Study of the neural deficits caused by mismatched binocular vision in early childhood has predominantly focused on circuits in the primary visual cortex (V1). Recent evidence has revealed that neurons in mouse dorsolateral geniculate nucleus (dLGN) can undergo…

Local inhibition, mediated by thalamic interneurons, contributes to the processing of visual information and is essential for vision. However, the mechanisms underlying the development of these interneurons remains unresolved. In this study, we sought to…

Abstract. In a consanguineous Pakistani family with two affected individuals, a homozygous variant Gly399Val in the eighth transmembrane domain of the taurine

Nature Genetics - Multitrait genome-wide analysis of glaucoma and related phenotypes identifies new risk loci and enables development of a polygenic risk score to predict disease susceptibility and...

DICER1 processes micro-RNAs into their bioactive forms and metabolizes RNAs from short interspersed nuclear element genetic repeats, principally Alu RNAs in humans. DICER1 deficiency is implicated in retinal pigmented epithelium (RPE) degeneration in atrophic…

Purpose
To examine the rate and types of ocular adverse events among children wearing soft contact lenses.

Methods
This study is a retrospective review of ocular adverse event data from six random...

Thyroid eye disease is a debilitating, disfiguring, and potentially blinding periocular
condition for which no Food and Drug Administration–approved medical therapy is available.
Strong evidence ha...

The cellular mechanisms underlying hereditary photoreceptor degeneration are still poorly understood, a problem that is exacerbated by the enormous ge…

This presentation will survey the retinal architecture, advantages, and limitations of several lesser-known rodent species that provide a useful diurn…

As the eye's main load-bearing connective tissue, the sclera is centrally important to vision. In addition to cooperatively maintaining refractive sta…

Quantitative fundus autofluorescence (qAF) is an approach that is built on a confocal scanning laser platform and used to measure the intensity of the…

Extracellular matrices (ECMs) are maintained by tightly coupled processes of continuous synthesis and degradation. The degradative arm is mediated by …

Objective There has long been a great interest in neuroprotection therapy for ischaemic stroke and various types of optic neuropathies. In view of that, I reviewed the literature on the role of neuroprotection for non-arteritic anterior ischaemic optic neuropathy…

Background/Aims To investigate the risk factors for disease progression of normal-tension glaucoma (NTG) with pretreatment intraocular pressure (IOP) in the low-teens.

Methods One-hundred and two (102) eyes of 102 patients with NTG with pretreatment IOP≤12…

Background To evaluate the diagnostic ability of volumetric parameters to differentiate narrow angle from open angle and distinguish different configurations of narrow angle.

Methods The current study was composed of two parts. In the first part, with gonioscopy…

Background/Aims To investigate the topographic relationship between macular superficial microvessel density (SMD) and macular ganglion cell-inner plexiform layer (GCIPL) thickness in eyes with glaucoma-suspect (GS) and early normal-tension glaucoma (NTG).…

Glaucoma is a result of irreversible damage to the retinal ganglion cells. While an early intervention could minimise the risk of vision loss in glaucoma, its asymptomatic nature makes it difficult to diagnose until a late stage. The diagnosis of glaucoma…

A review of systemic medications that may modulate the risk of glaucoma