorders (FNDs), and some other rare adverse events, and hypothetical mechanisms which can lead to the reported side effects.
🌀Given the fact that the incidence of such events are rare and most of them are treatable, the current review aims to shed light on how much the relationship between COVID-19 vaccines and these complications can be reliable.
Source: https://doi.org/10.1515/revneuro-2022-0006
@niima_usern
@usern_IntGrp
@usern_net
New Paper by USERN Interest Group
🌀We discuss different neurological and neuropsychological adverse effects of COVID-19 vaccines including demyelinating diseases, Bell’s palsy (BP), cerebrovascular complications, seizures, functional neurological disorders (FNDs), and some other rare adverse events, and hypothetical mechanisms which can lead to the reported side effects.
🌀Given the fact that the incidence of such events are rare and most of them are treatable, the current review aims to shed light on how much the relationship between COVID-19 vaccines and these complications can be reliable.
Source: https://doi.org/10.1515/revneuro-2022-0006
@niima_usern
@usern_IntGrp
@usern_net
Hyper IgE syndromes: A clinical approach
New Paper by USERN Interest Group
🌀There are several distinct immunodeficiency disorders which are phenotypically similar to HIES.
🌀The diagnosis of HIES is typically based on the clinical suspicion and immunological assessments.
🌀The genetic diagnosis is important for the therapeutic approaches.
Source: https://doi.org/10.1016/j.clim.2022.108988
@niima_usern
@usern_IntGrp
@usern_net
New Paper by USERN Interest Group
🌀There are several distinct immunodeficiency disorders which are phenotypically similar to HIES.
🌀The diagnosis of HIES is typically based on the clinical suspicion and immunological assessments.
🌀The genetic diagnosis is important for the therapeutic approaches.
Source: https://doi.org/10.1016/j.clim.2022.108988
@niima_usern
@usern_IntGrp
@usern_net
Acute disseminated encephalomyelitis (ADEM) after SARS- CoV-2 vaccination: A case report
New Paper by USERN Interest Group
🌀Here, we present a 37 y/o male patient with progressive muscle weakness in all limbs along with dysphagia following COVID-19 vaccination.
🌀Brain magnetic resonance imaging (MRI) revealed typical imaging findings which presented as multifocal T2-FLAIR signal changes in the corticospinal tract, pons, and temporal lobe with diffusion restriction.
🌀Magnetic resonance spectroscopy (MRS) further confirmed the diagnosis by the typical elevation of the Choline and Myoinositol peaks.
Source: https://doi.org/10.1016/j.radcr.2022.03.013
@niima_usern
@usern_IntGrp
@usern_net
New Paper by USERN Interest Group
🌀Here, we present a 37 y/o male patient with progressive muscle weakness in all limbs along with dysphagia following COVID-19 vaccination.
🌀Brain magnetic resonance imaging (MRI) revealed typical imaging findings which presented as multifocal T2-FLAIR signal changes in the corticospinal tract, pons, and temporal lobe with diffusion restriction.
🌀Magnetic resonance spectroscopy (MRS) further confirmed the diagnosis by the typical elevation of the Choline and Myoinositol peaks.
Source: https://doi.org/10.1016/j.radcr.2022.03.013
@niima_usern
@usern_IntGrp
@usern_net
Cytokine-induced killer cells mediated pathways in the treatment of colorectal cancer
New Paper by USERN Interest Group
🌀Cytokine-induced killer (CIK) cell therapy is a type of adoptive immunotherapy that due to its high proliferation rate and anti-tumor characteristics, is being investigated to treat various solid tumors.
🌀This review aims to summarize the clinical studies that investigated the safety and clinical efficacy of CIK cell therapy in CRC.
Source: https://doi.org/10.1186/s12964-022-00836-0
@niima_usern
@usern_IntGrp
@usern_net
New Paper by USERN Interest Group
🌀Cytokine-induced killer (CIK) cell therapy is a type of adoptive immunotherapy that due to its high proliferation rate and anti-tumor characteristics, is being investigated to treat various solid tumors.
🌀This review aims to summarize the clinical studies that investigated the safety and clinical efficacy of CIK cell therapy in CRC.
Source: https://doi.org/10.1186/s12964-022-00836-0
@niima_usern
@usern_IntGrp
@usern_net
Forwarded from Alzheimer’s Disease Institute
The latest publication by the NRG interest group
Autoimmune encephalitis after COVID-19 infection
https://www.msard-journal.com/article/S2211-0348(22)00302-9/fulltext
@nrg_usern
Autoimmune encephalitis after COVID-19 infection
https://www.msard-journal.com/article/S2211-0348(22)00302-9/fulltext
@nrg_usern
📕Encyclopedia of Infection and Immunity
Reference Work • 2022
New Book by USERN Interest Group
📗Editor-in-Chief: Nima Rezaei
🔹Department of Immunology, School of Medicine, Tehran University of Medical Sciences,
🔹Research Center for Immunodeficiencies, Children's Medical Center,
🔹Universal Scientific Education and Research Network (USERN)
📘Four Volume Set provides new insights into the interactions between bacteria, fungi, parasites and their host innate and adaptive immune response.
📙Comprised of over 200 chapters (3200 pages) written and edited by leading experts in the field, this book will serve as a key resource for students, researchers, academics and industry practitioners in the fields of microbiology, immunology, and infectious diseases.
https://www.sciencedirect.com/referencework/9780323903035/encyclopedia-of-infection-and-immunity
@niima_usern
@usern_net
Reference Work • 2022
New Book by USERN Interest Group
📗Editor-in-Chief: Nima Rezaei
🔹Department of Immunology, School of Medicine, Tehran University of Medical Sciences,
🔹Research Center for Immunodeficiencies, Children's Medical Center,
🔹Universal Scientific Education and Research Network (USERN)
📘Four Volume Set provides new insights into the interactions between bacteria, fungi, parasites and their host innate and adaptive immune response.
📙Comprised of over 200 chapters (3200 pages) written and edited by leading experts in the field, this book will serve as a key resource for students, researchers, academics and industry practitioners in the fields of microbiology, immunology, and infectious diseases.
https://www.sciencedirect.com/referencework/9780323903035/encyclopedia-of-infection-and-immunity
@niima_usern
@usern_net
Forwarded from Alzheimer’s Disease Institute
♦️The latest publication by NRG♦️
Pseudobulbar affect is a missed diagnosed complication that can be observed in neurodegenerative diseases. In this study, we evaluate the prevalence of PBA in Alzheimer’s disease, Parkinson’s disease, Multiple sclerosis and amyotrophic lateral sclerosis.
https://www.sciencedirect.com/science/article/abs/pii/S0967586822001679
@NRG_USERN
Pseudobulbar affect is a missed diagnosed complication that can be observed in neurodegenerative diseases. In this study, we evaluate the prevalence of PBA in Alzheimer’s disease, Parkinson’s disease, Multiple sclerosis and amyotrophic lateral sclerosis.
https://www.sciencedirect.com/science/article/abs/pii/S0967586822001679
@NRG_USERN
Role of serology tests in COVID-19 non-hospitalized patients: A cross-sectional study
New Paper by USERN Interest Group
🌀We have surveyed 1,363 outpatients with suspected COVID-19 in Tehran, Iran. The analysis emphasized on characteristics of patients with positive PCR or serology of SARS-CoV-2.
🌀Conclusion: Assessing antibody titers in outpatients is invaluable due to the epidemiological importance of investigations in mild or even asymptomatic cases. Since the number of such studies in non-hospitalized patients is not high, the current study can be used as a comparison model.
Source: https://doi.org/10.1371/journal.pone.0266923
@niima_usern
New Paper by USERN Interest Group
🌀We have surveyed 1,363 outpatients with suspected COVID-19 in Tehran, Iran. The analysis emphasized on characteristics of patients with positive PCR or serology of SARS-CoV-2.
🌀Conclusion: Assessing antibody titers in outpatients is invaluable due to the epidemiological importance of investigations in mild or even asymptomatic cases. Since the number of such studies in non-hospitalized patients is not high, the current study can be used as a comparison model.
Source: https://doi.org/10.1371/journal.pone.0266923
@niima_usern