"Differences in Vaccine and SARS-CoV-2 Replication Derived mRNA: Implications for Cell Biology and Future Disease

Kevin McKernan, Anthony M. Kyriakopoulos, Peter McCullough

Codon optimization describes the process used to increase protein production by use of alternative but synonymous codon changes. In SARS-CoV-2 mRNA vaccines codon optimizations can result in differential secondary conformations that inevitably affect a protein’s function with significant consequences to the cell. Importantly, when codon optimization increases the GC content of synthetic mRNAs, there can be an inevitable enrichment of G-quartets which potentially form G-quadruplex structures. The emerging G-quadruplexes are favorable binding sites of RNA binding proteins like helicases that inevitably affect epigenetic reprogramming of the cell by altering trannoscription, translation and replication. In this study, we performed a RNA fold analysis to investigate alterations in secondary structures of mRNAs inSARS-CoV-2 vaccines due to codon optimization. We show a significant increase in the GC content of mRNAs in vaccines as compared to native SARS-CoV-2 RNA sequences encoding the spike protein. As the GC enrichment leads to more G-quadruplex structure formations, these may contribute to potential pathological processes initiated by SARS-CoV-2 molecular vaccination."

https://osf.io/bcsa6/

https://anandamide.substack.com/p/differences-in-vaccine-and-sars-cov

"Yay Lockdown for the lower caste on the Titanic"

feat. the Austrian Ministry of "Health" ("Security"), the unelected Prime Minister and our senile president + many more.

Date: 24th Nov 2021,
General Lockdown Start: 22nd Nov

Connected:
https://news.1rj.ru/str/bobbynetwork/758

Minister of "Labour" Martin Kocher taking a close-up of Karin Edtstadler's arse (Minister for EU & "Constitution" [sic!], Chancellery Austria).

Same party, same date, 2 days after General Lockdown Start.

[thx 2 https://news.1rj.ru/str/stefankriz for pointing out]

The Memes film themselves.

Connected:
https://news.1rj.ru/str/bobbynetwork/757

Omicron Spike in complex human ACE2:

⇢ This doesn't reveal anything regarding virulence (yet)
⇢ Green ribbon = ACE2, below = RBD (S1 sub unit)
⇢ RBD shows documented phenotypic aminoacid changes (orange dots), cyan = deletions, green = undocumented

(GISAID screen capture)