Topic: "Unexpected Cell Signals via Spike"

"[.] Spike Protein Elicits Cell Signaling in Human Host Cells: Implications for Possible Consequences of COVID-19 Vaccines

[.] consider their long-term consequences carefully, [.] when they are administered to [.] healthy individuals [.]."

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7827936/

"IL-6 Signalling? Nooooo! Muuuuuh!" (Yes)

Flashback Dec 2020:
"[.] spike protein promotes IL-6 trans-signaling by activation of ACE2 receptor signaling in epithelial cells"

https://pubmed.ncbi.nlm.nih.gov/33284859/

"Muuuh IL-6 Signal does nothing Muuuh" (It does)

Flashback 2012: "IL-6 Trans-Signaling via the Soluble IL-6 Receptor: Importance for the Pro-Inflammatory Activities of IL-6"

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3491447/

More Spike/Cell-Signalling:

"SARS-CoV-2 Spike Protein Induces Paracrine Senescence and Leukocyte Adhesion in Endothelial Cells"

https://journals.asm.org/doi/10.1128/JVI.00794-21

Thread:

https://bit.ly/3HxVNxB

"Muuuuuuh Stop it Bobby Stop it Muuuuuuuuuuh!" (No)

Have a meme to cheer you up, let's return to happier topics, how about Bio Distribution of LNPs?

LNP 101:

https://www.cas.org/resource/blog/understanding-nanotechnology-covid-19-vaccines

⤍LNP could have targeted ligands (outside), would only transfect muscle cells

⤍Big Pharma designed with PEG polymers (outside) to evade immune system

⤍"PEG reason for LNP throughout body, no targeting ligands ⤍ transfect any cell"

Connected:

https://twitter.com/Bobby_Network/status/1457092712881131527

https://www.pmda.go.jp/drugs/2021/P20210212001/672212000_30300AMX00231_I100_1.pdf

Ongoing mRNA-Spike-Only-Focus-Shit-Show-Collection:

https://threadreaderapp.com/thread/1447787430233481218?refresh=1637276682

"Muuuh Stop it, no more LNP-talk, return to Mutational Dynamics of S1 & Evasion" (OK)

"SARS-CoV-2 immune evasion by B.1.427/B.1.429 variant of concern

B.1.427/B.1.429 S variant [.] unusual neutralization escape strategy."

https://www.science.org/doi/full/10.1126/science.abi7994#F4

Connected:

https://twitter.com/Bobby_Network/status/1447799414119088132

https://www.biorxiv.org/content/10.1101/2021.09.11.459844v1

Ongoing mRNA-Spike-Only-Focus-Shit-Show-Collection:

https://threadreaderapp.com/thread/1447787430233481218?refresh=1637276682

"Rates of SARS-CoV-2 transmission & vaccination impact the fate of vaccine-resistant strains

[.] 3 risk factors favour vaccine-resistant strain:

⤑high probability of initial emergence of resistant strain,

⤑high Nr. infected,

⤑low % vaccination."

In other words: unless vaccination is done quickly, there will be a high probability of escape mutants.

https://www.nature.com/articles/s41598-021-95025-3

As this shows: The United Booster Empire will need a lot of micro-management-autism and everything will be tightly scheduled to obtain VIP-status, it's literally a race with time and every day counts. Non-sterilizing mRNA Transfection is no Walk In The Park. It might get interrupted by the "Original Antigenic Sin" and "Immune Imprinting" additionally.

Weekly / Daily Boosters? "Don't talk to me unless you are GigaVaxxed".

Ongoing mRNA-Spike-Only-Focus-ShitShow-Fest-Collection:

https://threadreaderapp.com/thread/1447787430233481218?refresh=1637276682

"Muuuh Stop the Mutational Dynamics Bobby, stop it now!" (Ok, how about ADE?).

Flashback 2005: "Caution raised over SARS vaccine

[.] a jab against one strain might even aggravate an infection with SARS virus from civets or another species."

https://www.nature.com/articles/news050110-3#ref-CR1

FastForward July 2020:

"A perspective on potential antibody-dependent enhancement of SARS-CoV-2

hypothesis that ADE is a consequence of low-affinity antibodies that bind to viral entry proteins but have limited or no neutralizing activity."

https://www.nature.com/articles/s41586-020-2538-8

FastForward September 2020:

"Antibody-dependent enhancement of coronavirus

[.] a potential risk in the vaccine therapy for the novel coronavirus SARS-CoV-2, as it shares the same viral receptor and similar genome sequence with SARS-CoV."

https://pubmed.ncbi.nlm.nih.gov/32920233/

Ongoing mRNA-Spike-Only-Shit-Show-Fest-Collection:

https://threadreaderapp.com/thread/1447787430233481218?refresh=1635109424

ADE - FastForward Feb2021:

"At the Intersection: SARS-CoV-2 / Macrophages & the Adaptive Immune Response: A Key Role for Antibody Dependent Pathogenesis But Not Enhancement of Infection in COVID-19"

https://www.researchgate.net/publication/349568846_At_the_Intersection_Between_SARS-CoV-2_Macrophages_and_the_Adaptive_Immune_Response_A_Key_Role_for_Antibody-Dependent_Pathogenesis_But_Not_Enhancement_of_Infection_in_COVID-19

Connected:

https://twitter.com/Bobby_Network/status/1457050163948802048

mRNA-Spike-Only-Shit-Show-Fest-Collection:

https://threadreaderapp.com/thread/1447787430233481218?refresh=1635109424