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the Turing Machine
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Join me through the journey of learning Computational Neuroscience topics.
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Get in touch: @nosratullah
Website: nosratullah.github.io
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Mindful brains, By Emma Twait and Tzipi Horowitz-Kraus

In the world with so much buzz around us, it can be difficult to unplug from
work and not think about the never-ending list of things to do. Stress
accumulates…. If you can relate to

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GEM 2021
Feb 16 - 18 2021

Episodic memories are widely regarded as memories of personally experienced events. Early concepts about episodic memory were based on the storage model, according to which experiential content is preserved in memory and later retrieved. However, overwhelming empirical evidence suggests that the content of episodic memory is – at least to a certain degree – constructed in the act of remembering. Even though very few contemporary researchers would oppose this view of episodic memory as a generative process, it has not become the standard paradigm of empirical memory research. This is particularly true for studies of the neural correlates of episodic memory. Further hindering progress are large conceptual differences regarding episodic memory across different fields, such as neuroscience, philosophy, and psychology....

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Neural Stem Cells Direct Axon Guidance via Their Radial Fiber Scaffold

Kaur et al. show that the radial glial scaffold of neural stem cells from
medial ganglionic eminence directs corticospinal and other axons through a
previously unknown choice point at the striatopallidal junction in an
RND3/ARHGAP35-dependent manner. Within corticospinal neurons, FEZF2-dependent
Rnd3 expression regulates dendritic spinogenesis, axon elongation, and pontine
midline crossing.

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Enhancing gesture decoding performance using signals from posterior parietal cortex: a
stereo-electroencephalograhy (SEEG) study


Objective . Hand movement is a crucial function for humans’ daily life.
Developing brain-machine interface (BMI) to control a robotic hand by brain
signals would help the severely paralyzed people partially regain the
functional independence. Previous intracranial electroencephalography
(iEEG)-based BMIs towards gesture decoding mostly used neural signals from the
primary sensorimotor cortex while ignoring the hand movement related signals
from posterior parietal cortex (PPC). Here, we propose combining iEEG
recordings from PPC with that from primary sensorimotor cortex to enhance the
gesture decoding performance of iEEG-based BMI. Approach .
Stereoelectroencephalography (SEEG) signals from 25 epilepsy subjects were
recorded when they performed a three-class hand gesture task. Across all 25
subjects, we identified 524, 114 and 221 electrodes from three regions of
interest (ROIs), including PPC, postcentral cortex (POC) and precentral cortex
(PRC), respectively. Base...

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The relationship between morphological properties and thresholds to extracellular electric
stimulation in α RGCs


Objective . Retinal prostheses strive to restore vison to patients that are
blind from retinal degeneration by electrically stimulating surviving retinal
ganglion cells (RGCs). The quality of elicited percepts remains limited
however and it is desirable to develop improved stimulation strategies. Here,
we examine how the anatomical and biophysical properties of RGCs influence
activation thresholds, including the effects of variations found naturally.
Approach . Detailed reconstructions were made of a large number of mouse α
RGCs and were used to create an array of model cells; the models were used to
study the effects of individual anatomical features on activation threshold to
electric stimulation. Stimulation was delivered epiretinally from a point-
source or disk electrode and consisted of monophasic or biphasic rectangular
pulses. Main results. Modeling results show that the region of minimum
threshold always is within the axon initial segment (AIS)...

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Forwarded from Sci-Hub
schwartz2008.pdf
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Schwartz, M. A. (2008). The importance of stupidity in scientific research. Journal of Cell Science, 121(11), 1771–1771. doi:10.1242/jcs.033340
Brain Inspired

David, Gyuri, and I discuss the issues they argue for in their back and forth commentaries about the importance of neuroscience and psychology, or implementation-level and computational-level, to advance our understanding of brains and minds – and the names we give to the things we study. Gyuri believes it’s time we use what we know and discover about brain mechanisms to better describe the psychological concepts we refer to as explanations for minds; David believes the psychological concepts are constantly being refined and are just as valid as objects of study to understand minds. They both agree these are important and enjoyable topics to debate.

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#Neuroscience #Podcast

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Generative Episodic Memory: Interdisciplinary perspectives from neuroscience, psychology and philosophy
Episodic memories are widely regarded as memories of personally experienced events. Early concepts about episodic memory were based on the storage model, according to which experiential content is preserved in memory and later retrieved. However, overwhelming empirical evidence suggests that the content of episodic memory is – at least to a certain degree – constructed in the act of remembering. Even though very few contemporary researchers would oppose this view of episodic memory as a generative process, it has not become the standard paradigm of empirical memory research. This is particularly true for studies of the neural correlates of episodic memory. Further hindering progress are large conceptual differences regarding episodic memory across different fields, such as neuroscience, philosophy, and psychology. This interdisciplinary workshop therefore aims to bring together researchers from all relevant fields to advance the state of the art in the research on generative episodic memory.

Link:
https://easychair.org/cfp/gem2021