Novel diagnostic tools to measure retinal function and structure are rapidly being developed and introduced into clinical use. Opportunities exist to use these informative and robust measures as endpoints for clinical trials to determine efficacy and to monitor…

An elevation in intracranial pressure (ICP) lowers conventional outflow facility (increases aqueous outflow resistance) of rat eyes.
The reduction in outflow facility correlates with an increase in ...

Healthy, older adults are widely reported to experience cognitive decline, including impairments in inhibitory control. However, this general proposition has recently come under scrutiny because ageing effects are highly variable between individuals, are…

Purpose To describe the retinal contour in optical coherence tomography (OCT) images, and report the relationship between retinal contour and axial length. Methods Retinal contour was defined by the path of the retinal pigment epithelial (RPE) line in macular…

Neural Networks Mediating Perceptual Learning in Congenital Blindness

Study of the neural deficits caused by mismatched binocular vision in early childhood has predominantly focused on circuits in the primary visual cortex (V1). Recent evidence has revealed that neurons in mouse dorsolateral geniculate nucleus (dLGN) can undergo…

Local inhibition, mediated by thalamic interneurons, contributes to the processing of visual information and is essential for vision. However, the mechanisms underlying the development of these interneurons remains unresolved. In this study, we sought to…

Abstract. In a consanguineous Pakistani family with two affected individuals, a homozygous variant Gly399Val in the eighth transmembrane domain of the taurine

Nature Genetics - Multitrait genome-wide analysis of glaucoma and related phenotypes identifies new risk loci and enables development of a polygenic risk score to predict disease susceptibility and...

DICER1 processes micro-RNAs into their bioactive forms and metabolizes RNAs from short interspersed nuclear element genetic repeats, principally Alu RNAs in humans. DICER1 deficiency is implicated in retinal pigmented epithelium (RPE) degeneration in atrophic…

Purpose
To examine the rate and types of ocular adverse events among children wearing soft contact lenses.

Methods
This study is a retrospective review of ocular adverse event data from six random...

Thyroid eye disease is a debilitating, disfiguring, and potentially blinding periocular
condition for which no Food and Drug Administration–approved medical therapy is available.
Strong evidence ha...

The cellular mechanisms underlying hereditary photoreceptor degeneration are still poorly understood, a problem that is exacerbated by the enormous ge…

This presentation will survey the retinal architecture, advantages, and limitations of several lesser-known rodent species that provide a useful diurn…

As the eye's main load-bearing connective tissue, the sclera is centrally important to vision. In addition to cooperatively maintaining refractive sta…

Quantitative fundus autofluorescence (qAF) is an approach that is built on a confocal scanning laser platform and used to measure the intensity of the…

Extracellular matrices (ECMs) are maintained by tightly coupled processes of continuous synthesis and degradation. The degradative arm is mediated by …