✨🍃🍂🌺🍃🍂🌺🍃🍂🌺
🍃🍂🌺🍃🍂🌺┇Fri.170317┇
🍂🌺🍂 Cardiac Troponin
===================
🔰The most sensitive and specific test for myocardial damage. Because it has increased specificity compared with CK-MB, troponin is a superior marker for myocardial injury. Troponin is released during MI from the☞cytosolic pool of the myocytes. Its subsequent release is prolonged with☞degradation of actin and myosin filaments . Isoforms of the protein, T and I, are specific to myocardium.
🔰Clinical interpretation
==================
The initial rise in cardiac troponins ( cTnI and cTnT) after myocardial infarction occurs at about the same time as CK and CK–MB (4 to 8 hours), but this rise continues for longer time (days to weeks) after AMI.
【 التربونين يوجد في سيتوبلازم الخلايا القلبية على شكل بروتين حر، والغالب مرتبط بالياف العضلة ، لذا فهو يرتفع تدريجيا بعد الاحتشاء القلبي بسبب خروج التروبونين الحر ويصل الى ارتفاع عالي ، ثم يبدأ بالهبوط بعد 24 ساعة ولكنه يظل فوق المستوى الطبيعي ، ثم يرتفع مرة اخرى اعلى من الارتفاغ الاول بسبب انطلاق التروبونين المرتبط بالالياف】.
@Biochem_Lab
🔰Troponin is a complex of three protein subunits:
شاهد الفيديو👇👇في الاسفل..
1⃣Troponin C(calcium-binding subunit (TnC, 18 kDa)..
2⃣Troponin I(inhibitory subunit,TnI, 24 kDa),.
3⃣Troponin T(tropomyosin-binding subunit,TnT, 37 kDa),).
🔸TnC, the forms found in type 2 fibers and cardiac muscle are identical, obviating its use as a differential marker.
🔸TnI has a cardiospecific form (cTnI). The presence of the cardiospecific form in tissue other than cardiac muscle has never been documented.
🔸TnT has been detected in fetal skeletal muscle and diseased skeletal muscle. However, post-translational modifications cause detectable differences between cTnT produced in myocardium and cTnT produced in diseased skeletal muscle. Hence an immunochemical test should have myocardial specificity approaching 100% specificity. Nevertheless, small increases in circulating cTnT, even with newer assays, have been reported in patients with muscular dystrophy and renal failure who have no other evidence of cardiac disease.
https://telegram.me/joinchat/AAAAAECuqoTkgQkHpiHlGA
🌺 @Biochem_Lab
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✨🍃🍂🌺🍃🍂🌺🍃🍂🌺
🍃🍂🌺🍃🍂🌺┇Fri.170317┇
🍂🌺🍂 Cardiac Troponin
===================
🔰The most sensitive and specific test for myocardial damage. Because it has increased specificity compared with CK-MB, troponin is a superior marker for myocardial injury. Troponin is released during MI from the☞cytosolic pool of the myocytes. Its subsequent release is prolonged with☞degradation of actin and myosin filaments . Isoforms of the protein, T and I, are specific to myocardium.
🔰Clinical interpretation
==================
The initial rise in cardiac troponins ( cTnI and cTnT) after myocardial infarction occurs at about the same time as CK and CK–MB (4 to 8 hours), but this rise continues for longer time (days to weeks) after AMI.
【 التربونين يوجد في سيتوبلازم الخلايا القلبية على شكل بروتين حر، والغالب مرتبط بالياف العضلة ، لذا فهو يرتفع تدريجيا بعد الاحتشاء القلبي بسبب خروج التروبونين الحر ويصل الى ارتفاع عالي ، ثم يبدأ بالهبوط بعد 24 ساعة ولكنه يظل فوق المستوى الطبيعي ، ثم يرتفع مرة اخرى اعلى من الارتفاغ الاول بسبب انطلاق التروبونين المرتبط بالالياف】.
@Biochem_Lab
🔰Troponin is a complex of three protein subunits:
شاهد الفيديو👇👇في الاسفل..
1⃣Troponin C(calcium-binding subunit (TnC, 18 kDa)..
2⃣Troponin I(inhibitory subunit,TnI, 24 kDa),.
3⃣Troponin T(tropomyosin-binding subunit,TnT, 37 kDa),).
🔸TnC, the forms found in type 2 fibers and cardiac muscle are identical, obviating its use as a differential marker.
🔸TnI has a cardiospecific form (cTnI). The presence of the cardiospecific form in tissue other than cardiac muscle has never been documented.
🔸TnT has been detected in fetal skeletal muscle and diseased skeletal muscle. However, post-translational modifications cause detectable differences between cTnT produced in myocardium and cTnT produced in diseased skeletal muscle. Hence an immunochemical test should have myocardial specificity approaching 100% specificity. Nevertheless, small increases in circulating cTnT, even with newer assays, have been reported in patients with muscular dystrophy and renal failure who have no other evidence of cardiac disease.
https://telegram.me/joinchat/AAAAAECuqoTkgQkHpiHlGA
🌺 @Biochem_Lab
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Forwarded from Deleted Account
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Troponin role in muscle contraction
Forwarded from الطب المختبري
62- من الاخطاء الايجابية التي تؤثرعلى الفحوصات في عينة السيرم￤
➢Lipemic
➢Old serum
➢Contaminated serum
والاخطاء السلبية￤
➢Antibiotic therapy
➢Hemolysed sample
💟 #خواطر_مخبرية
🕳قناة↜ @LabMed2016
🕳بوت↜ @Lab_Med_ALMAS_bot
➢Lipemic
➢Old serum
➢Contaminated serum
والاخطاء السلبية￤
➢Antibiotic therapy
➢Hemolysed sample
💟 #خواطر_مخبرية
🕳قناة↜ @LabMed2016
🕳بوت↜ @Lab_Med_ALMAS_bot
Forwarded from الطب المختبري
64- أفضـل Dilution مستخدم لتخفيف العينات الدهنية ،او التي تجاوزت Linearty
هو بنسبة 1 : 10【100ميكرونSample + ميكرون900 R. dilution】 والناتج يضرب 10x
💟 #خواطر_مخبرية
🕳قناة↜ @LabMed2016
🕳بوت↜ @Lab_Med_ALMAS_bot
هو بنسبة 1 : 10【100ميكرونSample + ميكرون900 R. dilution】 والناتج يضرب 10x
💟 #خواطر_مخبرية
🕳قناة↜ @LabMed2016
🕳بوت↜ @Lab_Med_ALMAS_bot
Do you receive a green serum during working in the lab !!!
See the causes in the picture👆
@Biochem_Lab
See the causes in the picture👆
@Biochem_Lab
التغيرات التي تحصل لعينة اليورن اذا تركت لاكثر من ساعتين في درجة حرارة الغرفة .
┏━━━━⚗━━━┓
☞ @Biochem_Lab ☜
┗━━━💉━━━━┛
┏━━━━⚗━━━┓
☞ @Biochem_Lab ☜
┗━━━💉━━━━┛
التشابة والاختلاف بين نسب المواد الموجودة في الـ Plasma والـ Urine
http://bit.ly/2mpJ0Y9
http://bit.ly/2mpJ0Y9
Electrolytes - name, values, why wee need them, and where they are found.
الالكتروليت وانواعها والنسب الطبيعية ،
ولماذا نحتاج تحليل كل نوع واين نجدها 🌱🍃🌾🌿🌱
http://bit.ly/2mpJ0Y9
الالكتروليت وانواعها والنسب الطبيعية ،
ولماذا نحتاج تحليل كل نوع واين نجدها 🌱🍃🌾🌿🌱
http://bit.ly/2mpJ0Y9
Glomerular Syndromes – Nephrotic vs Nephritic syndrome
The difference between Nephrotic & Nephritic syndrome is something easy to forget, just remember that Nephrotic syndrome involves the loss of a lot of protein, whereas Nephritic syndrome involves the loss of a lot of blood.
http://bit.ly/2mpJ0Y9
The difference between Nephrotic & Nephritic syndrome is something easy to forget, just remember that Nephrotic syndrome involves the loss of a lot of protein, whereas Nephritic syndrome involves the loss of a lot of blood.
http://bit.ly/2mpJ0Y9
Forwarded from اتچ بات
Forwarded from اتچ بات