https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5saWJzeW4uY29tLzgxODk1L3Jzcw/episode/NjgxMmNkZTUtYThmZi00OWIxLThkMmMtZGU5NGM4MDQ2YjRl?ep=14
Why MDMA analogs?
1. Safer options for mory risky categories of people:
People with Cardiac deseas history
People over the age of 65
2. Other medical application apart form PTD
Social anxiety for Autism
Parkinson's desease
3. Other impoovements
Shorter therapy duration
More cheaper production
Skill level: #intermediate
Why MDMA analogs?
1. Safer options for mory risky categories of people:
People with Cardiac deseas history
People over the age of 65
2. Other medical application apart form PTD
Social anxiety for Autism
Parkinson's desease
3. Other impoovements
Shorter therapy duration
More cheaper production
Skill level: #intermediate
Google Podcasts
Psychedelics Today - PT410 – Nick Kadysh – Manufacturing MDMA and Why Creating MDMA Analogs Is So Important
In this episode, Joe interviews Nick Kadysh: Founder and CEO of PharmAla Biotech and member of the board of directors for The Canadian Psychedelic Businesses Association.
PharmAla Biotech is a Toronto-based Life Sciences company with two focuses: contracting…
PharmAla Biotech is a Toronto-based Life Sciences company with two focuses: contracting…
New Psychedelics compounds search.
Why?
Deal with First gen psychedelic issues:
- they were not created specifically to threat a particular disorder even if can do it with a certain efficacy
- they have cardiotoxicity related to 5ht2b mechanism
- long action duration length for therapy
New hopes and ideas:
- decouple halucenogetic from therapeutic effect
- potentially reaching even newer states of mind
- targetly engineered experience without so complex set and setting
What?
- Kanna alcaloids for premature ejaculation 😅
- BPL-003 for Treatment Resistant Depression (TRD).
- IHCH-7113 Non halucenogetic psychedelic for depression
- Ele-101 for depression and Alcohol Use Disorder (AUD).
How?
1. AI assisted search
- Predictive AI. Train on structure to properties (need big dataset of both)
- Generative AI. Evolutionary machines
2. Natural compounds search and enchantment
- Research existing less popular natural compounds rom indigenous communities
- Enchance properties (Increase a half life, change blood barrier penetration, etc..
3. Future approaches
- computational chemistry (compounds VS receptors )
- test on brain organoids
Skill level: #intermediate
https://youtu.be/BQoIozpBU5Y
Why?
Deal with First gen psychedelic issues:
- they were not created specifically to threat a particular disorder even if can do it with a certain efficacy
- they have cardiotoxicity related to 5ht2b mechanism
- long action duration length for therapy
New hopes and ideas:
- decouple halucenogetic from therapeutic effect
- potentially reaching even newer states of mind
- targetly engineered experience without so complex set and setting
What?
- Kanna alcaloids for premature ejaculation 😅
- BPL-003 for Treatment Resistant Depression (TRD).
- IHCH-7113 Non halucenogetic psychedelic for depression
- Ele-101 for depression and Alcohol Use Disorder (AUD).
How?
1. AI assisted search
- Predictive AI. Train on structure to properties (need big dataset of both)
- Generative AI. Evolutionary machines
2. Natural compounds search and enchantment
- Research existing less popular natural compounds rom indigenous communities
- Enchance properties (Increase a half life, change blood barrier penetration, etc..
3. Future approaches
- computational chemistry (compounds VS receptors )
- test on brain organoids
Skill level: #intermediate
https://youtu.be/BQoIozpBU5Y
YouTube
The Next Generation of Psychedelic Drugs
We all know about LSD, magic mushrooms, and MDMA. But what about BPL-003, IHCH-7113, and ELE-101? Since psychedelic drugs may soon become available for medicinal use, many companies have sought to develop original psychedelic compounds, which can then be…
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Don't waste your time looking at Starship launch. Check this. Q&A with first DMTX Psychenauts 💥
It promises to be a revolutionary moment in the history of psychedelic exploration. Like NASA ventures into space, Noonautics is embarking on a mission into the depths of the human psyche, navigating the alien landscape of the DMT experience.
Esteemed writer and researcher, Graham Hancock, will preside over the panel in collaboration with the renowned DMT expert, Dr. Andrew Gallimore. The panel will feature the brave explorers of Imperial College London’s recent groundbreaking Extended DMT research: Carl Hayden Smith, Jack Allocca, Alexander Beiner, and Anton Bilton, who will illuminate the audience with their personal narratives of traversing the extended DMT state.
Drawing parallels with the Search for Extraterrestrial Intelligence (SETI), the focus of the discourse will be on the profound encounters with DMT entities.
Just as SETI deciphers signals from distant stars, our panelists will unravel and interpret their experiences in the DMT realms, potentially reshaping our understanding of reality.
Skill level: #advanced
https://noonautics.org/etn/dmtx-panel/
It promises to be a revolutionary moment in the history of psychedelic exploration. Like NASA ventures into space, Noonautics is embarking on a mission into the depths of the human psyche, navigating the alien landscape of the DMT experience.
Esteemed writer and researcher, Graham Hancock, will preside over the panel in collaboration with the renowned DMT expert, Dr. Andrew Gallimore. The panel will feature the brave explorers of Imperial College London’s recent groundbreaking Extended DMT research: Carl Hayden Smith, Jack Allocca, Alexander Beiner, and Anton Bilton, who will illuminate the audience with their personal narratives of traversing the extended DMT state.
Drawing parallels with the Search for Extraterrestrial Intelligence (SETI), the focus of the discourse will be on the profound encounters with DMT entities.
Just as SETI deciphers signals from distant stars, our panelists will unravel and interpret their experiences in the DMT realms, potentially reshaping our understanding of reality.
Skill level: #advanced
https://noonautics.org/etn/dmtx-panel/
https://psychedelicspotlight.com/california-senate-votes-in-favor-of-legalizing-natural-psychedelics/
Woooooot, where is my US VISA😈???
Skill level: #fundamental
Woooooot, where is my US VISA😈???
Skill level: #fundamental
Psychedelic Spotlight
California Senate Votes in Favor of Legalizing Natural Psychedelics
The California psychedelics bill would legalize the personal use of certain amounts of psilocybin, psilocyn, DMT, ibogaine, and mescaline.
Scientists Gave People Psychedelics—and Then Erased Their Memory | WIRED
https://www.wired.com/story/psychedelics-study-design-research-rcts/
https://www.wired.com/story/psychedelics-study-design-research-rcts/
WIRED
Scientists Gave People Psychedelics—and Then Erased Their Memory
Psychedelics are hot, but flawed studies mean a lot of the health claims could be hype. To get better evidence, scientists are trying unusual methods.
Startups Have an Fun New Idea: Workplace Ketamine Sessions
What Da fuck😱
these alleged therapy sessions are pretty much exactly what they sound like: users lay down with cloth over their eyes, wait for a facilitator to inject a syringe of the psychedelic in their upper arms, and trip with their coworkers.
https://futurism.com/neoscope/startups-workplace-ketamine-sessions
What Da fuck😱
these alleged therapy sessions are pretty much exactly what they sound like: users lay down with cloth over their eyes, wait for a facilitator to inject a syringe of the psychedelic in their upper arms, and trip with their coworkers.
https://futurism.com/neoscope/startups-workplace-ketamine-sessions
NEOSCOPE
Startups Have a Fun New Idea: Workplace Ketamine Sessions
Office vibes a little off? Some startups say you should try group workplace ketamine sessions. File under: that's one way to do it.
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https://youtu.be/fcxjwA4C4Cw
Finally spent 2.5 hours listening this and haven't heard anything new for me except more details on application of psychedelic for fibromyalgia.
However, if you are relatively new to the field, who already watched some based Netflix movies but not ready to die into the deoths it's a good wrap up to bring you you from #fundamental to #novice skill level.
Skill level: #novice
Finally spent 2.5 hours listening this and haven't heard anything new for me except more details on application of psychedelic for fibromyalgia.
However, if you are relatively new to the field, who already watched some based Netflix movies but not ready to die into the deoths it's a good wrap up to bring you you from #fundamental to #novice skill level.
Skill level: #novice
YouTube
The Science of Psychedelics for Mental Health | Dr. Robin Carhart-Harris
In this episode, my guest is Robin Carhart-Harris, PhD, distinguished professor of neurology and psychiatry at the University of California, San Francisco. He is one of the leading researchers studying how psychedelics such as psilocybin, LSD and DMT can…
https://www.everydayhealth.com/integrative-health/psychedelic-therapy/guide/
Amazing wrap-up on current state of Psychedelics therapy. 👌👌👌
For those who enjoys reading more than listening.
Skill level : #Novice
Amazing wrap-up on current state of Psychedelics therapy. 👌👌👌
For those who enjoys reading more than listening.
Skill level : #Novice
Everyday Health
Psychedelic Therapy: A Complete Guide to Hallucinogen Use for Potential Improved Health
Medically Reviewed by Justin Laube, MD and Heidi Green, MD of American College of Lifestyle Medicine
https://medicalxpress.com/news/2023-06-mood-altering-mushroom-sales-bloom-safety.html
Skill level: #fundanental
Skill level: #fundanental
Medicalxpress
Mood-altering mushroom sales bloom despite safety concerns
When a hemp dispensary in this Florida city started to stock edibles with certain mushroom extracts last year, state regulators quickly ordered it to stop selling the items.
https://www.vice.com/en/article/3akkd9/psychedelic-cryptography-videos-have-hidden-messages-designed-to-be-seen-while-tripping?utm_source=reddit.com
Holy macaroni, that's amazing 🤯
A new competition focused on “Psychedelic Cryptography” has awarded cash prizes to artists who made videos encoded with hidden messages that can be most easily deciphered by a person who is tripping on psychedelic substances, such as LSD, ayahuasca, or psilocybin mushrooms.
Holy macaroni, that's amazing 🤯
Vice
These 'Psychedelic Cryptography' Videos Have Hidden Messages Designed to Be Seen While Tripping
The Qualia Research Institute has announced the winners to its "PsyCrypto" contest.
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Is the cosmos a giant neural network - Big Think
https://bigthink.com/hard-science/the-universe-may-be-a-giant-neural-network-heres-why/
https://bigthink.com/hard-science/the-universe-may-be-a-giant-neural-network-heres-why/
Big Think
The case for why our Universe may be a giant neural network
Neuroscientist and author Bobby Azarian explores the idea that the Universe is a self-organizing system that evolves and learns.
Psychedelics startup Nue Life Health rolls out free version of its ketamine therapy tracking app | TechCrunch
https://techcrunch.com/2023/06/15/psychedelics-startup-nue-life-health-rolls-out-free-version-of-its-ketamine-therapy-tracking-app/
https://techcrunch.com/2023/06/15/psychedelics-startup-nue-life-health-rolls-out-free-version-of-its-ketamine-therapy-tracking-app/
TechCrunch
Psychedelics startup Nue Life Health rolls out free version of its ketamine therapy tracking app | TechCrunch
Nue Life Health is a U.S.-based telemedicine startup that combines psychedelic-assisted therapies and a health tracking app. Previously, the app was only
Psychedelics Unlock Learning Windows in the Brain - Neuroscience News
I've experienced that "window" and recently explored a possible ways of applying it to language learning and even tried one experiment.
Excited to hear that it's now proven scientifically and hope to continue experiments 😁
Psychedelic drugs, including ibogaine, ketamine, LSD, MDMA, and psilocybin, can reopen the “critical periods” of brain development in mice, making them more receptive to learning from their environment.
The length of these reopened critical periods varies depending on the psychedelic drug used, ranging from 48 hours with ketamine to four weeks with ibogaine.
The study also identified molecular mechanisms influenced by psychedelics, including 65 protein-producing genes that show expression differences during and after the critical period.
https://neurosciencenews.com/psychedelics-social-learning-23466/
I've experienced that "window" and recently explored a possible ways of applying it to language learning and even tried one experiment.
Excited to hear that it's now proven scientifically and hope to continue experiments 😁
Psychedelic drugs, including ibogaine, ketamine, LSD, MDMA, and psilocybin, can reopen the “critical periods” of brain development in mice, making them more receptive to learning from their environment.
The length of these reopened critical periods varies depending on the psychedelic drug used, ranging from 48 hours with ketamine to four weeks with ibogaine.
The study also identified molecular mechanisms influenced by psychedelics, including 65 protein-producing genes that show expression differences during and after the critical period.
https://neurosciencenews.com/psychedelics-social-learning-23466/
Neuroscience News
Psychedelics Unlock Learning Windows in the Brain
Researchers discovered a unique property of psychedelic drugs: their ability to reopen "critical periods" in the brain, times when the brain is highly susceptible to environmental learning signals.
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