RKI releases table concerning qPCR Omicron Readout Errors

RKI Source PCR gene List (Download XLSX)

Omicron variant BA.2 a.k.a "Stealth Omicron", underscores the qPCR-readout errors and possible "protein mutations cross-confirmations". The RKI-URL including the gene list is naturally cloaked in some sugar-coating:

As more omicron sequences become available, this overview will continue to improve. (in other words: "Nooooo Muuuh Nooooo!")

Here is a list of genes-sources for possible picked up "protein-mutations" by qPCR, it was collected by a fellow Anon fren:

K417N: Yeast

N440K: N440K sodium channel mutation causes myotonia

G446S: Congenital adrenal hyperplasia due to 11β-hydroxylase deficiency / TUR8A G446S/G446S 46,XX F Caucasian/Turkish 4.9 2

A67V: Mutations in uterine leiomyosarcoma and colorectal cancer

G339D: Glycogen storage disease type Ib (GSD-Ib)

S371: Monoclonal Antibodies VS Influenza

S373P: rfa1-t33 substitution

Nextclade List (Hi Res) is without "BA.3"

@bobbynetwork

In Silico SARS-CoV-2 Epitopes Inhibit-possibilities

"Identifcation of potential edible mushroom as SARS‑CoV‑2 main protease inhibitor using rational drug designing approach

[.] we have identified promising hits against the main protease (Mpro) of SARS-CoV-2 from edible mushrooms. Structure-based virtual screening (VS) of 2433 compounds derived from mushrooms was performed with Mpro protein (6LU7). Four promising hits, [.], Kynapcin-12 (M_78), Kynapcin-28 (M_82), Kynapcin-24 (M_83), and Neonambiterphenyls-A (M_366) were identifed [.]

The promising hits Kynapcin-12 (M_78), Kynapcin-28 (M_82), Kynapcin-24 (M_83) are available in edible mushroom Polyozellus multiplex and another promising hit Neonambiterphenyls-A (M_366) is available in the poisonous mushroom Neonothopanus nimbi.

[.] scores greater than co-ligand and comparable docking scores with the two known SARS-CoV-2 inhibitors."

Received: 30.7.2021
Accepted: 03.1.2022

Nature
1, 2, 3
Tweet

Yes, Kynapcin could be in Cubensis.

@bobbynetwork

Comments Group has been temporarily disabled. Edit: It has been deleted now. It will for sure return sometime in the future, so stay tuned. A bit of cleaning was needed.

[06.02.22 14:48]
[Forwarded from Stephanie]

Aseem Malhotra is actually a Friend of mine and working as a preventative cardiologist. He is not sponsored by pharma and is trying to expose it..and not from now, from long ago. He has tried to get involved in changing government policies on health, but unfortunately they did not listen to him. He gave up "normal" healthcare and is trying to help ppl heal through nutrition and others..but hey..

I was looking actually for his thesis... but only found some "2030" forecasting and 75 seems to appear quite often in his twitter timeline (all archived already).

https://twitter.com/DrAseemMalhotra/status/370139810486554624

https://archive.is/wip/z2BB9

Omicron Envelope Mutation T9I

Background:

Some weeks ago I was looking for possible explanations why the unusual Envelope Mutation T9I was persistently carried along the B-variants phylogenetic tree-timeline.

Turns out that this odd mutation is also responsible for mild disease progression in Omicron variants:

Why SARS-CoV-2 Omicron variant is milder? A single high-frequency mutation of structural envelope protein matters

"This new study suggests that a single mutation (T9I) in the envelope protein of Omicron may be at least partially responsible for it's comparably mild disease progression"

[thx to @drallcome for pointing this out]

This indicates even more Omicron's lab origin. The Envelope Protein is one of the most conserved regions within the hCoV genome: T9I either appeared thousands of years ago - if not millions - in a wildtype-setting, or it was inserted into a new kind of backbone that is not registered / spotted up2date .

@bobbynetwork