✅ Answer: B) Add a dopamine agonist
📘 Lesson:
After several years of treatment with levodopa, many Parkinson’s patients develop motor fluctuations, such as “wearing off”, where the medication effect declines before the next dose. This is part of the “on-off phenomenon”. Management includes strategies like:
Adding a dopamine agonist (e.g., pramipexole, ropinirole)
Using MAO-B inhibitors (e.g., selegiline, rasagiline)
COMT inhibitors (e.g., entacapone) to prolong levodopa’s half-life
Shortening dosing intervals or switching to extended-release formulations may also help. The goal is to smooth out dopamine stimulation and reduce fluctuations.
📚 References:
Fox SH et al. The Movement Disorder Society Evidence-Based Review of Treatments for Parkinson’s Disease. Mov Disord. 2011.
Stocchi F, Olanow CW. Motor Fluctuations in Parkinson’s Disease. Lancet Neurol. 2004.
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📘 Lesson:
After several years of treatment with levodopa, many Parkinson’s patients develop motor fluctuations, such as “wearing off”, where the medication effect declines before the next dose. This is part of the “on-off phenomenon”. Management includes strategies like:
Adding a dopamine agonist (e.g., pramipexole, ropinirole)
Using MAO-B inhibitors (e.g., selegiline, rasagiline)
COMT inhibitors (e.g., entacapone) to prolong levodopa’s half-life
Shortening dosing intervals or switching to extended-release formulations may also help. The goal is to smooth out dopamine stimulation and reduce fluctuations.
📚 References:
Fox SH et al. The Movement Disorder Society Evidence-Based Review of Treatments for Parkinson’s Disease. Mov Disord. 2011.
Stocchi F, Olanow CW. Motor Fluctuations in Parkinson’s Disease. Lancet Neurol. 2004.
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📌 National Epilepsy Awareness Month 2025
📆 November 2025
📍 United States
🔅 Key Message:
“End the Stigma. Expand the Understanding.”
Every November, National Epilepsy Awareness Month raises global understanding of epilepsy — one of the most common neurological conditions in the world. This month is dedicated to supporting individuals living with epilepsy, educating communities about seizure first-aid, and promoting advances in research and treatment.
🔶 HIGHLIGHTS:
🔸 Increasing public awareness of epilepsy and seizure disorders
🔸 Encouraging stigma reduction and community education
🔸 Promoting research for improved therapies and long-term management
#EpilepsyAwareness
#SeizureFirstAid
#BRAINet
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📆 November 2025
📍 United States
🔅 Key Message:
“End the Stigma. Expand the Understanding.”
Every November, National Epilepsy Awareness Month raises global understanding of epilepsy — one of the most common neurological conditions in the world. This month is dedicated to supporting individuals living with epilepsy, educating communities about seizure first-aid, and promoting advances in research and treatment.
🔶 HIGHLIGHTS:
🔸 Increasing public awareness of epilepsy and seizure disorders
🔸 Encouraging stigma reduction and community education
🔸 Promoting research for improved therapies and long-term management
#EpilepsyAwareness
#SeizureFirstAid
#BRAINet
—————————————
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❤1
📌Global Conference on Neurology and Brain Disorder (Annual Neurology 2026)
📍Rome, Italy (plus virtual)
📆 16-17 July 2026 (in-person in Rome, Italy) + 18 July virtual.
🔅Key features:
🔶️Theme:Annual Neurology: Connecting Research, Treatment, and Patient Care
🔷️multidisciplinary neurology meeting; abstract submissions accepted in multiple rounds; good for research/clinical interface.
🔎More info
#event
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📍Rome, Italy (plus virtual)
📆 16-17 July 2026 (in-person in Rome, Italy) + 18 July virtual.
🔅Key features:
🔶️Theme:Annual Neurology: Connecting Research, Treatment, and Patient Care
🔷️multidisciplinary neurology meeting; abstract submissions accepted in multiple rounds; good for research/clinical interface.
🔎More info
#event
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📌 Dr. Pasko Rakic
🖋 Identified radial glia as scaffolds for neuronal migration.
🖋 Explained inside‑out formation of cortical layers.
🖋 Defined principles of cortical arealization and microcolumns.
🖋 Timed neurogenesis with birth‑dating methods.
🖋 Linked developmental errors to neurodevelopmental disorders.
—————————————
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🖋 Identified radial glia as scaffolds for neuronal migration.
🖋 Explained inside‑out formation of cortical layers.
🖋 Defined principles of cortical arealization and microcolumns.
🖋 Timed neurogenesis with birth‑dating methods.
🖋 Linked developmental errors to neurodevelopmental disorders.
—————————————
📍 Join us in BRAINet
☑️ Telegram: @theBRAINet
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☑️ Email: brainet.neuroscience@gmail.com
☑️ Website: theBRAINet.org
📌Brain Tumor Symposium 2026
📍Copenhagen, Denmark
📆 9‑10 April 2026
🔅Key features:
🔶️Theme:Advancing Brain Tumor Research: Innovation, Collaboration, and Patient‑Centered Care
🔷️The symposium is organised as a collaboration between the Scandinavian Neuro‑oncology (SNOG) symposia (leading meeting in Nordic neuro‑oncology) and the Northern Lights Neuroscience Symposia (leading Nordic meeting in neuropathology). It is an interdisciplinary meeting aimed at sharing cutting‑edge results and fostering collaborations in the fight against brain cancer.
🔎More info
#event
—————————————
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📍Copenhagen, Denmark
📆 9‑10 April 2026
🔅Key features:
🔶️Theme:Advancing Brain Tumor Research: Innovation, Collaboration, and Patient‑Centered Care
🔷️The symposium is organised as a collaboration between the Scandinavian Neuro‑oncology (SNOG) symposia (leading meeting in Nordic neuro‑oncology) and the Northern Lights Neuroscience Symposia (leading Nordic meeting in neuropathology). It is an interdisciplinary meeting aimed at sharing cutting‑edge results and fostering collaborations in the fight against brain cancer.
🔎More info
#event
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📌12th European Stroke Organisation Conference (ESOC) 2026
📍Maastricht, The Netherlands
📆 6–8 May 2026
🔅Key features:
🔶️Theme:Advancing Stroke Science and Care: Innovation, Collaboration, and Global Impact
🔷️Leading international platform for stroke research, clinical advances, and innovation.
Abstract submission categories: Regular, Young Stroke Physician/Researcher (YSPR), Large Clinical Trials, Ongoing Trials, Late-Breaking Science.Travel grants and awards for young investigators.
Accepted abstracts published with embargo policy until 6 May 2026.
Emphasis on translational science, neurorehabilitation, acute stroke interventions, prevention, and health system improvements.
🔎More info
#event
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📍Maastricht, The Netherlands
📆 6–8 May 2026
🔅Key features:
🔶️Theme:Advancing Stroke Science and Care: Innovation, Collaboration, and Global Impact
🔷️Leading international platform for stroke research, clinical advances, and innovation.
Abstract submission categories: Regular, Young Stroke Physician/Researcher (YSPR), Large Clinical Trials, Ongoing Trials, Late-Breaking Science.Travel grants and awards for young investigators.
Accepted abstracts published with embargo policy until 6 May 2026.
Emphasis on translational science, neurorehabilitation, acute stroke interventions, prevention, and health system improvements.
🔎More info
#event
—————————————
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📌 Dr. György Buzsáki
🖋 Mapped hippocampal theta, gamma, and sharp‑wave ripples in memory.
🖋 Revealed sequence replay/preplay for planning and consolidation.
🖋 Pioneered high‑density, multi‑site recordings in behaving animals.
🖋 Showed oscillations coordinate cell assemblies across networks.
🖋 Author of Rhythms of the Brain, shaping circuit neuroscience.
—————————————
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🖋 Mapped hippocampal theta, gamma, and sharp‑wave ripples in memory.
🖋 Revealed sequence replay/preplay for planning and consolidation.
🖋 Pioneered high‑density, multi‑site recordings in behaving animals.
🖋 Showed oscillations coordinate cell assemblies across networks.
🖋 Author of Rhythms of the Brain, shaping circuit neuroscience.
—————————————
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☑️ Email: brainet.neuroscience@gmail.com
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❤2
International Conference on Psychiatry, Mental Health and Neuroscience (ICPMHN-26)
📍 Dallas, USA
📆 January 3, 2026
🔅 Highlights:
🔶️ Theme: Advancing global dialogue in psychiatry, mental health, and neuroscience.
🔷️ Focus: Groundbreaking research, tech advancements, and interdisciplinary collaboration. Features keynote addresses, interactive workshops, and networking.
🔎More info
#event
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☑️ Website: theBRAINet.org
📍 Dallas, USA
📆 January 3, 2026
🔅 Highlights:
🔶️ Theme: Advancing global dialogue in psychiatry, mental health, and neuroscience.
🔷️ Focus: Groundbreaking research, tech advancements, and interdisciplinary collaboration. Features keynote addresses, interactive workshops, and networking.
🔎More info
#event
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❤1
📌 14th Annual Alzheimer's & Parkinson's Drug Development Summit
📍 Boston, MA
📆 February 3-5, 2026
🔅 Key features:
🔶️ Theme: Discovering, Translating & Clinically Advancing Novel Targets, Building on Anti-Amyloid Approvals & Strengthening Endpoints, to Reinvigorate the Neurodegenerative Treatment Landscape.
🔷️ This summit focuses on the latest innovations in Alzheimer's and Parkinson's treatment, from discovering novel therapeutic targets to advancements in diagnostics (like blood-based tests) and clinical challenges. It provides a platform for knowledge exchange and collaboration among experts in the field.
🔎More info
#event
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☑️ Website: theBRAINet.org
📍 Boston, MA
📆 February 3-5, 2026
🔅 Key features:
🔶️ Theme: Discovering, Translating & Clinically Advancing Novel Targets, Building on Anti-Amyloid Approvals & Strengthening Endpoints, to Reinvigorate the Neurodegenerative Treatment Landscape.
🔷️ This summit focuses on the latest innovations in Alzheimer's and Parkinson's treatment, from discovering novel therapeutic targets to advancements in diagnostics (like blood-based tests) and clinical challenges. It provides a platform for knowledge exchange and collaboration among experts in the field.
🔎More info
#event
—————————————
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❤1
📌 Dr. Seiji Ogawa
🖋 Discovered the BOLD signal, enabling modern fMRI.
🖋 Linked deoxyhemoglobin to MR signal changes with neural activity.
🖋 Sparked noninvasive human brain mapping at scale.
🖋 Advanced high‑field MRI methodology.
🖋 Made circuit‑level imaging routine in research and clinics.
—————————————
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☑️ Website: theBRAINet.org
🖋 Discovered the BOLD signal, enabling modern fMRI.
🖋 Linked deoxyhemoglobin to MR signal changes with neural activity.
🖋 Sparked noninvasive human brain mapping at scale.
🖋 Advanced high‑field MRI methodology.
🖋 Made circuit‑level imaging routine in research and clinics.
—————————————
📍 Join us in BRAINet
☑️ Telegram: @theBRAINet
☑️ Instagram: @theBRAINet
☑️ Email: brainet.neuroscience@gmail.com
☑️ Website: theBRAINet.org
❤2
📌 European Symposium on Practical Neuroradiology: Insight to Impact
📍 The College Green Hotel Dublin, Dublin, Ireland
📆 April 27 - May 1, 2026
🔅 Key features:
🔶️ Theme: Insight to Impact - A practical educational experience for neuroradiologists and radiologists.
🔷️ This Mayo Clinic symposium offers expert lectures and case-based learning to enhance diagnostic confidence.
🔷️ Topics: Covers neuro-oncology, spine, vascular, pediatric, and neurodegenerative imaging, focusing on practical application and emerging trends.
🔷️ Learning Objectives: Gain insights into brain tumor classification, cerebral veins, pediatric facial trauma, spinal CSF leaks, and autoimmune encephalopathies.
🔎More info
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☑️ Website: theBRAINet.org
📍 The College Green Hotel Dublin, Dublin, Ireland
📆 April 27 - May 1, 2026
🔅 Key features:
🔶️ Theme: Insight to Impact - A practical educational experience for neuroradiologists and radiologists.
🔷️ This Mayo Clinic symposium offers expert lectures and case-based learning to enhance diagnostic confidence.
🔷️ Topics: Covers neuro-oncology, spine, vascular, pediatric, and neurodegenerative imaging, focusing on practical application and emerging trends.
🔷️ Learning Objectives: Gain insights into brain tumor classification, cerebral veins, pediatric facial trauma, spinal CSF leaks, and autoimmune encephalopathies.
🔎More info
#event
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📌AD/PD™ 2026 Alzheimer’s & Parkinson’s Diseases Conference
📍Copenhagen , Denmark
📆 17–21 March 2026
🔅Key features:
🔶️Theme:Striving for a better future for all those affected by neurodegenerative diseases
🔷️A leading global meeting in the field of neurodegenerative diseases (Alzheimer’s, Parkinson’s & related disorders) with a multidisciplinary audience.Program covering disease mechanisms, prevention, translational & clinical research, early diagnosis, therapeutic innovation.
🔎More info
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📍Copenhagen , Denmark
📆 17–21 March 2026
🔅Key features:
🔶️Theme:Striving for a better future for all those affected by neurodegenerative diseases
🔷️A leading global meeting in the field of neurodegenerative diseases (Alzheimer’s, Parkinson’s & related disorders) with a multidisciplinary audience.Program covering disease mechanisms, prevention, translational & clinical research, early diagnosis, therapeutic innovation.
🔎More info
#event
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📌 Dr. Carla J. Shatz
🖋 Proved correlated activity (retinal waves) instructs visual wiring.
🖋 Established activity‑dependent synapse elimination in critical periods.
🖋 Revealed roles for immune molecules (MHC I) in CNS plasticity.
🖋 Connected development to learning and disease.
🖋 Leader in interdisciplinary training and neuroscience policy.
—————————————
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🖋 Proved correlated activity (retinal waves) instructs visual wiring.
🖋 Established activity‑dependent synapse elimination in critical periods.
🖋 Revealed roles for immune molecules (MHC I) in CNS plasticity.
🖋 Connected development to learning and disease.
🖋 Leader in interdisciplinary training and neuroscience policy.
—————————————
📍 Join us in BRAINet
☑️ Telegram: @theBRAINet
☑️ Instagram: @theBRAINet
☑️ Email: brainet.neuroscience@gmail.com
☑️ Website: theBRAINet.org
📌 International Conference on Molecular Genetics and Neurobiology (ICMNG-25)
📍 Las Vegas, USA
📆 15th - 16th November 2025
🔶️ Theme: Advancing Molecular Neurobiology and Genetics through Global Knowledge Sharing.
🔷️ What to Expect:
🔹️ Dissemination of Research: Get the latest findings and knowledge.
🔹️ Collaboration Focus: Bringing leaders together to overcome barriers and boost research collaboration.
🔹️ Diverse Program: Engaging lectures, panel discussions, presentations, and workshops.
🔹️ Target Audience: Professionals, researchers, and students in the field.
🔎More info
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☑️ Website: theBRAINet.org
📍 Las Vegas, USA
📆 15th - 16th November 2025
🔶️ Theme: Advancing Molecular Neurobiology and Genetics through Global Knowledge Sharing.
🔷️ What to Expect:
🔹️ Dissemination of Research: Get the latest findings and knowledge.
🔹️ Collaboration Focus: Bringing leaders together to overcome barriers and boost research collaboration.
🔹️ Diverse Program: Engaging lectures, panel discussions, presentations, and workshops.
🔹️ Target Audience: Professionals, researchers, and students in the field.
🔎More info
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☑️ Website: theBRAINet.org
📌 International Conference on Mental Health and Psychiatry 2026
📍 Paris, France
📆 18-19 May 2026
🔅 Key features:
🔶️ Theme: Advancing Global Mental Health and Psychiatry.
🔷️ Multidisciplinary (psychiatry, medical, science, technology), includes conferences, symposiums, workshops, oral & poster presentations; features experts from top institutions; promotes collaboration, networking, and journal publication of abstracts.
🔎More info
#event
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📍 Paris, France
📆 18-19 May 2026
🔅 Key features:
🔶️ Theme: Advancing Global Mental Health and Psychiatry.
🔷️ Multidisciplinary (psychiatry, medical, science, technology), includes conferences, symposiums, workshops, oral & poster presentations; features experts from top institutions; promotes collaboration, networking, and journal publication of abstracts.
🔎More info
#event
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📌 Dr. Ben A. Barres
🖋 Showed astrocytes drive synapse formation and function.
🖋 Defined oligodendrocyte lineage biology and neuron–glia signaling.
🖋 Reframed glia as active circuit regulators, not just support cells.
🖋 Powerful advocate for equity and open science.
🖋 His lab’s tools transformed neurodevelopment and disease research.
—————————————
📍 Join us in BRAINet
☑️ Telegram: @theBRAINet
☑️ Instagram: @theBRAINet
☑️ Email: brainet.neuroscience@gmail.com
☑️ Website: theBRAINet.org
🖋 Showed astrocytes drive synapse formation and function.
🖋 Defined oligodendrocyte lineage biology and neuron–glia signaling.
🖋 Reframed glia as active circuit regulators, not just support cells.
🖋 Powerful advocate for equity and open science.
🖋 His lab’s tools transformed neurodevelopment and disease research.
—————————————
📍 Join us in BRAINet
☑️ Telegram: @theBRAINet
☑️ Instagram: @theBRAINet
☑️ Email: brainet.neuroscience@gmail.com
☑️ Website: theBRAINet.org
📌 12th International Conference on Neurology and Neurological Disorders
📍 Barcelona, Spain & Virtual
📆 June 22-24, 2026
🔅 Key features:
🔶️ Theme: Connecting Minds: Innovations in Neurology and Patient Care.
🔷️ Multidisciplinary (neurology, neuroscience, neuropharmacology, neurogenetics), includes plenary talks, oral & virtual poster presentations; focuses on translational research, neurodegenerative disorders, and brain health; promotes global collaboration and evidence-based practice.
🔎More info
#event
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☑️ Email: brainet.neuroscience@gmail.com
☑️ Website: theBRAINet.org
📍 Barcelona, Spain & Virtual
📆 June 22-24, 2026
🔅 Key features:
🔶️ Theme: Connecting Minds: Innovations in Neurology and Patient Care.
🔷️ Multidisciplinary (neurology, neuroscience, neuropharmacology, neurogenetics), includes plenary talks, oral & virtual poster presentations; focuses on translational research, neurodegenerative disorders, and brain health; promotes global collaboration and evidence-based practice.
🔎More info
#event
—————————————
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☑️ Website: theBRAINet.org
📌 International Conference on Neuroinflammation and Neuroimmune Disorders (ICNIND-26)
📍 Liège, Belgium
📆 January 13-14, 2026
🔅 Key features:
🔶️ Theme: Advancing Research and Policies in Neuroinflammation and Neuroimmune Disorders.
🔷️ Multidisciplinary (neuroimmunology, neuroscience, clinical research), includes expert presentations, networking sessions; focuses on global knowledge sharing, policy development, and personal advancement in studies, research, and careers; promotes ethics, professionalism, and collaboration.
🔎 More info
#event
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☑️ Email: brainet.neuroscience@gmail.com
☑️ Website: theBRAINet.org
📍 Liège, Belgium
📆 January 13-14, 2026
🔅 Key features:
🔶️ Theme: Advancing Research and Policies in Neuroinflammation and Neuroimmune Disorders.
🔷️ Multidisciplinary (neuroimmunology, neuroscience, clinical research), includes expert presentations, networking sessions; focuses on global knowledge sharing, policy development, and personal advancement in studies, research, and careers; promotes ethics, professionalism, and collaboration.
🔎 More info
#event
—————————————
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☑️ Telegram: @theBRAINet
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☑️ Email: brainet.neuroscience@gmail.com
☑️ Website: theBRAINet.org
📌 Dr. Eve Marder
🖋 Used the stomatogastric ganglion to reveal principles of neuromodulation.
🖋 Demonstrated degeneracy—different circuit parameters yield similar outputs.
🖋 Helped develop the dynamic‑clamp method.
🖋 Unified computational and experimental views of circuit robustness.
🖋 Defined how neuromodulators reconfigure networks for behavior.
—————————————
📍 Join us in BRAINet
☑️ Telegram: @theBRAINet
☑️ Instagram: @theBRAINet
☑️ Email: brainet.neuroscience@gmail.com
☑️ Website: theBRAINet.org
🖋 Used the stomatogastric ganglion to reveal principles of neuromodulation.
🖋 Demonstrated degeneracy—different circuit parameters yield similar outputs.
🖋 Helped develop the dynamic‑clamp method.
🖋 Unified computational and experimental views of circuit robustness.
🖋 Defined how neuromodulators reconfigure networks for behavior.
—————————————
📍 Join us in BRAINet
☑️ Telegram: @theBRAINet
☑️ Instagram: @theBRAINet
☑️ Email: brainet.neuroscience@gmail.com
☑️ Website: theBRAINet.org
❤1
World Neuroscience and Psychiatry Conference 2026 (WNPC26)
📍 Bangkok, Thailand
📆 March 06–07, 2026
🔅 Highlights:
🔶️ Theme: Unraveling the Brain: Innovations in Neuroscience & Psychiatry
🔷️ Focus: Neuroscience, psychiatry, neurology; keynotes, oral/poster presentations. Topics: brain injury, stroke, dementia, neuroimaging, neuropharmacology, mental health.
🔎More info
#event
—————————————
📍 Join us in BRAINet
☑️ Telegram: @theBRAINet
☑️ Instagram: @theBRAINet
☑️ Email: brainet.neuroscience@gmail.com
☑️ Website: theBRAINet.org
📍 Bangkok, Thailand
📆 March 06–07, 2026
🔅 Highlights:
🔶️ Theme: Unraveling the Brain: Innovations in Neuroscience & Psychiatry
🔷️ Focus: Neuroscience, psychiatry, neurology; keynotes, oral/poster presentations. Topics: brain injury, stroke, dementia, neuroimaging, neuropharmacology, mental health.
🔎More info
#event
—————————————
📍 Join us in BRAINet
☑️ Telegram: @theBRAINet
☑️ Instagram: @theBRAINet
☑️ Email: brainet.neuroscience@gmail.com
☑️ Website: theBRAINet.org