Clinic and Laboratory Integration Program

✅The Cancer Research Institute funds research aimed at furthering the development of immunological approaches to the diagnosis, treatment, and prevention of cancer. The Institute's mission is to bring effective immune system-based therapies to cancer patients sooner.

✅The Clinic and Laboratory Integration Program (CLIP) grants provide catalytic support for translational laboratory studies designed to answer new specific scientific questions that arise in the clinic, with special focus on improving immunotherapy for cancer patients.

✅CLIP grants provide up to $200,000 over a two-year period.

✅For more information:
http://www.cancerresearch.org/scientists/fellowships-grants/translational-research-grants/clip-application-guidelines

#Grant

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iATLAS
CRI Awards Grant to Develop Powerful Genomic Data Resource for Cancer Immunotherapy Researchers

✅The CRI iAtlas database is the first comprehensive effort in immuno-oncology to address the recent National Cancer Moonshot Blue Ribbon Panel recommendation to establish a pan-cancer immune atlas that would help catalyze new research in cancer immunotherapy.

✅The CRI iAtlas will serve as a central knowledge base to capture data on the tumor microenvironment and its impact on anti-cancer immune responses. Data generated by the working group, which includes molecular profiling of over 10,000 tumors across 33 tumor types as well as a series of results on immune-tumor interaction and response mechanisms, will provide rich characterizations of the relationship between tumors and the immune microenvironment and its impact on patient outcomes:
https://www.cri-iatlas.org

✅For more information:
http://cancerresearch.org/news/2017/cri-awards-grant-to-develop-powerful-genomic-data

#Grant

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Comparison of the effects of adipose tissue mesenchymal stromal cell-derived exosomes with conditioned media on neutrophil function and apoptosis

New paper by USERN interest groups

🌀Mesenchymal stromal cells (MSCs)-derived exosomes and conditioned media (CM) increased neutrophil phagocytosis capacity.

🌀The MSC-CM augmented neutrophil reactive oxygen species (ROS) production, but it couldn’t decrease neutrophil apoptosis.

🌀MSC-xosomes could decrease neutrophil apoptosis.

🌀MSC-exosomes and CM may be useful for increasing immunity by improving neutrophil function and survival.

To read the full paper:
https://www.sciencedirect.com/science/article/pii/S1567576919306964?via%3Dihub

#Paper

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IL-17 and colorectal cancer: From carcinogenesis to treatment

New paper by USERN interest groups

🌀Interleukin-17 can promote colorectal cancer tumorigenesis by several pathways.

🌀Interleukin-17 is associated with metastasis and poor prognosis in colorectal cancer.

🌀Interleukin-17 is a protective cytokineagainst colorectal cancer.

🌀Interleukin-17 can be used as a diagnostic marker in colorectal cancer.

🌀Interleukin-17 has been a new target in treatment of colorectal cancer patients.

To read the full paper:
https://www.sciencedirect.com/science/article/abs/pii/S1043466619300092?via%3Dihub

#Paper

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USERN RESEARCH WEEK

🔹USERN SUMMER EVENT
🔹August 2019
🔹For more information and register:
https://docs.google.com/forms/d/e/1FAIpQLSfRTbSIU15Lb9tkyPSacghOW_85EiWj0UHiU-sYeyfxHdzy7w/viewform

#Workshop

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Post-doctoral position in Immunotherapy
The University of Houston

✅Postdoctoral position to investigate T-cell based therapies in collaboration with M.D. Anderson Cancer Center, funded by the CPRIT/DoD/NSF. The candidate needs to have prior documented experience in molecular biology and in working with immune cells. The successful candidate will work on a multi-disciplinary team involving engineers and clinicians.

✅ Education/Experience: A Ph.D. or MD/Ph.D. degree in a related field like molecular or cell biology is required. Experience with standard immunological assays like ELISA/ELISpot/Flow-cytometry is an advantage. Experience with viral transduction of immune cells is an advantage.

✅Please send CV and list of three references via email to nvaradarajan@uh.edu

#Postdoc_position

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Killer T Cell and Cancer Cell

Source: https://youtu.be/ntk8XsxVDi0

#Movie

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Tumour Immunology and Immunotherapy

Source: https://youtu.be/K09xzIQ8zsg
Nature Reviews Cancer and Nature Reviews Immunology

#Movie

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How does cancer immunotherapy work?

Source: https://youtu.be/CwaMZCu4kpI
MD Anderson Cancer Center

#Movie

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Immunology Wars: Monoclonal Antibodies

Source: https://youtu.be/5AXApBbj1ps
Nature Video

#Movie

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Tumor-Related Immune Checkpoints and The Development of Targeted Cancer Immunotherapies

Source: https://youtu.be/Nb3b5XfMgIM
OriGene

#Movie

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🏅 چهارمین کنگره بین المللی یوسرن و جشنواره جایزه یوسرن
۱۷ تا ۱۹ آبان ماه ۱۳۹۸
بوداپست، مجارستان

با افتخار به اطلاع میرساند که امسال بیش از ۱۰۰۰۰ دانشمند جوان نامزد شرکت در رقابت بین المللی جایزه یوسرن شدند، که از این میان بیش از ۲۰۰ کاندید نهایی در ۵ حیطه اصلی (علوم ریاضی، علوم فیزیکی و شیمی، علوم بیولوژی، علوم پزشکی و علوم اجتماعی) به دبیرخانه جشنواره ارسال شدند.
از این بین پس از داوری توسط بورد مشاورین، ۱۰ نامزد منتخب در هر حیطه معرفی شده اند.

سپاسگزار همراهیتان خواهیم بود اگر دقایقی از وقت خود را در اختیارمان قرار داده و از نگاه خود، به این نامزد ها امتیاز دهید 🙏

لینک فرم ثبت آرا:
http://shorturl.at/cnvW3

📌جهت آشنایی بیشتر با کنگره یوسرن:
https://userncongress.com/

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Memorial Sloan Kettering Cancer Center
Postdoctoral Fellow Adusumilli Lab

✅Memorial Sloan Kettering Cancer Center (MSK) is one of the world’s leading cancer centers. The blending of research with patient care is at the heart of everything they do.

✅They currently have a postdoctoral position available in the Adusumilli Laboratory at MSK:
https://www.mskcc.org/research-areas/labs/prasad-adusumilli
The laboratory’s focus is on developing and translating adoptive T-cell therapy for the treatment of cancers.

✅The ideal candidate will have a PhD or MD/PhD, with a background in immunology, a passion for science, and a desire to advance the understanding and treatment of cancer. 

✅Please send a CV, bibliography, brief statement of research interests, and names and details of three references to:
Krishna Tobon
Grants Coordinator/Editor
tobonk@mskcc.org

#Postdoc_position

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Cancer Immunology and Immunotherapy

🎤Interview with James P. Allison
🏅Nobel Laureate 2018

#Interview
#Nobel

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✒️Write a scientific paper like a pro...

▶️Once per year!
▶️The first and the last Research week of this year!
▶️USERN Research Week
▶️USERN Summer Event
▶️August 24-29, 2019

✔️For more information and registration:
https://docs.google.com/forms/d/e/1FAIpQLSfRTbSIU15Lb9tkyPSacghOW_85EiWj0UHiU-sYeyfxHdzy7w/viewform

#Research

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Natural Killer Cells and Cancer Therapy, What We Know and Where We Are Going

💠New Paper by CIP

Natural killer (NK) cells are among the significant components of innate immune system and they have come to the first line of defense against tumor cells developing inside the body. CD56lo/CD16+ NK cells are highly cytotoxic and CD56hi NK cells can produce cytokines and perform a regulatory function. Specific features of NK cells have made them a unique choice for cancer immunotherapy. Simple interventions like cytokine-injection to boost the internal NK cells were the first trials to target these cells. Nowadays, many other types of intervention are under investigation, such as adoptive NK cell immunotherapy. In this paper, we will discuss the biology and function of NK cells in cancer immunosurveillance and therapeutic approaches against cancer via using NK cells.

https://www.futuremedicine.com/doi/full/10.2217/imt-2019-0040

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Nanoparticle-siRNA: a potential strategy for ovarian cancer therapy?

🌀New paper by CIP

Ovarian cancer is one of the most common causes of mortality throughout the world. Unfortunately, chemotherapy has failed to cure advanced cancers developing multidrug resistance (MDR). Moreover, it has critical side effects because of nonspecific toxicity. Thanks to specific silencing of oncogenes and MDR-associated genes, nano-siRNA drugs can be a great help address the limitations of chemotherapy. Here, we review the current advances in nanoparticle-mediated siRNA delivery strategies such as polymeric- and lipid-based systems, rigid nanoparticles and nanoparticles coupled to specific ligand systems. Nanoparticle-based codelivery of anticancer drugs and siRNA targeting various mechanisms of MDR is a cutting-edge strategy for ovarian cancer therapy, which is completely discussed in this review.


🌀https://www.futuremedicine.com/doi/full/10.2217/nnm-2018-0379

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🌏یوسرن و علم بدون مرز

⁉️چگونه علم بدون مرز به نفع همه ماست؟

سخنرانی تدکس دکتر نیما رضایی موسس و ریاست یوسرن در تدکس تهران 2019

مشاهده از طریق یوتیوب:
https://youtu.be/TtnEZUN8-bQ

مشاهده از طریق آپارات:
https://www.aparat.com/v/ICp1Y

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Nanoparticle-siRNA: a potential strategy for ovarian cancer therapy?

New paper by USERN interest groups

🌀Ovarian cancer is one of the most common causes of mortality throughout the world.

🌀Thanks to specific silencing of oncogenes and MDR-associated genes, nano-siRNA drugs can be a great help address the limitations of chemotherapy.

🌀Here, we review the current advances in nanoparticle-mediated siRNA delivery strategies such as polymeric- and lipid-based systems, rigid nanoparticles and nanoparticles coupled to specific ligand systems.

🌀Nanoparticle-based codelivery of anticancer drugs and siRNA targeting various mechanisms of MDR is a cutting-edge strategy for ovarian cancer.

To read the full paper:
https://www.futuremedicine.com/doi/abs/10.2217/nnm-2018-0379?rfr_dat=cr_pub%3Dpubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&journalCode=nnm

#Paper

@niima_usern
@cip_usern
@usern_net

Natural killer cells and cancer therapy, what we know and where we are going

New paper by USERN interest groups

🌀Natural killer (NK) cells are among the significant components of innate immune system and they have come to the first line of defense against tumor cells developing inside the body. CD56lo/CD16+ NK cells are highly cytotoxic and CD56hi NK cells can produce cytokines and perform a regulatory function.

🌀Specific features of NK cells have made them a unique choice for cancer immunotherapy.

🌀Simple interventions like cytokine-injection to boost the internal NK cells were the first trials to target these cells. Nowadays, many other types of intervention are under investigation, such as adoptive NK cell immunotherapy.

🌀Here,the biology and function of NK cells in cancer immunosurveillance and therapeutic approaches against cancer via using NK cells are discussed.

To read the full paper:
https://www.futuremedicine.com/doi/full/10.2217/imt-2019-0040

#Paper

@niima_usern
@cip_usern
@usern_net