Quercetin potential effects against SARS-CoV-2 infection and COVID-19-associated cancer progression by inhibiting mTOR and hypoxia-inducible factor-1α (HIF-1α)
New Paper by USERN Interest Group
🌀Globally, the coronavirus disease-2019 (COVID-19) pandemic has spread rapidly, with millions of confirmed cases.
🌀Based on the studies, it seems that cancer patients not only are more prone to experience severe complications and death by COVID-19, but also cancer progression by COVID-19.
🌀We hypothesize that quercetin, as a safe flavonoid that exists in various fruits and vegetables, not only can be used as an anti-COVID-19 component with potential effects on interfacing the viral entry, replication, and its inflammatory activity but also can disrupt the signaling pathways stimulated and upregulated factors by SARS-CoV-2 infection (e.g., mTOR, HIF-1α, etc.), which may lead to cancer progression.
Source: https://doi.org/10.1002/ptr.7440
@niima_usern
@usern_IntGrp
@usern_net
New Paper by USERN Interest Group
🌀Globally, the coronavirus disease-2019 (COVID-19) pandemic has spread rapidly, with millions of confirmed cases.
🌀Based on the studies, it seems that cancer patients not only are more prone to experience severe complications and death by COVID-19, but also cancer progression by COVID-19.
🌀We hypothesize that quercetin, as a safe flavonoid that exists in various fruits and vegetables, not only can be used as an anti-COVID-19 component with potential effects on interfacing the viral entry, replication, and its inflammatory activity but also can disrupt the signaling pathways stimulated and upregulated factors by SARS-CoV-2 infection (e.g., mTOR, HIF-1α, etc.), which may lead to cancer progression.
Source: https://doi.org/10.1002/ptr.7440
@niima_usern
@usern_IntGrp
@usern_net
Neurological and neuropsychological adverse effects of SARS-CoV-2 vaccines – where do we stand?
New Paper by USERN Interest Group
🌀We discuss different neurological and neuropsychological adverse effects of COVID-19 vaccines including demyelinating diseases, Bell’s palsy (BP), cerebrovascular complications, seizures, functional neurological disorders (FNDs), and some other rare adverse events, and hypothetical mechanisms which can lead to the reported side effects.
🌀Given the fact that the incidence of such events are rare and most of them are treatable, the current review aims to shed light on how much the relationship between COVID-19 vaccines and these complications can be reliable.
Source: https://doi.org/10.1515/revneuro-2022-0006
@niima_usern
@usern_IntGrp
@usern_net
New Paper by USERN Interest Group
🌀We discuss different neurological and neuropsychological adverse effects of COVID-19 vaccines including demyelinating diseases, Bell’s palsy (BP), cerebrovascular complications, seizures, functional neurological disorders (FNDs), and some other rare adverse events, and hypothetical mechanisms which can lead to the reported side effects.
🌀Given the fact that the incidence of such events are rare and most of them are treatable, the current review aims to shed light on how much the relationship between COVID-19 vaccines and these complications can be reliable.
Source: https://doi.org/10.1515/revneuro-2022-0006
@niima_usern
@usern_IntGrp
@usern_net
Hyper IgE syndromes: A clinical approach
New Paper by USERN Interest Group
🌀There are several distinct immunodeficiency disorders which are phenotypically similar to HIES.
🌀The diagnosis of HIES is typically based on the clinical suspicion and immunological assessments.
🌀The genetic diagnosis is important for the therapeutic approaches.
Source: https://doi.org/10.1016/j.clim.2022.108988
@niima_usern
@usern_IntGrp
@usern_net
New Paper by USERN Interest Group
🌀There are several distinct immunodeficiency disorders which are phenotypically similar to HIES.
🌀The diagnosis of HIES is typically based on the clinical suspicion and immunological assessments.
🌀The genetic diagnosis is important for the therapeutic approaches.
Source: https://doi.org/10.1016/j.clim.2022.108988
@niima_usern
@usern_IntGrp
@usern_net
Acute disseminated encephalomyelitis (ADEM) after SARS- CoV-2 vaccination: A case report
New Paper by USERN Interest Group
🌀Here, we present a 37 y/o male patient with progressive muscle weakness in all limbs along with dysphagia following COVID-19 vaccination.
🌀Brain magnetic resonance imaging (MRI) revealed typical imaging findings which presented as multifocal T2-FLAIR signal changes in the corticospinal tract, pons, and temporal lobe with diffusion restriction.
🌀Magnetic resonance spectroscopy (MRS) further confirmed the diagnosis by the typical elevation of the Choline and Myoinositol peaks.
Source: https://doi.org/10.1016/j.radcr.2022.03.013
@niima_usern
@usern_IntGrp
@usern_net
New Paper by USERN Interest Group
🌀Here, we present a 37 y/o male patient with progressive muscle weakness in all limbs along with dysphagia following COVID-19 vaccination.
🌀Brain magnetic resonance imaging (MRI) revealed typical imaging findings which presented as multifocal T2-FLAIR signal changes in the corticospinal tract, pons, and temporal lobe with diffusion restriction.
🌀Magnetic resonance spectroscopy (MRS) further confirmed the diagnosis by the typical elevation of the Choline and Myoinositol peaks.
Source: https://doi.org/10.1016/j.radcr.2022.03.013
@niima_usern
@usern_IntGrp
@usern_net
Cytokine-induced killer cells mediated pathways in the treatment of colorectal cancer
New Paper by USERN Interest Group
🌀Cytokine-induced killer (CIK) cell therapy is a type of adoptive immunotherapy that due to its high proliferation rate and anti-tumor characteristics, is being investigated to treat various solid tumors.
🌀This review aims to summarize the clinical studies that investigated the safety and clinical efficacy of CIK cell therapy in CRC.
Source: https://doi.org/10.1186/s12964-022-00836-0
@niima_usern
@usern_IntGrp
@usern_net
New Paper by USERN Interest Group
🌀Cytokine-induced killer (CIK) cell therapy is a type of adoptive immunotherapy that due to its high proliferation rate and anti-tumor characteristics, is being investigated to treat various solid tumors.
🌀This review aims to summarize the clinical studies that investigated the safety and clinical efficacy of CIK cell therapy in CRC.
Source: https://doi.org/10.1186/s12964-022-00836-0
@niima_usern
@usern_IntGrp
@usern_net
Forwarded from Alzheimer’s Disease Institute
The latest publication by the NRG interest group
Autoimmune encephalitis after COVID-19 infection
https://www.msard-journal.com/article/S2211-0348(22)00302-9/fulltext
@nrg_usern
Autoimmune encephalitis after COVID-19 infection
https://www.msard-journal.com/article/S2211-0348(22)00302-9/fulltext
@nrg_usern
📕Encyclopedia of Infection and Immunity
Reference Work • 2022
New Book by USERN Interest Group
📗Editor-in-Chief: Nima Rezaei
🔹Department of Immunology, School of Medicine, Tehran University of Medical Sciences,
🔹Research Center for Immunodeficiencies, Children's Medical Center,
🔹Universal Scientific Education and Research Network (USERN)
📘Four Volume Set provides new insights into the interactions between bacteria, fungi, parasites and their host innate and adaptive immune response.
📙Comprised of over 200 chapters (3200 pages) written and edited by leading experts in the field, this book will serve as a key resource for students, researchers, academics and industry practitioners in the fields of microbiology, immunology, and infectious diseases.
https://www.sciencedirect.com/referencework/9780323903035/encyclopedia-of-infection-and-immunity
@niima_usern
@usern_net
Reference Work • 2022
New Book by USERN Interest Group
📗Editor-in-Chief: Nima Rezaei
🔹Department of Immunology, School of Medicine, Tehran University of Medical Sciences,
🔹Research Center for Immunodeficiencies, Children's Medical Center,
🔹Universal Scientific Education and Research Network (USERN)
📘Four Volume Set provides new insights into the interactions between bacteria, fungi, parasites and their host innate and adaptive immune response.
📙Comprised of over 200 chapters (3200 pages) written and edited by leading experts in the field, this book will serve as a key resource for students, researchers, academics and industry practitioners in the fields of microbiology, immunology, and infectious diseases.
https://www.sciencedirect.com/referencework/9780323903035/encyclopedia-of-infection-and-immunity
@niima_usern
@usern_net
Forwarded from Alzheimer’s Disease Institute
♦️The latest publication by NRG♦️
Pseudobulbar affect is a missed diagnosed complication that can be observed in neurodegenerative diseases. In this study, we evaluate the prevalence of PBA in Alzheimer’s disease, Parkinson’s disease, Multiple sclerosis and amyotrophic lateral sclerosis.
https://www.sciencedirect.com/science/article/abs/pii/S0967586822001679
@NRG_USERN
Pseudobulbar affect is a missed diagnosed complication that can be observed in neurodegenerative diseases. In this study, we evaluate the prevalence of PBA in Alzheimer’s disease, Parkinson’s disease, Multiple sclerosis and amyotrophic lateral sclerosis.
https://www.sciencedirect.com/science/article/abs/pii/S0967586822001679
@NRG_USERN
Role of serology tests in COVID-19 non-hospitalized patients: A cross-sectional study
New Paper by USERN Interest Group
🌀We have surveyed 1,363 outpatients with suspected COVID-19 in Tehran, Iran. The analysis emphasized on characteristics of patients with positive PCR or serology of SARS-CoV-2.
🌀Conclusion: Assessing antibody titers in outpatients is invaluable due to the epidemiological importance of investigations in mild or even asymptomatic cases. Since the number of such studies in non-hospitalized patients is not high, the current study can be used as a comparison model.
Source: https://doi.org/10.1371/journal.pone.0266923
@niima_usern
New Paper by USERN Interest Group
🌀We have surveyed 1,363 outpatients with suspected COVID-19 in Tehran, Iran. The analysis emphasized on characteristics of patients with positive PCR or serology of SARS-CoV-2.
🌀Conclusion: Assessing antibody titers in outpatients is invaluable due to the epidemiological importance of investigations in mild or even asymptomatic cases. Since the number of such studies in non-hospitalized patients is not high, the current study can be used as a comparison model.
Source: https://doi.org/10.1371/journal.pone.0266923
@niima_usern
Forwarded from Alzheimer’s Disease Institute
♦️The latest publication by NRG♦️
Pseudobulbar affect is a missed diagnosed complication that can be observed in neurodegenerative diseases. In this study, we evaluate the prevalence of PBA in Alzheimer’s disease, Parkinson’s disease, Multiple sclerosis and amyotrophic lateral sclerosis.
https://www.sciencedirect.com/science/article/abs/pii/S0967586822001679
@NRG_USERN
Pseudobulbar affect is a missed diagnosed complication that can be observed in neurodegenerative diseases. In this study, we evaluate the prevalence of PBA in Alzheimer’s disease, Parkinson’s disease, Multiple sclerosis and amyotrophic lateral sclerosis.
https://www.sciencedirect.com/science/article/abs/pii/S0967586822001679
@NRG_USERN
Forwarded from Alzheimer’s Disease Institute
⭐️Our latest publication⭐️
Longitudinal assessment of CSF biomarkers in Parkinson’s disease patients with REM sleep behavioral disorder
In this study, we assessed the longitudinal level of CSF biomarkers in Parkinson’s disease patients with REM sleep behavioral disorder
The level of Amyloid Beta showed interesting changes in two year follow-up
https://link.springer.com/article/10.1007/s00415-022-11120-z
@NRG_USERN
Longitudinal assessment of CSF biomarkers in Parkinson’s disease patients with REM sleep behavioral disorder
In this study, we assessed the longitudinal level of CSF biomarkers in Parkinson’s disease patients with REM sleep behavioral disorder
The level of Amyloid Beta showed interesting changes in two year follow-up
https://link.springer.com/article/10.1007/s00415-022-11120-z
@NRG_USERN
Forwarded from CIP, Cancer Immunology Project
Interleukin 17, the double-edged sword in atherosclerosis
New paper by CIP Members
🌀Cardiovascular diseases, including atherosclerosis, are the number one cause of death worldwide
🌀Atherosclerosis is an inflammatory disease. Therefore, immunological signaling molecules and immune cells carry out a central role in its etiology.
🌀IL-17 might have a dual role as acting both pro-atherogenic and anti-atherogenic depending on the situation.
🌀In this review, the immunological basis of atherosclerosis with an emphasis on the role of IL-17 and a brief explanation of the role of IL-17 on atherosclerogenic disorders will be discussed.
🌐More at: https://authors.elsevier.com/a/1exL3cykBZUnK
@cip_usern
@usern_IntGrp
@usern_net
New paper by CIP Members
🌀Cardiovascular diseases, including atherosclerosis, are the number one cause of death worldwide
🌀Atherosclerosis is an inflammatory disease. Therefore, immunological signaling molecules and immune cells carry out a central role in its etiology.
🌀IL-17 might have a dual role as acting both pro-atherogenic and anti-atherogenic depending on the situation.
🌀In this review, the immunological basis of atherosclerosis with an emphasis on the role of IL-17 and a brief explanation of the role of IL-17 on atherosclerogenic disorders will be discussed.
🌐More at: https://authors.elsevier.com/a/1exL3cykBZUnK
@cip_usern
@usern_IntGrp
@usern_net
Novel NFkB mutation in a case of lymphoproliferative disorder case report
New Paper by USERN Interest Group
🌀A young boy presented with symptoms overlapping different lymphoproliferative disorders including episodes of chronic respiratory tract infections, dysgammaglobulinemia, lymphadenopathy associated with splenomegaly as well as skin rashes. Genetic studies revealed multiple heterozygous variants including a novel mutation in NFκB1 gene.
🌀This novel mutation can reveal new aspects in the pathogenesis of lymphoproliferative disorders and propose new treatments for them.
Source: http://dx.doi.org/10.2174/1871530322666220407091356
@niima_usern
@usern_IntGrp
@usern_net
New Paper by USERN Interest Group
🌀A young boy presented with symptoms overlapping different lymphoproliferative disorders including episodes of chronic respiratory tract infections, dysgammaglobulinemia, lymphadenopathy associated with splenomegaly as well as skin rashes. Genetic studies revealed multiple heterozygous variants including a novel mutation in NFκB1 gene.
🌀This novel mutation can reveal new aspects in the pathogenesis of lymphoproliferative disorders and propose new treatments for them.
Source: http://dx.doi.org/10.2174/1871530322666220407091356
@niima_usern
@usern_IntGrp
@usern_net
Recent advances in passive immunotherapies for COVID-19: The Evidence-Based approaches and clinical trials
New Paper by USERN Interest Groups
🌀Challenges regarding the SARS-CoV-2 vaccination have remained unanswered.
🌀At this time, there is no specific treatment for COVID-19-induced cytokine storm.
🌀Passive immunotherapy is a promising way to manage COVID-19.
🌀Inflammatory molecules are appropriate targets to alleviate COVID-19.
🌀This article highlights passive immunotherapy and immunomodulation approaches in managing and treating COVID-19 patients and discusses relevant clinical trials.
Source: https://doi.org/10.1016/j.intimp.2022.108786
@niima_usern
@immunology_board
New Paper by USERN Interest Groups
🌀Challenges regarding the SARS-CoV-2 vaccination have remained unanswered.
🌀At this time, there is no specific treatment for COVID-19-induced cytokine storm.
🌀Passive immunotherapy is a promising way to manage COVID-19.
🌀Inflammatory molecules are appropriate targets to alleviate COVID-19.
🌀This article highlights passive immunotherapy and immunomodulation approaches in managing and treating COVID-19 patients and discusses relevant clinical trials.
Source: https://doi.org/10.1016/j.intimp.2022.108786
@niima_usern
@immunology_board
Forwarded from CIP, Cancer Immunology Project
Tumor-infiltrating lymphocyte therapy for lung cancer and its future paradigms
New paper by CIP Members
🔹Lung cancer is the leading cause of cancer-related death worldwide.
🔹Tumor-infiltrating lymphocyte (TIL) therapy is an adoptive cell therapy technique, that is being studied for various types of cancer, especially melanoma.
🔹The immunogenic tumor microenvironment of lung cancer makes it a possible candidate for immunotherapy treatments such as TIL therapy.
🔹Currently available results are undecisive on the efficacy and safety of TIL therapy for lung cancer and several clinical trials are in the process of further evaluating this method.
🔹TIL therapy could be enhanced using modifications such as gene editing or incorporating TWS119, although further studies are needed to establish their effectiveness.
For more: https://www.tandfonline.com/doi/abs/10.1080/14712598.2022.2072206?journalCode=iebt20
@cip_usern
@usern_intgrp
@usern_net
New paper by CIP Members
🔹Lung cancer is the leading cause of cancer-related death worldwide.
🔹Tumor-infiltrating lymphocyte (TIL) therapy is an adoptive cell therapy technique, that is being studied for various types of cancer, especially melanoma.
🔹The immunogenic tumor microenvironment of lung cancer makes it a possible candidate for immunotherapy treatments such as TIL therapy.
🔹Currently available results are undecisive on the efficacy and safety of TIL therapy for lung cancer and several clinical trials are in the process of further evaluating this method.
🔹TIL therapy could be enhanced using modifications such as gene editing or incorporating TWS119, although further studies are needed to establish their effectiveness.
For more: https://www.tandfonline.com/doi/abs/10.1080/14712598.2022.2072206?journalCode=iebt20
@cip_usern
@usern_intgrp
@usern_net
Forwarded from Alzheimer’s Disease Institute
🟢The latest publication by NRG🟢
In this study, we provide an overview of FDG-PET imaging findings in autoimmune encephalitis (AE) patients and possible relation to different types and clinical features. These results may help clinicians to better diagnose and also predict future clinical symptoms of subjects with AE.
https://link.springer.com/article/10.1007/s10072-022-06094-9
@NRG_USERN
In this study, we provide an overview of FDG-PET imaging findings in autoimmune encephalitis (AE) patients and possible relation to different types and clinical features. These results may help clinicians to better diagnose and also predict future clinical symptoms of subjects with AE.
https://link.springer.com/article/10.1007/s10072-022-06094-9
@NRG_USERN
Forwarded from NINI_USERN
Updates on Pediatric Health and Diseases: Common Pediatric Diseases: An Updated Review
📘Editor-in-chief: Prof. Nima Rezaei
📙A New Book Series by USERN
📗Publisher: Bentham Science
https://benthambooks.com/book/9789815039658
📖The “Updates on Pediatric Health and Disease” series are a comprehensive text regarding childhood and adolescence health and diseases. Neonatology as well as different diseases in all subspecialties of pediatrics, pediatric surgery and anesthesiology, as well as other surgical subspecialties will be discussed in the “Pediatrics” series.
#USERN
#Book
#Pediatrics
👶🏿👶🏾👶🏽👶🏼👶🏻👶👶🏻👶🏼👶🏽👶🏾👶🏿
@NINI_USERN
@sbmusern
@USERN_net
📘Editor-in-chief: Prof. Nima Rezaei
📙A New Book Series by USERN
📗Publisher: Bentham Science
https://benthambooks.com/book/9789815039658
📖The “Updates on Pediatric Health and Disease” series are a comprehensive text regarding childhood and adolescence health and diseases. Neonatology as well as different diseases in all subspecialties of pediatrics, pediatric surgery and anesthesiology, as well as other surgical subspecialties will be discussed in the “Pediatrics” series.
#USERN
#Book
#Pediatrics
👶🏿👶🏾👶🏽👶🏼👶🏻👶👶🏻👶🏼👶🏽👶🏾👶🏿
@NINI_USERN
@sbmusern
@USERN_net
Forwarded from Alzheimer’s Disease Institute
🔹Latest study by NRG🔹
In this study, we found that factory dysfunction is associated with striatal dopamine uptake only in tremor dominant Parkinsons' disease patients. Therefore it might be an early predictor of dopaminergic loss in specific motor subtypes of PD.
https://link.springer.com/article/10.1007/s10072-022-06110-y
@NRG_USERN
In this study, we found that factory dysfunction is associated with striatal dopamine uptake only in tremor dominant Parkinsons' disease patients. Therefore it might be an early predictor of dopaminergic loss in specific motor subtypes of PD.
https://link.springer.com/article/10.1007/s10072-022-06110-y
@NRG_USERN
Forwarded from شبکه پزشکی بازساختی یوسرن | ReMed
New Review Paper on extrusion-based 3D printing by USERN's Regenerative Medicine (ReMed) Group: Applying extrusion-based 3D printing technique accelerates fabricating complex biphasic calcium phosphate-based scaffolds for bone tissue regeneration
🌀 Biphasic calcium phosphates (BCPs) offer a chemically similar biomaterial to the natural bone, which can significantly promote cell proliferation and differentiation and accelerate bone formation and reconstruction.
🌀 Recent advancements and existing challenges in the use of additives for bioink preparation are critically discussed.
🌀 Commercialization and marketing approach, post-processing steps, clinical applications, in-vitro and in-vivo evaluations beside the biological responses are also reviewed.
🌀 Finally, possible strategies and opportunities for the use of BCP toward injured bone regeneration are discussed.
Read the full text here:
https://doi.org/10.1016/j.jare.2021.12.012
@Usern_Remed
🌀 Biphasic calcium phosphates (BCPs) offer a chemically similar biomaterial to the natural bone, which can significantly promote cell proliferation and differentiation and accelerate bone formation and reconstruction.
🌀 Recent advancements and existing challenges in the use of additives for bioink preparation are critically discussed.
🌀 Commercialization and marketing approach, post-processing steps, clinical applications, in-vitro and in-vivo evaluations beside the biological responses are also reviewed.
🌀 Finally, possible strategies and opportunities for the use of BCP toward injured bone regeneration are discussed.
Read the full text here:
https://doi.org/10.1016/j.jare.2021.12.012
@Usern_Remed
Microbial Metabolites in Multiple Sclerosis: Implications for Pathogenesis and Treatment
New Paper by USERN Interest Group
🌀Metabolites produced by the gut microbiota have been shown to play an important role in numerous inflammatory, neuropsychiatric, and neurodegenerative diseases.
🌀In this review, we discuss the importance of these metabolites as factors contributing to disease pathogenesis and as therapeutic targets in MS. Establishing an improved understanding of these gut-microbiota derived metabolites may provide new avenues for the treatment of MS.
Source: https://doi.org/10.3389/fnins.2022.885031
@niima_usern
New Paper by USERN Interest Group
🌀Metabolites produced by the gut microbiota have been shown to play an important role in numerous inflammatory, neuropsychiatric, and neurodegenerative diseases.
🌀In this review, we discuss the importance of these metabolites as factors contributing to disease pathogenesis and as therapeutic targets in MS. Establishing an improved understanding of these gut-microbiota derived metabolites may provide new avenues for the treatment of MS.
Source: https://doi.org/10.3389/fnins.2022.885031
@niima_usern
Forwarded from Nanomedicine Research Association (NRA)
🔔 A recent publication by NRA
"Curcumin: A potential therapeutic natural product for adenocarcinomas"
🔸️ As a pharmacological option for the treatment of adenocarcinomas, curcumin has been widely used in combination with various therapeutic modalities
🔸️ This review article aimed to survey recent findings on the role of curcumin in the treatment of adenocarcinomas in several organs and described key players of underlying molecular pathways such as the anti-proliferative, anti-apoptosis, anti-metastasis, anti-inflammatory, and immunomodulatory mechanisms.
🔸️ We also described new approaches to producing curcumin-loaded nanoparticles and combinatorial regimens.
🔸️ The present review provides a comprehensive view of the therapeutic aspects of curcumin as a treatment for multiple human adenocarcinomas, which warrants further investigation in clinical settings.
🔸️Full text:
https://www.sciencedirect.com/science/article/abs/pii/S187439002200043X
"Curcumin: A potential therapeutic natural product for adenocarcinomas"
🔸️ As a pharmacological option for the treatment of adenocarcinomas, curcumin has been widely used in combination with various therapeutic modalities
🔸️ This review article aimed to survey recent findings on the role of curcumin in the treatment of adenocarcinomas in several organs and described key players of underlying molecular pathways such as the anti-proliferative, anti-apoptosis, anti-metastasis, anti-inflammatory, and immunomodulatory mechanisms.
🔸️ We also described new approaches to producing curcumin-loaded nanoparticles and combinatorial regimens.
🔸️ The present review provides a comprehensive view of the therapeutic aspects of curcumin as a treatment for multiple human adenocarcinomas, which warrants further investigation in clinical settings.
🔸️Full text:
https://www.sciencedirect.com/science/article/abs/pii/S187439002200043X