By reconstructing extinct enzymes from millions of years ago, researchers show that cannabis evolved the ability to produce THC, CBD and CBC through gene duplication and enzyme specialization, identifying ancestral enzymes with potential for biotechnological and medicinal cannabinoid production.
https://onlinelibrary.wiley.com/doi/10.1111/pbi.70475
https://redd.it/1q26npc
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https://onlinelibrary.wiley.com/doi/10.1111/pbi.70475
https://redd.it/1q26npc
@r_sciencegeeks
Wiley Online Library
Resurrected Ancestral Cannabis Enzymes Unveil the Origin and Functional Evolution of Cannabinoid Synthases
Cannabinoids, such as tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA) and cannabichromenic acid (CBCA), are bioactive and medicinally relevant compounds found in the cannabis plant (Can...
Loneliness and self-doubt mediate the link between depression and meaning in life. The research identifies specific psychological pathways that vary across different developmental stages, from adolescence to middle adulthood.
https://www.psypost.org/loneliness-and-self-doubt-mediate-the-link-between-depression-and-meaning-in-life/
https://redd.it/1q27kuv
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https://www.psypost.org/loneliness-and-self-doubt-mediate-the-link-between-depression-and-meaning-in-life/
https://redd.it/1q27kuv
@r_sciencegeeks
PsyPost
Loneliness and self-doubt mediate the link between depression and meaning in life
Why does life feel less meaningful when you are depressed? New research suggests loneliness and poor self-evaluation are the culprits, but the mechanism shifts depending on whether you are a teen or an adult.
Masculinity, emotional regulation, and alcohol use after romantic conflict shows that individuals with stronger masculine orientations are more likely to drink after relationship disagreements, driven primarily by negative emotions such as anger and jealousy rather than biological sex.
https://journals.sagepub.com/doi/10.1177/02654075251389249
https://redd.it/1q2c36z
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https://journals.sagepub.com/doi/10.1177/02654075251389249
https://redd.it/1q2c36z
@r_sciencegeeks
Sage Journals
Masculine and feminine orientations on emotions and alcohol use in response to romantic conflict - Lindsey M. Rodriguez, Jennifer…
This research examines associations of gender role (i.e., masculine and feminine) orientations with drinking alcohol shortly after a recent significant romantic...
Circadian rhythm, the body’s internal clock, may affect a person’s risk of dementia. People with weaker or more irregular body clocks had a higher risk of developing dementia. Being most active later in the day, instead of earlier, was linked to a 45% increased risk of dementia.
https://www.aan.com/PressRoom/Home/PressRelease/5306
https://redd.it/1q2cw7y
@r_sciencegeeks
https://www.aan.com/PressRoom/Home/PressRelease/5306
https://redd.it/1q2cw7y
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Reddit
From the science community on Reddit: Circadian rhythm, the body’s internal clock, may affect a person’s risk of dementia. People…
Posted by mvea - 110 votes and 9 comments
Breast cancer hijacks the immune system’s alarm by rewiring the cGAS-STING pathway, transforming anti-tumor defense into chronic inflammation that fuels tumor growth, suppresses immunity, increases PD-L1 expression, and reveals a clear, targetable vulnerability to immunotherapy.
https://www.sciencedirect.com/science/article/abs/pii/S2095927325012630?via%3Dihub
https://redd.it/1q2e97f
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https://www.sciencedirect.com/science/article/abs/pii/S2095927325012630?via%3Dihub
https://redd.it/1q2e97f
@r_sciencegeeks
Reddit
From the science community on Reddit: Breast cancer hijacks the immune system’s alarm by rewiring the cGAS-STING pathway, transforming…
Posted by Sciantifa - 41 votes and 2 comments
Candidozyma auris (formerly Candida auris): Resistant, long-lasting, and everywhere
https://www.clinicalmicrobiologyandinfection.org/article/S1198-743X(25)00633-0/fulltext
https://redd.it/1q2g77q
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https://www.clinicalmicrobiologyandinfection.org/article/S1198-743X(25)00633-0/fulltext
https://redd.it/1q2g77q
@r_sciencegeeks
Clinical Microbiology and Infection
Candidozyma auris (formerly Candida auris): Resistant, long-lasting, and everywhere
Invasive fungal diseases are a growing global health concern, with Candidozyma auris
(formerly Candida auris) emerging as a major healthcare-associated pathogen. Its multidrug
resistance, environmental persistence, prolonged skin colonization, and efficient…
(formerly Candida auris) emerging as a major healthcare-associated pathogen. Its multidrug
resistance, environmental persistence, prolonged skin colonization, and efficient…
Studies show that scratching overrides itch signals and engages pain-modulating regions in the brain, creating a sense of relief and calm
https://www.ndtv.com/lifestyle/people-are-now-making-rs-9-000-an-hour-by-scratching-someones-back-literally-10201508
https://redd.it/1q2mg2e
@r_sciencegeeks
https://www.ndtv.com/lifestyle/people-are-now-making-rs-9-000-an-hour-by-scratching-someones-back-literally-10201508
https://redd.it/1q2mg2e
@r_sciencegeeks
www.ndtv.com
People Are Now Making Rs 9,000 An Hour By Scratching Someone's Back, Literally
Studies show that scratching overrides itch signals and engages pain-modulating regions in the brain, creating a sense of relief and calm
Ammonite survival across the Cretaceous–Paleogene boundary confirmed by new data from Denmark
https://www.nature.com/articles/s41598-025-34479-1?fbclid=IwVERDUAPD2H1leHRuA2FlbQIxMABzcnRjBmFwcF9pZAwzNTA2ODU1MzE3MjgAAR5dgcEtDf8XV9FnmYcgAJ9d3ekegUaR97_RGJlC27axaiHExdoU2vOwTE75Gg_aem_aj75S2KHVX09uErPQhryAQ
https://redd.it/1q2ld9w
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https://www.nature.com/articles/s41598-025-34479-1?fbclid=IwVERDUAPD2H1leHRuA2FlbQIxMABzcnRjBmFwcF9pZAwzNTA2ODU1MzE3MjgAAR5dgcEtDf8XV9FnmYcgAJ9d3ekegUaR97_RGJlC27axaiHExdoU2vOwTE75Gg_aem_aj75S2KHVX09uErPQhryAQ
https://redd.it/1q2ld9w
@r_sciencegeeks
Nature
Ammonite survival across the Cretaceous–Paleogene boundary confirmed by new data from Denmark
Scientific Reports - Ammonite survival across the Cretaceous–Paleogene boundary confirmed by new data from Denmark
Injectable nanoparticles reprogram immune cells within tumors to attack cancer: New therapy directly converts macrophages inside tumors into anti-cancer cell therapies. In mouse models with melanoma, tumor growth was markedly suppressed, and therapeutic effect extended to a systemic immune response.
https://www.dongascience.com/en/news/75756
https://redd.it/1q2s0dh
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https://www.dongascience.com/en/news/75756
https://redd.it/1q2s0dh
@r_sciencegeeks
Dongascience
Injectable Nanoparticles Reprogram Immune Cells Within Tumors to Attack Cancer
Tumors contain macrophages, immune cells capable of fighting cancer, but their function is suppressed by the tumor, preventing them from performing their role. South Korean researchers have developed
Individuals with high levels of psychopathic traits had a 9.3 times higher risk of developing schizophrenia compared to individuals with low levels of these traits. Individuals classified as psychopathic were 2.37 times more likely to develop schizophrenia compared to their non-psychopathic peers.
https://www.psypost.org/psychopathic-traits-are-associated-with-a-substantially-increased-risk-of-schizophrenia/
https://redd.it/1q2sywu
@r_sciencegeeks
https://www.psypost.org/psychopathic-traits-are-associated-with-a-substantially-increased-risk-of-schizophrenia/
https://redd.it/1q2sywu
@r_sciencegeeks
PsyPost
Psychopathic traits are associated with a substantially increased risk of schizophrenia
Individuals with high levels of psychopathy are over nine times more likely to develop schizophrenia than those with low levels, according to a 40-year longitudinal study of forensic psychiatric patients in Finland.
Why Some Bacteria Survive Antibiotics and How to Stop Them - New study reveals that bacteria can survive antibiotic treatment through two fundamentally different “shutdown modes”
https://www.eurekalert.org/news-releases/1111357
https://redd.it/1q2t5lj
@r_sciencegeeks
https://www.eurekalert.org/news-releases/1111357
https://redd.it/1q2t5lj
@r_sciencegeeks
EurekAlert!
Why Some Bacteria Survive Antibiotics and How to Stop Them - New study reveals that bacteria can survive antibiotic treatment through…
New study reveals that bacteria can survive antibiotic treatment through two fundamentally different “shutdown modes,” not just the classic idea of dormancy. The researchers show that some cells enter a regulated, protective growth arrest, a controlled…
Research shows that a single binge-drinking episode—about four drinks for women or five for men in two hours—can weaken the gut in measurable ways. Even in healthy adults, alcohol makes the intestinal lining more permeable, allowing bacteria and toxins to enter the bloodstream.
https://onlinelibrary.wiley.com/doi/10.1111/acer.70196
https://redd.it/1q2ugt0
@r_sciencegeeks
https://onlinelibrary.wiley.com/doi/10.1111/acer.70196
https://redd.it/1q2ugt0
@r_sciencegeeks
Wiley Online Library
Unraveling the gastrointestinal tract's response to alcohol binges: Neutrophil recruitment, neutrophil extracellular traps, and…
This study demonstrates that binge drinking induces proximal small intestine (PSI) injury resulting in villous blunting, neutrophil infiltration, and neutrophil extracellular trap (NET) formation, wh...
Research shows that a single binge-drinking episode—about four drinks for women or five for men in two hours—can weaken the gut in measurable ways. Even in healthy adults, alcohol makes the intestinal lining more permeable, allowing bacteria and toxins to enter the bloodstream.
https://onlinelibrary.wiley.com/doi/10.1111/acer.70196
https://redd.it/1q2ugt0
@r_sciencegeeks
https://onlinelibrary.wiley.com/doi/10.1111/acer.70196
https://redd.it/1q2ugt0
@r_sciencegeeks
Wiley Online Library
Unraveling the gastrointestinal tract's response to alcohol binges: Neutrophil recruitment, neutrophil extracellular traps, and…
This study demonstrates that binge drinking induces proximal small intestine (PSI) injury resulting in villous blunting, neutrophil infiltration, and neutrophil extracellular trap (NET) formation, wh...
Circadian rhythm, the body’s internal clock, may affect a person’s risk of dementia. People with weaker or more irregular body clocks had a higher risk of developing dementia. Being most active later in the day, instead of earlier, was linked to a 45% increased risk of dementia.
https://www.aan.com/PressRoom/Home/PressRelease/5306
https://redd.it/1q2cw7y
@r_sciencegeeks
https://www.aan.com/PressRoom/Home/PressRelease/5306
https://redd.it/1q2cw7y
@r_sciencegeeks
Reddit
From the science community on Reddit: Circadian rhythm, the body’s internal clock, may affect a person’s risk of dementia. People…
Posted by mvea - 110 votes and 9 comments
A woman’s knowledge of her own anatomy and feelings toward her genitals are strong predictors of her solitary sexual behaviors. Study also suggests that women who engage in self-stimulation during adolescence may experience orgasms more frequently with partners later in life.
https://www.psypost.org/new-study-explores-factors-linked-to-womens-masturbation-habits/
https://redd.it/1q2z3ie
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https://www.psypost.org/new-study-explores-factors-linked-to-womens-masturbation-habits/
https://redd.it/1q2z3ie
@r_sciencegeeks
PsyPost
New study explores factors linked to women’s masturbation habits
How much women know about their anatomy impacts their solitary sexual behavior.
Individuals with high levels of psychopathic traits had a 9.3 times higher risk of developing schizophrenia compared to individuals with low levels of these traits. Individuals classified as psychopathic were 2.37 times more likely to develop schizophrenia compared to their non-psychopathic peers.
https://www.psypost.org/psychopathic-traits-are-associated-with-a-substantially-increased-risk-of-schizophrenia/
https://redd.it/1q2sywu
@r_sciencegeeks
https://www.psypost.org/psychopathic-traits-are-associated-with-a-substantially-increased-risk-of-schizophrenia/
https://redd.it/1q2sywu
@r_sciencegeeks
PsyPost
Psychopathic traits are associated with a substantially increased risk of schizophrenia
Individuals with high levels of psychopathy are over nine times more likely to develop schizophrenia than those with low levels, according to a 40-year longitudinal study of forensic psychiatric patients in Finland.
Rising food prices linked to increased childhood obesity and chronic malnutrition, due to families prioritizing cheaper calories over nutrient-rich foods. This also results in a 'hidden deficiency' of important micronutrients, which slows down height growth without reducing body weight
https://www.uni-bonn.de/en/news/001-2026
https://redd.it/1q2z6fh
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https://www.uni-bonn.de/en/news/001-2026
https://redd.it/1q2z6fh
@r_sciencegeeks
Universität Bonn
Expensive food makes children fat
Why Some Bacteria Survive Antibiotics and How to Stop Them - New study reveals that bacteria can survive antibiotic treatment through two fundamentally different “shutdown modes”
https://www.eurekalert.org/news-releases/1111357
https://redd.it/1q2t5lj
@r_sciencegeeks
https://www.eurekalert.org/news-releases/1111357
https://redd.it/1q2t5lj
@r_sciencegeeks
EurekAlert!
Why Some Bacteria Survive Antibiotics and How to Stop Them - New study reveals that bacteria can survive antibiotic treatment through…
New study reveals that bacteria can survive antibiotic treatment through two fundamentally different “shutdown modes,” not just the classic idea of dormancy. The researchers show that some cells enter a regulated, protective growth arrest, a controlled…
High-dose risankizumab induces rapid, deep skin clearance in moderate-to-severe psoriasis and sustains remission long after treatment stops, alongside a significant reduction in pathogenic tissue-resident memory T cells within former lesions, supporting its potential as a durable therapeutic option.
https://www.nature.com/articles/s41467-025-67475-0
https://redd.it/1q35pxp
@r_sciencegeeks
https://www.nature.com/articles/s41467-025-67475-0
https://redd.it/1q35pxp
@r_sciencegeeks
Nature
A randomized phase 2 clinical trial to treat moderate-to-severe plaque psoriasis patients with high-induction dosing of risankizumab
Nature Communications - Psoriasis is a difficult to treat chronic skin condition that could be limiting to quality of life. Here, authors present results of the phase 2 randomized clinical trial...
Bacteria inside tumors suppress the immune response, driving immunotherapy resistance. Head and neck cancer patients with high tumor bacteria levels had poorer outcomes with immunotherapy compared to standard chemoradiotherapy.
https://www.nature.com/articles/s43018-025-01067-1
https://redd.it/1q35msl
@r_sciencegeeks
https://www.nature.com/articles/s43018-025-01067-1
https://redd.it/1q35msl
@r_sciencegeeks
Nature
Intratumoral bacteria are immunosuppressive and promote immunotherapy resistance in head and neck squamous cell carcinoma
Nature Cancer - McGrail and colleagues report that high intratumoral bacteria abundance is associated with an immunosuppressive microenvironment and resistance to immune checkpoint blockade in head...