Researchers identify a previously unknown mechanism by which melanoma cancer cells paralyze immune cells through extracellular vesicle secretion, revealing a key strategy of immune evasion and offering new insights into potential immunotherapeutic targets for the deadliest form of skin cancer.
https://www.cell.com/cell/fulltext/S0092-8674(25)01316-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867425013169%3Fshowall%3Dtrue
https://redd.it/1pz1qpa
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https://www.cell.com/cell/fulltext/S0092-8674(25)01316-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867425013169%3Fshowall%3Dtrue
https://redd.it/1pz1qpa
@rnerds
Cell
HLA export by melanoma cells decoys cytotoxic T cells to promote immune evasion
Melanoma cells escape immune surveillance by releasing MHC-antigen-loaded large EVs,
known as melanosomes, that directly engage and impair CD8+ T cell receptors.
known as melanosomes, that directly engage and impair CD8+ T cell receptors.
A drug once designed for dengue virus, then quietly abandoned by industry, is suddenly back in the spotlight. Study suggests that this antiviral didn’t just slow the dengue virus, it blocked viral replication and significantly reduced infection rates at high doses.
https://www.nejm.org/doi/full/10.1056/NEJMoa2500179
https://redd.it/1pz4ls3
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https://www.nejm.org/doi/full/10.1056/NEJMoa2500179
https://redd.it/1pz4ls3
@rnerds
The New England Journal of Medicine
Daily Mosnodenvir as Dengue Prophylaxis in a Controlled Human Infection Model | NEJM
Approximately half the worldwide population is at risk for dengue. No antiviral prophylaxis
or treatment options are available. In a phase 2a, double-blind, randomized trial,
we assigned healthy ad...
or treatment options are available. In a phase 2a, double-blind, randomized trial,
we assigned healthy ad...
A low-fat vegan diet produced greater weight loss than a Mediterranean diet in a randomized crossover trial, driven mainly by eliminating animal foods and reducing oils and nuts, with weight loss linked to higher intake of plant foods, including refined grains and potatoes.
https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1666807/full
https://redd.it/1pz3cqr
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https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1666807/full
https://redd.it/1pz3cqr
@rnerds
Frontiers
Frontiers | Plant-based dietary index on the Mediterranean and a vegan diet: a secondary analysis of a randomized, cross-over trial
ObjectiveThe plant-based diet index (PDI) has been proposed as a gauge of diet healthfulness. This study assessed the relationship between the PDI, and the “...
When users swipe through profiles on dating apps, their brains make split-second decisions based on 2 cognitive processes: one assesses facial beauty and another interprets “vibe” or social context of photo. A beautiful face is an asset, but combined with displays of wealth or status can backfire.
https://www.sciencedirect.com/science/article/abs/pii/S0747563225002390
https://redd.it/1pzffeg
@rnerds
https://www.sciencedirect.com/science/article/abs/pii/S0747563225002390
https://redd.it/1pzffeg
@rnerds
Reddit
From the science community on Reddit: When users swipe through profiles on dating apps, their brains make split-second decisions…
Posted by mvea - 62 votes and 13 comments
Oral bacterium tied to disability severity in multiple sclerosis (MS). Findings connect Fusobacterium nucleatum with MS disease severity. Increasing evidence suggests that the severe gum disease, periodontitis, may contribute to central nervous system disorders through chronic inflammation.
https://www.hiroshima-u.ac.jp/en/news/94860
https://redd.it/1pzh493
@rnerds
https://www.hiroshima-u.ac.jp/en/news/94860
https://redd.it/1pzh493
@rnerds
Hiroshima University
Oral bacterium tied to disability severity in multiple sclerosis
Findings connect Fusobacterium nucleatum with MS disease severity
Analysis of income, capital gains, and borrowing of Americans finds 40% of the income of "1% wealth holders" is unrealized capital gains not subject to taxation and 1%-2% is borrowing, suggesting that the "Buy, Borrow, Die" is not a dominant tax avoidance strategy among the rich
https://www.sciencedirect.com/science/article/abs/pii/S0047272725002178
https://redd.it/1pzkhn8
@rnerds
https://www.sciencedirect.com/science/article/abs/pii/S0047272725002178
https://redd.it/1pzkhn8
@rnerds
Reddit
From the science community on Reddit: Analysis of income, capital gains, and borrowing of Americans finds 40% of the income of…
Posted by quiplaam - 334 votes and 169 comments
Biological roots of PTSD differ strikingly between men and women | Researchers found that men with the disorder primarily exhibit deficits in specific stress-regulating lipids, whereas women exhibit heightened signs of systemic inflammation.
https://www.psypost.org/biological-roots-of-ptsd-differ-strikingly-between-men-and-women/
https://redd.it/1pznn5s
@rnerds
https://www.psypost.org/biological-roots-of-ptsd-differ-strikingly-between-men-and-women/
https://redd.it/1pznn5s
@rnerds
PsyPost
Biological roots of PTSD differ strikingly between men and women
Researchers analyzing blood samples discovered that the biological mechanisms driving PTSD vary by sex, potentially explaining why some drug trials have failed to help female patients.
Doubting your doubts may increase commitment to goals: when people who were worried about achieving an identity goal were induced to experience a meta-cognitive doubt, they became more committed to achieving their goal
https://news.osu.edu/how-doubting-your-doubts-may-increase-commitment-to-goals/
https://redd.it/1pznbkl
@rnerds
https://news.osu.edu/how-doubting-your-doubts-may-increase-commitment-to-goals/
https://redd.it/1pznbkl
@rnerds
Ohio State News
How doubting your doubts may increase commitment to goals
Research explores what happens when people face goal obstacles
Mass shootings are associated with increased local voter turnout but do not change presidential vote choices, showing that exposure to gun violence mobilizes voters locally without producing broader shifts in national electoral outcomes.
https://www.science.org/doi/10.1126/sciadv.adx5418
https://redd.it/1pzrpxu
@rnerds
https://www.science.org/doi/10.1126/sciadv.adx5418
https://redd.it/1pzrpxu
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Science Advances
The effect of mass shootings on voter turnout in the United States
Following mass shootings, localized voter turnout increases, as does support for a gun reform ballot initiative.
Injectable antibodies in nanoparticles could replace hour-long infusions: A much faster, simpler treatment without an IV bag and an hour of getting needled. Just a single 2-ml shot of a solution containing solid nanoparticles packed with highly concentrated antibodies.
https://newatlas.com/medical-tech/injectable-antibodies-nanoparticles/
https://redd.it/1pzvxje
@rnerds
https://newatlas.com/medical-tech/injectable-antibodies-nanoparticles/
https://redd.it/1pzvxje
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New Atlas
Injectable antibodies in nanoparticles could replace hour-long infusions
I don’t know about you, but I’ve always preferred making my own antibodies.
Real estate investment trust (REIT)-acquired US hospitals were associated with a greater risk of bankruptcy or closure than non-REIT-acquired hospitals. Concern has grown that for-profit hospital owners are using REITs as a strategy to strip assets from hospitals to generate returns to investors.
https://hsph.harvard.edu/news/hospitals-acquired-by-real-estate-investment-trusts-associated-with-greater-risk-of-bankruptcy-closure/
https://redd.it/1pzygvo
@rnerds
https://hsph.harvard.edu/news/hospitals-acquired-by-real-estate-investment-trusts-associated-with-greater-risk-of-bankruptcy-closure/
https://redd.it/1pzygvo
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Harvard T.H. Chan School of Public Health
Hospitals acquired by real estate investment trusts associated with greater risk of bankruptcy, closure | Harvard T.H. Chan School…
REIT acquisition of hospitals had no significant impacts on quality of clinical care or patient outcomes—but had a significant negative impact on hospital finances, according to a new Harvard Chan School study.
Review highlights why Candida auris is becoming increasingly difficult to control, raising concerns for current infection prevention strategies
https://journals.asm.org/doi/10.1128/mmbr.00187-22
https://redd.it/1pzv5gh
@rnerds
https://journals.asm.org/doi/10.1128/mmbr.00187-22
https://redd.it/1pzv5gh
@rnerds
Microbiology and Molecular Biology Reviews
Candida auris: host interactions, antifungal drug resistance, and diagnostics | Microbiology and Molecular Biology Reviews
SUMMARYInvasive fungal infections affect approximately 6.5 million people every year. These
infections are frequently associated with high mortality rates, often exceeding 50%,
even with antifungal therapy. Candida auris is a multidrug-resistant fungal pathogen…
infections are frequently associated with high mortality rates, often exceeding 50%,
even with antifungal therapy. Candida auris is a multidrug-resistant fungal pathogen…
CTE Is Caused by More Than Head Trauma, New Study Suggests
https://hms.harvard.edu/news/cte-caused-by-more-than-head-trauma
https://redd.it/1q02mdc
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https://hms.harvard.edu/news/cte-caused-by-more-than-head-trauma
https://redd.it/1q02mdc
@rnerds
Updated Comprehensive Review finds that methylphenidate may reduce ADHD symptoms (inattention, hyperactivity) in children/adolescents, but evidence certainty is low. Non-serious side effects (sleep loss, appetite suppression) are common and long-term effects remain unclear.
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD009885.pub4/full
https://redd.it/1q076t0
@rnerds
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD009885.pub4/full
https://redd.it/1q076t0
@rnerds
Reddit
From the science community on Reddit: Updated Comprehensive Review finds that methylphenidate may reduce ADHD symptoms (inattention…
Posted by EnigmaticEmir - 28 votes and 17 comments
A Breakthrough on Modeling Cancer Prevention and Elimination by Low Radiation Doses
https://journals.sagepub.com/doi/10.1177/15593258251359335
https://redd.it/1q0fgdt
@rnerds
https://journals.sagepub.com/doi/10.1177/15593258251359335
https://redd.it/1q0fgdt
@rnerds
SAGE Journals
A Breakthrough on Modeling Cancer Prevention and Elimination by Low Radiation Doses
Background Previously the author was unable to develop a formal mathematical characterization of his probability-based hormetic relative risk (HRR) model for ca...
In the 1950s, Norwegian dairy firms began widely adopting milking machines to replace hand-milking, a task typically performed by young women. Rural young women subsequently moved to cities where they acquired more education and found better-paying, skilled employment.
https://www.aeaweb.org/articles?id=10.1257/aer.20240167
https://redd.it/1q0i11i
@rnerds
https://www.aeaweb.org/articles?id=10.1257/aer.20240167
https://redd.it/1q0i11i
@rnerds
www.aeaweb.org
Gender-Biased Technological Change: Milking Machines and the Exodus of Women from Farming
(January 2026) - This paper studies how gender-biased technological change in agriculture affected women's work in twentieth-century Norway. In the 1950s, dairy farms began widely adopting milking machines to replace milking cows by hand, a task typically…
Children exposed to high levels of screen time before age two showed changes in brain development that were linked to slower decision-making and increased anxiety by their teenage years
https://www.sgpc.gov.sg/detail?url=/media_releases/astar/press_release/P-20251230-2
https://redd.it/1q0hvig
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https://www.sgpc.gov.sg/detail?url=/media_releases/astar/press_release/P-20251230-2
https://redd.it/1q0hvig
@rnerds
Default
SG Press Centre
Singapore Government Press Centre
😱1
Two new subtypes of MS found in ‘exciting’ breakthrough. Scientists uncovered biological strands using artificial intelligence and hope discovery will revolutionise treatment.
https://www.theguardian.com/society/2025/dec/30/two-new-subtypes-of-ms-found-in-exciting-breakthrough
https://redd.it/1q0jmy7
@rnerds
https://www.theguardian.com/society/2025/dec/30/two-new-subtypes-of-ms-found-in-exciting-breakthrough
https://redd.it/1q0jmy7
@rnerds
the Guardian
Two new subtypes of MS found in ‘exciting’ breakthrough
Exclusive: Scientists uncovered biological strands using artificial intelligence and hope discovery will revolutionise treatment
Mindfulness meditation practiced daily for 30 days improves attention control across all ages. Eye-tracking shows faster reactions, stronger focus on relevant targets, and less distraction, indicating that mindfulness doesn’t just promote relaxation but actively strengthens attention control.
https://www.eneuro.org/content/12/7/ENEURO.0356-23.2025
https://redd.it/1q0m1g3
@rnerds
https://www.eneuro.org/content/12/7/ENEURO.0356-23.2025
https://redd.it/1q0m1g3
@rnerds
eNeuro
The Effects of Mindfulness Meditation on Mechanisms of Attentional Control in Young and Older Adults: A Preregistered Eye Tracking…
Neuroimaging data reveal that a functional locus ceruleus-noradrenaline (LC-NA) system is critical in maintaining cognitive performance during aging. However, older adults show reduced LC integrity and altered functional connectivity, demonstrating both structural…
Mindfulness meditation practiced daily for 30 days improves attention control across all ages. Eye-tracking shows faster reactions, stronger focus on relevant targets, and less distraction, indicating that mindfulness doesn’t just promote relaxation but actively strengthens attention control.
https://www.eneuro.org/content/12/7/ENEURO.0356-23.2025
https://redd.it/1q0m1g3
@rnerds
https://www.eneuro.org/content/12/7/ENEURO.0356-23.2025
https://redd.it/1q0m1g3
@rnerds
eNeuro
The Effects of Mindfulness Meditation on Mechanisms of Attentional Control in Young and Older Adults: A Preregistered Eye Tracking…
Neuroimaging data reveal that a functional locus ceruleus-noradrenaline (LC-NA) system is critical in maintaining cognitive performance during aging. However, older adults show reduced LC integrity and altered functional connectivity, demonstrating both structural…
Microdosing psychedelics linked to better sleep and exercise habits. Research indicates that people who microdose report improvements in sleep, physical activity, and diet, particularly when they start the regimen with a specific goal in mind.
https://www.psypost.org/microdosing-psychedelics-linked-to-better-sleep-and-exercise-habits/
https://redd.it/1q0p83t
@rnerds
https://www.psypost.org/microdosing-psychedelics-linked-to-better-sleep-and-exercise-habits/
https://redd.it/1q0p83t
@rnerds
PsyPost
Microdosing psychedelics linked to better sleep and exercise habits
Researchers report that microdosing is associated with positive lifestyle shifts, such as better diet and reduced alcohol consumption. The findings suggest low doses might support the psychological mechanisms required for habit change.