Humans are overvalued 😆😆😆

Meet the podcast with ChatGPT.

It's not just a podcast it's a podcast led by Reid Hoffman (PayPal/LinkedIn/Greylock)

https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5zb3VuZGNsb3VkLmNvbS91c2Vycy9zb3VuZGNsb3VkOnVzZXJzOjIwNTMyMzI1NC9zb3VuZHMucnNz/episode/dGFnOnNvdW5kY2xvdWQsMjAxMDp0cmFja3MvMTQyMTc4NTkyNA?ep=14

The changes in the way we work will be massive. The only way people will be able to outperform AI is through imagination. The use of Psychedelics will probably be the only option to compete. There is no way we will be able to do it without it. It's not the question of IF anymore. It's When. I just realized that Proposal 122 ( decriminalization of multiple Psychedelics including DMT ) and the release of ChatGPT both happened almost at the same time in late November 2022. Remember this date. This is fucking huge.

DMTx

it's going to be massive

"The DMTx extended peak would be five times stronger than Ayahuasca and can theoretically last many hours.  The acceleration of the entry, the intensity of the peak, and the duration of the DMT experience can literally be programed, or “dialed-in,” even adjusted during the experience, for different therapeutic, advanced problem solving, and consciousness explorations experiences. It can be quickly “turned off” if any safety concerns become apparent, therefore it is unlike any psychedelic experience previously possible."

https://www.dmtx.org/

3D Organoid Models Show Brain Mechanisms of Tourette Syndrome - Neuroscience News

I want to play with brain organoids, just curious how complex is is for a home-lab in a "backyard/kitchen" 😆

https://neurosciencenews.com/tourette-brain-organoid-22281/

Psychedelic-Assisted Therapy 101

===== Momentum (Why?)

> Triggers:

1. Rick Dubin’s FDA 3rd-stage MDMA
2. Relatively successful Cannabis history and results
3. Increased practical experience in Mexican/Peruvian/African rituals
4. Post-pandemic growth in mental issues

> As a result:

New trails
Hundreds of research papers
TED talks
Popular Books ( How to Change Mind)
Documentaries ( Netflix How to Change Mind )
Media and Celebs ( Mike Tyson, Joe Rogan, Prince Harry, Oxxymiron)
Legalization/Decriminalization(Oregon, Colorado)


===== Simplified mechanism and applications (What)

Think of it as surgery for the brain, we need it sometimes to fix issues that we can’t fix other way

Mechanism (simplified): Serotonin 5ht2-A receptor

As a result:

- default mode network ( where all concepts are stored, the more we take psychedelics more concepts will be temporarily deleted; if we turn it off completely, we will feel Ego dissolution)
- mental flexibility (psychological and cognitive [Like you are stuck in a negative pattern and now can understand it and move further ].
- neuroplasticity (reorganize structure, Form new connections, increase the capacity of change) [as a result, you can rewrite some patterns ]

Analog: Disassembler for a brain


Current applications:


Phase 3 or a lot of anecdotal or historical evidence

- depression ( Psilocybin, Ketamine, Ayahuasca)
- end of life and goals, terminal sickness (DMT, Psilocybin
- PTSD trauma (MDMA)
- use disorder (Ayahuasca, Psilocybin
- anxeety (MDMA , Psylcybin)

Phase 2

- chronic pain ( Psylocybin)
- eating disorder ( MDMA)
-ADHD ( LSD-like)
-cluster headache, migraine ( LSD-like)

Phase 1

- Alzimers ( LSD -like )
- Autism ( MDMA- like )
- OCD ( Psylocybin- like )



===== Who ( Experts and Evangelists)


All of them are valuable sources: Shamans, Psychonauts, Neuroscientists, Psychologists.

Popular people:

MDMA - Rick Doblin, Alex Shulgin
Psylocybin - Paul Stemets
DMT - Rick Strassman, McKenna
LSD - Timothy Leary, Ram Dass
All- Hamilton Morris (Hamiltons Pharmacopeia)

Organizations:

MAPS
Johns Hopkins University
ThirdWave


====== Super Short History (When )

1. First wave

Shamans, berserks, woodo, etc…..

2. Second Wave

1960-70 Mushrooms in USA + LSD


3. Third Wave

2006 - Johns Hopkins Psilocybin research no harm
2010 - MAPS first clinical trial of MDMA Therapy 73% cured
2010-2020 100 clinical trials of Psilocybin / MDMA /LSD
2017 - FDA for MDMA - Breakthrough Status
2019 - FDA for Psilocybin - Breakthrough Status


====== Legal options (Where)

USA:
Oregon ( from 2020 Legal Psilocybin )
Denver, Colorado (Nov 30 2022, Proposition 122, Psilocybin, Ibogaine, DMT, Mescaline )
California ( Dec 16 2022, SB 58, Psilocybin, Ibogaine, DMT, Mescaline)


Canada ( Psilocybin)
Amsterdam ( Psilocybin, Some MDMA-like)
Peru ( Ayahuasca, Mescaline )
Mexico ( Mescaline)
Bali/Gili (Psilocybin?)
Google for more


====== Process ( How )

Set setting size

Yes:
- Mental issues proved by a doctor after unsuccessful results with regular drugs (Antidepressants, etc)

No:
- kids
- sickness ( Bipolar, Schizophrenia, Neyroticasm)
- Currently on meds (SSRI, etc)

Options:

1. Microdoses, very popular as start (Psylocibin, LSD)
2. Normal dose, usually used (Anything)
3. Heroic Dose, mostly for complex issues ( DMT, Psilocybin )

Process:

1. Prepare/plan ( Prepare as you go on a long vacation to Alaska)
-personal traits ( do you like more music /less music)
- intention!!!!!! ( set some goals)
- set (relaxed, curious, healthy, rested)
2. Use
- sitter (experienced)
- supplies (water etc..)
- setting ( environment)
3. Integration
- distill insights the next day
- support behavior next 2-6 months


====== Future

Ongoing research:

- better setting ( special music)
- new legal molecules ( CMPS Psilocybin analogs)
- trip stoppers ( change the duration of the trip)
- VR-assisted ( for inducing a particular effect or preparing)
- nun-hallucinogenic compounds ( who are scared of hallucinations)
- DMT worlds mappings and exploration (WTF are those entities)

2023 Starts With Psychedelic Decrim Measures In Several States.


Washington, Illinois, Virginia... Who is next?


https://microdose.buzz/news/2023-starts-with-psychedelic-decrim-measures-in-several-states/

New Nanoparticles Deliver Therapy Brain-Wide and Edit Alzheimer’s Gene - Neuroscience News

Researchers have developed a new family of nano-scale capsules capable of carrying CRISPR gene editing tools to different organs of the body before harmlessly dissolving. The capsules were able to enter the brains of mice and successfully edit a gene associated with Alzheimer’s disease.


https://neurosciencenews.com/nanoparticle-crispr-alzheimers-22306/

Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms | Pharmacological Review

Looks like the most comprehensive list of effects on all neurotransmitters.

https://pharmrev.aspetjournals.org/content/73/1/202

List of the Psychedelic conferences for 2023. https://docs.google.com/spreadsheets/d/12rKvD_eNyYw-jWn9GW-PiBG8XrKo5tDYIp0dN7NI_Ek/edit#gid=0

The psychedelic ibogaine can treat addiction. The race is on to cash in | Drugs | The Guardian


illegal in the US, but in countries such as Costa Rica, Mexico, New Zealand and the Netherlands, it is unregulated, which has allowed clinics to flourish. Starting in the early 2000s, the opioid crisis – in April 2021, annual overdose deaths in the US reached 100000 for the first time; the Centers for Disease Control and Prevention estimates that nearly 76,000 of these deaths were from opioids – gave way to a booming industry of makeshift ibogaine treatment clinics like the one where Smith was treated, often set up in rented houses located right across the US border.



https://www.theguardian.com/society/2023/jan/23/ibogaine-iboga-drug-addiction-psychedelic-gabon

Yeah baby 😈

https://www.forbes.com/sites/chriswestfall/2023/01/26/buzzfeed-to-use-chatgpts-ai-for-content-creation-stock-up-200/?sh=28afc6aa7eae

Israeli find shown to combat antibiotic resistance by ‘pricking bacteria to death’ | The Times of Israel

Somewhere in the lab:

- Hey Yossi, Let's invent some smart approach, we just graduated from 8200?

- Nooaah, fuck it, Shlomo,let's do it old-school, what about physically destroy this shit 😈


"The substance contains “nano needles” which have a lethal effect on bacteria, and will be developed into topical creams and antibacterial coatings for surfaces, the scientists said, noting that it has shown 90% effectiveness in killing antibiotic-resistant bacteria in lab conditions."


https://www.timesofisrael.com/israeli-find-shown-to-combat-antibiotic-resistance-by-poking-bacteria-to-death/

It Looked Like A Nice Family Home. Cops Suspect It Was A Secret Drone Airport For MDMA Dropoffs

Cyberpunk future be like😋

https://www.forbes.com/sites/thomasbrewster/2023/01/17/drones-carry-mdma-into-america-via-niagara-falls/

Old, but interesting example what AI might "see" before death.

It might bring some thoughts on what people actually see before death or during death-like experience.




https://vimeo.com/340318187

Human Brain Organoids Respond to Visual Stimuli When Transplanted Into Adult Rats - Neuroscience News
We saw that a good number of neurons within the organoid responded to specific orientations of light, which gives us evidence that these organoid neurons were able to not just integrate with the visual system, but they were able to adopt very specific functions of the visual cortex.”


https://neurosciencenews.com/organoid-transplant-visual-stimuli-22436/

Australia to allow prenoscription of MDMA and psilocybin for treatment-resistant mental illnesses | Health | The Guardian

Woot!!! One more Country 🔥

"The drugs will only be allowed to be used in a very limited way, and remain otherwise prohibited, but the move was described as a “very welcome step away from what has been decades of demonisation”


https://www.theguardian.com/australia-news/2023/feb/03/australia-to-allow-prenoscription-of-mdma-and-psilocybin-for-treatment-resistant-mental-illnesses

MDMA and Psilocybin Are Approved as Medicines for the First Time | WIRED


Again, this is really important. Since I recently compared the release of ChatGPT and Proposition 122 in Colorado for decriminalization as A-ha moments. Now I'll tell you that Australia announcement for MDMA and Psylocybin approval in response to USA legalization efforts is like Google's investment in Anthropic ( OpenAI rival) in response to Microsoft deal with OpenAI happened yesterday.


Australia will likely impact whether other countries choose to offer the drugs for therapeutic purposes in the future—and that includes if it goes wrong and people get harmed. “I think the eyes of the world will be watching Australia now -


https://www.wired.com/story/australia-psilocybin-mdma-approval/