USERN RESEARCH WEEK

🔹USERN SUMMER EVENT
🔹August 2019
🔹For more information and register:
https://docs.google.com/forms/d/e/1FAIpQLSfRTbSIU15Lb9tkyPSacghOW_85EiWj0UHiU-sYeyfxHdzy7w/viewform

#Workshop

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Post-doctoral position in Immunotherapy
The University of Houston

✅Postdoctoral position to investigate T-cell based therapies in collaboration with M.D. Anderson Cancer Center, funded by the CPRIT/DoD/NSF. The candidate needs to have prior documented experience in molecular biology and in working with immune cells. The successful candidate will work on a multi-disciplinary team involving engineers and clinicians.

✅ Education/Experience: A Ph.D. or MD/Ph.D. degree in a related field like molecular or cell biology is required. Experience with standard immunological assays like ELISA/ELISpot/Flow-cytometry is an advantage. Experience with viral transduction of immune cells is an advantage.

✅Please send CV and list of three references via email to nvaradarajan@uh.edu

#Postdoc_position

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Killer T Cell and Cancer Cell

Source: https://youtu.be/ntk8XsxVDi0

#Movie

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Tumour Immunology and Immunotherapy

Source: https://youtu.be/K09xzIQ8zsg
Nature Reviews Cancer and Nature Reviews Immunology

#Movie

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How does cancer immunotherapy work?

Source: https://youtu.be/CwaMZCu4kpI
MD Anderson Cancer Center

#Movie

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Immunology Wars: Monoclonal Antibodies

Source: https://youtu.be/5AXApBbj1ps
Nature Video

#Movie

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Tumor-Related Immune Checkpoints and The Development of Targeted Cancer Immunotherapies

Source: https://youtu.be/Nb3b5XfMgIM
OriGene

#Movie

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🏅 چهارمین کنگره بین المللی یوسرن و جشنواره جایزه یوسرن
۱۷ تا ۱۹ آبان ماه ۱۳۹۸
بوداپست، مجارستان

با افتخار به اطلاع میرساند که امسال بیش از ۱۰۰۰۰ دانشمند جوان نامزد شرکت در رقابت بین المللی جایزه یوسرن شدند، که از این میان بیش از ۲۰۰ کاندید نهایی در ۵ حیطه اصلی (علوم ریاضی، علوم فیزیکی و شیمی، علوم بیولوژی، علوم پزشکی و علوم اجتماعی) به دبیرخانه جشنواره ارسال شدند.
از این بین پس از داوری توسط بورد مشاورین، ۱۰ نامزد منتخب در هر حیطه معرفی شده اند.

سپاسگزار همراهیتان خواهیم بود اگر دقایقی از وقت خود را در اختیارمان قرار داده و از نگاه خود، به این نامزد ها امتیاز دهید 🙏

لینک فرم ثبت آرا:
http://shorturl.at/cnvW3

📌جهت آشنایی بیشتر با کنگره یوسرن:
https://userncongress.com/

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Memorial Sloan Kettering Cancer Center
Postdoctoral Fellow Adusumilli Lab

✅Memorial Sloan Kettering Cancer Center (MSK) is one of the world’s leading cancer centers. The blending of research with patient care is at the heart of everything they do.

✅They currently have a postdoctoral position available in the Adusumilli Laboratory at MSK:
https://www.mskcc.org/research-areas/labs/prasad-adusumilli
The laboratory’s focus is on developing and translating adoptive T-cell therapy for the treatment of cancers.

✅The ideal candidate will have a PhD or MD/PhD, with a background in immunology, a passion for science, and a desire to advance the understanding and treatment of cancer. 

✅Please send a CV, bibliography, brief statement of research interests, and names and details of three references to:
Krishna Tobon
Grants Coordinator/Editor
tobonk@mskcc.org

#Postdoc_position

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Cancer Immunology and Immunotherapy

🎤Interview with James P. Allison
🏅Nobel Laureate 2018

#Interview
#Nobel

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✒️Write a scientific paper like a pro...

▶️Once per year!
▶️The first and the last Research week of this year!
▶️USERN Research Week
▶️USERN Summer Event
▶️August 24-29, 2019

✔️For more information and registration:
https://docs.google.com/forms/d/e/1FAIpQLSfRTbSIU15Lb9tkyPSacghOW_85EiWj0UHiU-sYeyfxHdzy7w/viewform

#Research

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Natural Killer Cells and Cancer Therapy, What We Know and Where We Are Going

💠New Paper by CIP

Natural killer (NK) cells are among the significant components of innate immune system and they have come to the first line of defense against tumor cells developing inside the body. CD56lo/CD16+ NK cells are highly cytotoxic and CD56hi NK cells can produce cytokines and perform a regulatory function. Specific features of NK cells have made them a unique choice for cancer immunotherapy. Simple interventions like cytokine-injection to boost the internal NK cells were the first trials to target these cells. Nowadays, many other types of intervention are under investigation, such as adoptive NK cell immunotherapy. In this paper, we will discuss the biology and function of NK cells in cancer immunosurveillance and therapeutic approaches against cancer via using NK cells.

https://www.futuremedicine.com/doi/full/10.2217/imt-2019-0040

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Nanoparticle-siRNA: a potential strategy for ovarian cancer therapy?

🌀New paper by CIP

Ovarian cancer is one of the most common causes of mortality throughout the world. Unfortunately, chemotherapy has failed to cure advanced cancers developing multidrug resistance (MDR). Moreover, it has critical side effects because of nonspecific toxicity. Thanks to specific silencing of oncogenes and MDR-associated genes, nano-siRNA drugs can be a great help address the limitations of chemotherapy. Here, we review the current advances in nanoparticle-mediated siRNA delivery strategies such as polymeric- and lipid-based systems, rigid nanoparticles and nanoparticles coupled to specific ligand systems. Nanoparticle-based codelivery of anticancer drugs and siRNA targeting various mechanisms of MDR is a cutting-edge strategy for ovarian cancer therapy, which is completely discussed in this review.


🌀https://www.futuremedicine.com/doi/full/10.2217/nnm-2018-0379

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🌏یوسرن و علم بدون مرز

⁉️چگونه علم بدون مرز به نفع همه ماست؟

سخنرانی تدکس دکتر نیما رضایی موسس و ریاست یوسرن در تدکس تهران 2019

مشاهده از طریق یوتیوب:
https://youtu.be/TtnEZUN8-bQ

مشاهده از طریق آپارات:
https://www.aparat.com/v/ICp1Y

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Nanoparticle-siRNA: a potential strategy for ovarian cancer therapy?

New paper by USERN interest groups

🌀Ovarian cancer is one of the most common causes of mortality throughout the world.

🌀Thanks to specific silencing of oncogenes and MDR-associated genes, nano-siRNA drugs can be a great help address the limitations of chemotherapy.

🌀Here, we review the current advances in nanoparticle-mediated siRNA delivery strategies such as polymeric- and lipid-based systems, rigid nanoparticles and nanoparticles coupled to specific ligand systems.

🌀Nanoparticle-based codelivery of anticancer drugs and siRNA targeting various mechanisms of MDR is a cutting-edge strategy for ovarian cancer.

To read the full paper:
https://www.futuremedicine.com/doi/abs/10.2217/nnm-2018-0379?rfr_dat=cr_pub%3Dpubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&journalCode=nnm

#Paper

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Natural killer cells and cancer therapy, what we know and where we are going

New paper by USERN interest groups

🌀Natural killer (NK) cells are among the significant components of innate immune system and they have come to the first line of defense against tumor cells developing inside the body. CD56lo/CD16+ NK cells are highly cytotoxic and CD56hi NK cells can produce cytokines and perform a regulatory function.

🌀Specific features of NK cells have made them a unique choice for cancer immunotherapy.

🌀Simple interventions like cytokine-injection to boost the internal NK cells were the first trials to target these cells. Nowadays, many other types of intervention are under investigation, such as adoptive NK cell immunotherapy.

🌀Here,the biology and function of NK cells in cancer immunosurveillance and therapeutic approaches against cancer via using NK cells are discussed.

To read the full paper:
https://www.futuremedicine.com/doi/full/10.2217/imt-2019-0040

#Paper

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@cip_usern
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USERN UEEE
🔴دیدار با پرفسور بهرام مبشر، استاد کیهانشناسی دانشگاه ریورساید کالیفرنیا
🕑 سه شنبه دوم مهرماه ساعت ۱۵-۱۳

📚نشست های UEEE با هدف آشنایی بیشتر دانشجویان و محققان جوان با دانشمندان برجسته پایه‌گذاری شده است. علاقه‌مندان می‌توانند در این گپ و گفت صمیمی تجربیات علمی و شخصی دانشمندان موفق را از زبان خودشان بشنوند و سوالات خود را مطرح کنند.

💡با توجه به محدود بودن ظرفیت، متقاضیان محترم با در نظر گرفتن ترتیب ثبت نام، و پس از بررسی انگیزه نامه با اولویت دانشجویان علوم پزشکی انتخاب خواهند شد:
https://forms.gle/9nkaCTAPKgmXCibu8

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Comparison of the effects of adipose tissue mesenchymal stromal cell-derived exosomes with conditioned media on neutrophil function and apoptosis

📑New Paper by CIP


📌Neutrophils have an important role in defending against pathogens by producing reactive oxygen species (ROS). Some studies suggest using multipotent mesenchymal stromal cells (MSCs) and MSC-conditioned media (MSC-CM) for increasing neutrophil's viability and function. But, there is no study on using MSC-derived exosomes for improving neutrophil's viability and function. So, we examined the effects of MSC-exosomes and also MSC-CM on neutrophil's function and survival and compared them with each other.

📌Exosomes and CM were isolated from human adipose tissue MSCs. Exosomes were characterized, and the protein content of them was determined. Neutrophils were isolated from five healthy donors, and the effects of the two independent treatments (exosomes and conditioned media) on neutrophil's apoptosis were measured by Annexin V-PI method, then neutrophil's function was evaluated using NBT and phagocytosis assays.

📌The conditioned media augmented neutrophil's phagocytosis and reactive oxygen species (ROS) production, but it couldn't decrease neutrophil's apoptosis.

📌This report showed that the use of MSC-exosomes and CM might be useful for increasing immunity by improving neutrophil's function and survival.

 https://www.ncbi.nlm.nih.gov/pubmed/31207404

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Attribution of Ghrelin to Cancer; Attempts to Unravel an Apparent Controversy

📑New Paper by CIP


📌 Ghrelin is an endogenous peptide hormone mainly produced in the stomach. It has been known to regulate energy homeostasis, stimulate secretion of growth hormone, and mediate many other physiologic effects. Various effects attributed to ghrelin contribute to many aspects of cancer development and progression.

📌However, existing data are controversial. This controversy occurs in two main domains: one is the controversial results in local effects of ghrelin on different types of human cancer cell-lines; the second is the apparent disagreement in the results of in-vitro and clinical studies that investigated ghrelin association to one type of cancer.

📌 In this study, we comprehensively reviewed in-vitro, in-vivo, and clinical studies and attempted to address local and systemic effects of ghrelin in (a) interpreting its summary clinical role in each cancer; (b) scrutinizing factors that regulate local effects of ghrelin and could justify different effects of ghrelin on different cancer cell-lines.


https://www.frontiersin.org/articles/10.3389/fonc.2019.01014/full


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🎇گردهمایی اهالی علم و هنر در چهارمین سالگرد تاسیس یوسرن

فرصتی برای دیدن، شنیدن و گفتن برای علاقه‌مندان به هنر و علم

در این برنامه شنونده سخنان:
💫 احسان رضایی (نویسنده)
💫 دکتر اذرخش مکری (استاد دانشگاه و روانپزشک)
💫 دکتر حمیدرضا نمازی (پزشك و استاد فلسفه علم و اخلاق)
💫 سیاوش صفاریان پور (چهره شناخته در حیطه ترویج علم)
💫 غزل مهدوی (روانشناس و ترانه سرای گروه دال)
و
💫 سروش صحت (کارگردان، نویسنده و مروج فرهنگ کتابخوانی)
خواهیم بود.

🎼🎤مهمان ویژه این برنامه گروه دال خواهد بود و قطعاتی را بصورت زنده اجرا خواهد کرد.

💠زمان : دهم دی ماه ۱۳۹۸، ساعت ۱۵

💠مکان: سالن شماره يک مرکز طبی کودکان، بلوار كشاورز، خيابان قريب، جنب بیمارستان امام خمینی

📍ثبت نام برای عموم آزاد است.

💠لینک ثبت نام اولیه:

https://bit.ly/2EjZ9EN

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