CK, Creatine kinase┇Wed.150317┇
================
♦️CK as it is now called (formerly referred to as creatinine phosphokinase,CPK), is very important in energy utilization and is involved in the reaction that changes creatine to creatinine for ATP production.
شاهد الفيديو 👇👇
https://news.1rj.ru/str/Biochem_Lab/122
♦️CK can be measured as one total enzyme in the serum. If the CK total is above normal, measurement of CK-MB is needed..
♦️Isoenzymes:
==========
🔻CK-I (BB): produced primarily by brain tissue and smooth muscle.
🔻CK-II (MB): produced primarily by heart tissue.
🔻CK-III (MM): produced primarily by muscle tissue.
(Total CK)🆚(CK-MB):
♦️Since CK is widely distributed in tissues, elevations in total serum CK lack specificity for cardiac damage. The normal range of total CK also varies considerably; a twofold or greater increase in the CK concentration is required for diagnosis. This criterion can be problematic in older individuals who, because of their lower muscle mass, may have low baseline serum total CK and, during MI, may have elevated serum CK-MB with values of total CK that rise but remain within the normal range. For these reasons, total CK has not been used in the diagnosis of myocardial damage for years.
♦️Clinical interpretation
=================
-The CK-MB isoform of creatine kinase is expressed in heart muscle. It resides in the cytosol and facilitates movement of high energy phosphates into and out of mitochondria. Since it has a short duration, it cannot be used for late diagnosis of acute MI, but it is more useful than the troponins to detect a reinfarction as troponins remain in the bloodstream for 5 days or longer after the initial infarction.
🔻CK, the frst enzyme to be elevated after a myocardial infarction, begins to rise in 3–6 hours and may peak in the frst 24 hours. The timing of the drawing for the CK is crucial because the enzyme may disappear from the bloodstream in less than 24 hours after a myocardial infarction. In some clients, the CK returns to normal within 16 hours after the chest pain.
- It is relatively specific when skeletal muscle damage is not present.
https://telegram.me/joinchat/AAAAAECuqoTkgQkHpiHlGA
================
♦️CK as it is now called (formerly referred to as creatinine phosphokinase,CPK), is very important in energy utilization and is involved in the reaction that changes creatine to creatinine for ATP production.
شاهد الفيديو 👇👇
https://news.1rj.ru/str/Biochem_Lab/122
♦️CK can be measured as one total enzyme in the serum. If the CK total is above normal, measurement of CK-MB is needed..
♦️Isoenzymes:
==========
🔻CK-I (BB): produced primarily by brain tissue and smooth muscle.
🔻CK-II (MB): produced primarily by heart tissue.
🔻CK-III (MM): produced primarily by muscle tissue.
(Total CK)🆚(CK-MB):
♦️Since CK is widely distributed in tissues, elevations in total serum CK lack specificity for cardiac damage. The normal range of total CK also varies considerably; a twofold or greater increase in the CK concentration is required for diagnosis. This criterion can be problematic in older individuals who, because of their lower muscle mass, may have low baseline serum total CK and, during MI, may have elevated serum CK-MB with values of total CK that rise but remain within the normal range. For these reasons, total CK has not been used in the diagnosis of myocardial damage for years.
♦️Clinical interpretation
=================
-The CK-MB isoform of creatine kinase is expressed in heart muscle. It resides in the cytosol and facilitates movement of high energy phosphates into and out of mitochondria. Since it has a short duration, it cannot be used for late diagnosis of acute MI, but it is more useful than the troponins to detect a reinfarction as troponins remain in the bloodstream for 5 days or longer after the initial infarction.
🔻CK, the frst enzyme to be elevated after a myocardial infarction, begins to rise in 3–6 hours and may peak in the frst 24 hours. The timing of the drawing for the CK is crucial because the enzyme may disappear from the bloodstream in less than 24 hours after a myocardial infarction. In some clients, the CK returns to normal within 16 hours after the chest pain.
- It is relatively specific when skeletal muscle damage is not present.
https://telegram.me/joinchat/AAAAAECuqoTkgQkHpiHlGA
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Clinical 🅱iochemistry
How does creatine work?!
=====================
Creatine is changed into a molecule called phosphocreatine which serves as a storage reservoir for regenerating ATP.
=====================
Creatine is changed into a molecule called phosphocreatine which serves as a storage reservoir for regenerating ATP.
✨🍃🍂🌺🍃🍂🌺🍃🍂🌺
🍃🍂🌺🍃🍂🌺┇Fri.170317┇
🍂🌺🍂 Cardiac Troponin
===================
🔰The most sensitive and specific test for myocardial damage. Because it has increased specificity compared with CK-MB, troponin is a superior marker for myocardial injury. Troponin is released during MI from the☞cytosolic pool of the myocytes. Its subsequent release is prolonged with☞degradation of actin and myosin filaments . Isoforms of the protein, T and I, are specific to myocardium.
🔰Clinical interpretation
==================
The initial rise in cardiac troponins ( cTnI and cTnT) after myocardial infarction occurs at about the same time as CK and CK–MB (4 to 8 hours), but this rise continues for longer time (days to weeks) after AMI.
【 التربونين يوجد في سيتوبلازم الخلايا القلبية على شكل بروتين حر، والغالب مرتبط بالياف العضلة ، لذا فهو يرتفع تدريجيا بعد الاحتشاء القلبي بسبب خروج التروبونين الحر ويصل الى ارتفاع عالي ، ثم يبدأ بالهبوط بعد 24 ساعة ولكنه يظل فوق المستوى الطبيعي ، ثم يرتفع مرة اخرى اعلى من الارتفاغ الاول بسبب انطلاق التروبونين المرتبط بالالياف】.
@Biochem_Lab
🔰Troponin is a complex of three protein subunits:
شاهد الفيديو👇👇في الاسفل..
1⃣Troponin C(calcium-binding subunit (TnC, 18 kDa)..
2⃣Troponin I(inhibitory subunit,TnI, 24 kDa),.
3⃣Troponin T(tropomyosin-binding subunit,TnT, 37 kDa),).
🔸TnC, the forms found in type 2 fibers and cardiac muscle are identical, obviating its use as a differential marker.
🔸TnI has a cardiospecific form (cTnI). The presence of the cardiospecific form in tissue other than cardiac muscle has never been documented.
🔸TnT has been detected in fetal skeletal muscle and diseased skeletal muscle. However, post-translational modifications cause detectable differences between cTnT produced in myocardium and cTnT produced in diseased skeletal muscle. Hence an immunochemical test should have myocardial specificity approaching 100% specificity. Nevertheless, small increases in circulating cTnT, even with newer assays, have been reported in patients with muscular dystrophy and renal failure who have no other evidence of cardiac disease.
https://telegram.me/joinchat/AAAAAECuqoTkgQkHpiHlGA
🌺 @Biochem_Lab
🍂🌺🍂
🍃🍂🌺🍃🍂🌺
✨🍃🍂🌺🍃🍂🌺🍃🍂🌺
🍃🍂🌺🍃🍂🌺┇Fri.170317┇
🍂🌺🍂 Cardiac Troponin
===================
🔰The most sensitive and specific test for myocardial damage. Because it has increased specificity compared with CK-MB, troponin is a superior marker for myocardial injury. Troponin is released during MI from the☞cytosolic pool of the myocytes. Its subsequent release is prolonged with☞degradation of actin and myosin filaments . Isoforms of the protein, T and I, are specific to myocardium.
🔰Clinical interpretation
==================
The initial rise in cardiac troponins ( cTnI and cTnT) after myocardial infarction occurs at about the same time as CK and CK–MB (4 to 8 hours), but this rise continues for longer time (days to weeks) after AMI.
【 التربونين يوجد في سيتوبلازم الخلايا القلبية على شكل بروتين حر، والغالب مرتبط بالياف العضلة ، لذا فهو يرتفع تدريجيا بعد الاحتشاء القلبي بسبب خروج التروبونين الحر ويصل الى ارتفاع عالي ، ثم يبدأ بالهبوط بعد 24 ساعة ولكنه يظل فوق المستوى الطبيعي ، ثم يرتفع مرة اخرى اعلى من الارتفاغ الاول بسبب انطلاق التروبونين المرتبط بالالياف】.
@Biochem_Lab
🔰Troponin is a complex of three protein subunits:
شاهد الفيديو👇👇في الاسفل..
1⃣Troponin C(calcium-binding subunit (TnC, 18 kDa)..
2⃣Troponin I(inhibitory subunit,TnI, 24 kDa),.
3⃣Troponin T(tropomyosin-binding subunit,TnT, 37 kDa),).
🔸TnC, the forms found in type 2 fibers and cardiac muscle are identical, obviating its use as a differential marker.
🔸TnI has a cardiospecific form (cTnI). The presence of the cardiospecific form in tissue other than cardiac muscle has never been documented.
🔸TnT has been detected in fetal skeletal muscle and diseased skeletal muscle. However, post-translational modifications cause detectable differences between cTnT produced in myocardium and cTnT produced in diseased skeletal muscle. Hence an immunochemical test should have myocardial specificity approaching 100% specificity. Nevertheless, small increases in circulating cTnT, even with newer assays, have been reported in patients with muscular dystrophy and renal failure who have no other evidence of cardiac disease.
https://telegram.me/joinchat/AAAAAECuqoTkgQkHpiHlGA
🌺 @Biochem_Lab
🍂🌺🍂
🍃🍂🌺🍃🍂🌺
✨🍃🍂🌺🍃🍂🌺🍃🍂🌺
Forwarded from Deleted Account
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Troponin role in muscle contraction
Forwarded from الطب المختبري
62- من الاخطاء الايجابية التي تؤثرعلى الفحوصات في عينة السيرم￤
➢Lipemic
➢Old serum
➢Contaminated serum
والاخطاء السلبية￤
➢Antibiotic therapy
➢Hemolysed sample
💟 #خواطر_مخبرية
🕳قناة↜ @LabMed2016
🕳بوت↜ @Lab_Med_ALMAS_bot
➢Lipemic
➢Old serum
➢Contaminated serum
والاخطاء السلبية￤
➢Antibiotic therapy
➢Hemolysed sample
💟 #خواطر_مخبرية
🕳قناة↜ @LabMed2016
🕳بوت↜ @Lab_Med_ALMAS_bot
Forwarded from الطب المختبري
64- أفضـل Dilution مستخدم لتخفيف العينات الدهنية ،او التي تجاوزت Linearty
هو بنسبة 1 : 10【100ميكرونSample + ميكرون900 R. dilution】 والناتج يضرب 10x
💟 #خواطر_مخبرية
🕳قناة↜ @LabMed2016
🕳بوت↜ @Lab_Med_ALMAS_bot
هو بنسبة 1 : 10【100ميكرونSample + ميكرون900 R. dilution】 والناتج يضرب 10x
💟 #خواطر_مخبرية
🕳قناة↜ @LabMed2016
🕳بوت↜ @Lab_Med_ALMAS_bot
Do you receive a green serum during working in the lab !!!
See the causes in the picture👆
@Biochem_Lab
See the causes in the picture👆
@Biochem_Lab
التغيرات التي تحصل لعينة اليورن اذا تركت لاكثر من ساعتين في درجة حرارة الغرفة .
┏━━━━⚗━━━┓
☞ @Biochem_Lab ☜
┗━━━💉━━━━┛
┏━━━━⚗━━━┓
☞ @Biochem_Lab ☜
┗━━━💉━━━━┛
التشابة والاختلاف بين نسب المواد الموجودة في الـ Plasma والـ Urine
http://bit.ly/2mpJ0Y9
http://bit.ly/2mpJ0Y9
Electrolytes - name, values, why wee need them, and where they are found.
الالكتروليت وانواعها والنسب الطبيعية ،
ولماذا نحتاج تحليل كل نوع واين نجدها 🌱🍃🌾🌿🌱
http://bit.ly/2mpJ0Y9
الالكتروليت وانواعها والنسب الطبيعية ،
ولماذا نحتاج تحليل كل نوع واين نجدها 🌱🍃🌾🌿🌱
http://bit.ly/2mpJ0Y9
Glomerular Syndromes – Nephrotic vs Nephritic syndrome
The difference between Nephrotic & Nephritic syndrome is something easy to forget, just remember that Nephrotic syndrome involves the loss of a lot of protein, whereas Nephritic syndrome involves the loss of a lot of blood.
http://bit.ly/2mpJ0Y9
The difference between Nephrotic & Nephritic syndrome is something easy to forget, just remember that Nephrotic syndrome involves the loss of a lot of protein, whereas Nephritic syndrome involves the loss of a lot of blood.
http://bit.ly/2mpJ0Y9
Forwarded from اتچ بات
Forwarded from اتچ بات