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Universal Scientific Education and Research Network (USERN) Interest Groups & Offices Channel

Learn more about USERN Groups & Offices on the website: https://usern.org/page/groups-wvzj
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New Review Paper on extrusion-based 3D printing by USERN's Regenerative Medicine (ReMed) Group: Applying extrusion-based 3D printing technique accelerates fabricating complex biphasic calcium phosphate-based scaffolds for bone tissue regeneration

🌀 Biphasic calcium phosphates (BCPs) offer a chemically similar biomaterial to the natural bone, which can significantly promote cell proliferation and differentiation and accelerate bone formation and reconstruction.

🌀 Recent advancements and existing challenges in the use of additives for bioink preparation are critically discussed.

🌀 Commercialization and marketing approach, post-processing steps, clinical applications, in-vitro and in-vivo evaluations beside the biological responses are also reviewed.

🌀 Finally, possible strategies and opportunities for the use of BCP toward injured bone regeneration are discussed.


Read the full text here:
https://doi.org/10.1016/j.jare.2021.12.012

@Usern_Remed
Microbial Metabolites in Multiple Sclerosis: Implications for Pathogenesis and Treatment

New Paper by USERN Interest Group

🌀Metabolites produced by the gut microbiota have been shown to play an important role in numerous inflammatory, neuropsychiatric, and neurodegenerative diseases. 

🌀In this review, we discuss the importance of these metabolites as factors contributing to disease pathogenesis and as therapeutic targets in MS. Establishing an improved understanding of these gut-microbiota derived metabolites may provide new avenues for the treatment of MS.

Source: https://doi.org/10.3389/fnins.2022.885031

@niima_usern
🔔 A recent publication by NRA

"Curcumin: A potential therapeutic natural product for adenocarcinomas"

🔸️ As a pharmacological option for the treatment of adenocarcinomas, curcumin has been widely used in combination with various therapeutic modalities

🔸️ This review article aimed to survey recent findings on the role of curcumin in the treatment of adenocarcinomas in several organs and described key players of underlying molecular pathways such as the anti-proliferative, anti-apoptosis, anti-metastasis, anti-inflammatory, and immunomodulatory mechanisms.

🔸️ We also described new approaches to producing curcumin-loaded nanoparticles and combinatorial regimens.

🔸️ The present review provides a comprehensive view of the therapeutic aspects of curcumin as a treatment for multiple human adenocarcinomas, which warrants further investigation in clinical settings.

🔸️Full text:
https://www.sciencedirect.com/science/article/abs/pii/S187439002200043X
Vascular endothelial growth factor levels in tuberculosis: A systematic review and meta-analysis

New Paper by USERN Interest Groups

🌀Changes in endothelial function are implicated in the spread of tuberculosis (TB). Studies suggest a role for the vascular endothelial growth factor (VEGF) in TB-related endothelial function changes. 

🌀Meta-analysis findings align with the hypothesis that TB may be associated with abnormal vascular function, and both local and systemic levels of VEGF can be used to trace this abnormality.

Source: https://doi.org/10.1371/journal.pone.0268543

@srmeg_usern
@niima_usern
Natural killer cells and acute myeloid leukemia: promises and challenges

New Paper by USERN Interest Group

🌀 the past few decades, despite substantial progresses in the management of AML, relapse remission remains a major problem. 

🌀It has been a growing knowledge of therapeutic magnitudes ranging from adoptive NK cell transfer to chimeric antigen receptor NK cells, aiming to achieve better therapeutic responses in patients with AML.

Source: https://doi.org/10.1007/s00262-022-03217-1

@niima_usern
Forwarded from USERN
⛑️ FAITH: First Aid for International Health

✳️ FAITH is a 3-day online event organized by USERN Junior Ambassadors of Bahrain, India, Kyrgyzstan, Kenya, Indonesia, and the Gambia.

‼️ If you want to learn the fundamentals of first aid, don't hesitate and join the "FAITH" webinars!

➡️ 1st day details:

🔷 Topic: FAEMED (First Aid in Emergency Medicine)

🗣 Opening Session:
By Dr. Nima Rezaei

👨‍🏫 Lecturers:
Dr. Yasir Rashid
Dr. Jawaid Shaw
Mr. Januaris Kasanga

🗓️ Date: June 14th, 2022

Time: 11:30—13:30 GMT (16:00—18:00 Tehran Time)

💻 Platforms:
1) Zoom
2) YouTube (Live)

🌀Language: English

⚠️ Registration fee: Free!

📄 Certificates of attendance will be provided to all registered participants!

📝 For registration tap/click here.

ℹ️ You can also join our sessions in Persian and Indonesian, visit our website for more information.

@usern_net
Targeting signaling pathways involved in primordial follicle growth or dormancy: potential application in prevention of follicular loss and infertility

New Paper by USERN Interest Group

🌀Premature ovarian failure (POF) is one of the important causes of infertility in females. To date, no efficient preventive pharmacological treatment has been offered to prevent POF.

🌀Therefore, it is necessary to focus on strategies that provide a normal reproductive lifespan to females at risk of developing POF.

Source: https://doi.org/10.1080/14712598.2022.2086042

@niima_usern
The role of Toll-like receptors and neuroinflammation in Parkinson’s disease

New Paper by USERN Interest Group

🌀Although the presence of inflammation in acute phases of PD might have protective effects concerning the clearance of α-synuclein and delaying the disease advancement, the chronic activation of TLRs and neuroinflammation might lead to neurodegeneration, resulting in the disease progression. 

🌀This article aimed to review additional evidence of the contribution of TLRs and neuroinflammation to PD pathogenesis, with the hope that TLRs could serve as novel disease-modifying therapeutic targets in PD patients in the future.

Source: https://doi.org/10.1186/s12974-022-02496-w

@niima_usern
Investigation of BRCAness associated miRNA-gene axes in breast cancer: cell-free miR-182-5p as a potential expression signature of BRCAness

New Paper by CIP Members

🔷The concept of the ‘BRCAness’ phenotype implies the properties that some sporadic breast cancers (BC) share with BRCA1/2-mutation carriers with hereditary BC.

🔷The current study aims to evaluate the expression level of some critical miRNAs-mRNA axes in HRR pathway in tumors and plasma samples from BC patients. 

🔷Our results highlight the difference between TNBC and non-TNBC tumor subgroups regarding the dysregulation of the key miRNA/mRNA axes involved in the HRR pathway. Also, for the first time, we show that the level of cell-free miR-182-5p in plasma samples from BC patients could be a clue for screening BC patients eligible for receiving PARP inhibitors through a personalized manner.

For more: https://doi.org/10.1186/s12885-022-09761-4

@cip_usern
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@usern_intgrp
Prospect of exosomal circular RNAs in breast Cancer: presents and future

New paper by CIP Members

🔹Implementing precision oncology for breast cancer (BC) is a critical method for improving patient outcomes, which relies on the use of reliable biomarkers.

🔹Exosomes represent a potential alternative for the diagnosis and therapy of BC, As a “liquid biopsy” and a novel source for biomarkers.

🔹Circular RNAs (circRNAs) were recently revealed as a looping subclass of competing endogenous noncoding RNAs (ceRNAs) capable of microRNA sponging to regulate gene expression.

🔹CircRNAs are abundant in exosomes, according to various studies, and exosomal circRNAs (exo-circRNAs) play a significant role in cancer biology.

🔹Exo-circRNAs can be picked up by nearby or distant cells, affecting many features of the target cells’ pathophysiological states, thus boosting cell communication and tumor spread.

For more: https://link.springer.com/article/10.1007/s11033-022-07472-4


@cip_usern
@usern_net
@usern_intgrp
The role of epigenetic modifications in drug resistance and treatment of breast cancer

New Paper by USERN Interest Group

🌀It has recently been reported that epigenetic processes such as DNA methylation and histone modification, as well as microRNAs (miRNAs), have potently contributed to the pathophysiology, diagnosis, and treatment of breast cancer.

🌀Herein we discuss the molecular and epigenetic mechanisms underlying breast cancer progression and resistance as well as various aspects of epigenetic-based therapies as monotherapy and combined with immunotherapy.

Source: https://doi.org/10.1186/s11658-022-00344-6

@niima_usern
Forwarded from USERN Miniature Talk
تاک اسکول: بزرگ ترین رویداد آموزش سخنرانی یوسرن

مدرسه سخنرانی یوسرن رویداد تخصصی شش روزه در حوزه سخنرانی است.

در این رویداد زیر نظر مدرسان مطرح کشوری آموزش دیده و مهارت های سخنوری خود را ارتقا می‌دهید.

📝 سرفصل های مدرسه سخنرانی:

✔️ History and models of talks
✔️ Story telling and writing scenarios
✔️ Data visualization and concept mapping
✔️ Stage management
✔️ Presentation skills
✔️ چگونه بهتر حرف بزنیم؟
✔️ اصول و مبانی گویندگی و اجرا
✔️ در آشپزخانه تولید محتوا
✔️ فن بيان، كنترل صدا و نقطه طلايى صدا


❇️ علاوه بر آموزش، یادگیری و تعامل با اساتید می‌توانید سخنرانی های سومین مرحله رقابت مینیاتورتاک ۲۰۲۲ را با توجه به مطالبی که آموختید داوری کنید.

💳 سرتیفیکیت: سرتیفیکیت شرکت در رویداد، از طرف یوسرن اعطا خواهد شد.

زمان: یکم تا ششم مرداد

📍مکان: تهران، انتهای بلوار کشاورز، مرکز طبی کودکان

اطلاعات بیشتر و ثبت نام
https://evand.com/events/usern-talkschool

+ سوالات متداول را از اینجا ببینید.

+ با ما از طریق آیدی تلگرام زیر در ارتباط باشید:
@MTalk_USERN

@usern_net
We are delighted to share the last comprehensive review paper, Commercialization and regulation of regenerative medicine products: Promises, advances and challenges, published in Biomedicine & Pharmacotherapy.

We discussed in this paper on regenerative medicine products, emphasizing that:

• All efforts in regenerative medicine must proceed through in silico, in vitro, in vivo, and clinical trials before they can move from the bench to the bedside.

• Due to extensive regulations, principles, and financial requirements, a few regenerative medicine products have been commercialized.

• Various monitoring centers promote the evaluation and commercialization of these products under design control procedures.

• This comprehensive review includes the development, processes, regulatory concerns, and immunological considerations of regenerative medicine.

Find the open access full text from:

https://lnkd.in/e3gDerHg


@Usern_Remed

@USERN_net
Forwarded from PPIG public channel
#PPIG_PAPER
چاپ مقاله فیتوفارماکولوژی با عنوان
A literature review of the studies concerning selected plant-derived adaptogens and their general function in body with a focus on animal studies

در مجله
Phytomedicine
با ایمپکت فاکتور ۶.۶۵۶

مقالات ما را با هشتگ
#PPIG_PAPER

در کانال عمومی تلگرام و صفحه اینستاگرام فیتوفارماکولوژی دنبال کنید.

https://www.sciencedirect.com/science/article/abs/pii/S0944711322004330

@ppigpublicity
Forwarded from PPIG public channel
#PPIG_PAPER

چاپ مقاله با همکاری گروه فیتوفارماکولوژی با عنوان

Scientometric assessment of scientific documents published in 2020 on herbal medicines used for COVID-19

در مجله
Journal of Herbal Medicine

با ایمپکت فاکتور
2.5

مقالات ما را با هشتگ
#PPIG_PAPER

در کانال تلگرام و صفحه اینستاگرام گروه فیتوفارماکولوژی دنبال کنید.

@ppigpublicity
@usern_net


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272664/
Forwarded from PPIG public channel
#PPIG_PAPER

چاپ مقاله گروه فیتوفارماکولوژی با عنوان

Apigenin and its dermatological applications: A comprehensive review

در مجله
Phytochemistry

با ایمپکت فاکتور
4.004

مقالات ما را با هشتگ
#PPIG_PAPER

در کانال تلگرام و صفحه اینستاگرام گروه فیتوفارماکولوژی دنبال کنید.

@ppigpublicity
@usern_net


https://www.sciencedirect.com/science/article/abs/pii/S0031942222003065
The latest publication by CIP members

Melatonin and cancer suppression: insights into its effects on DNA methylation

Learn more at https://doi.org/10.1186/s11658-022-00375-z

@cip_usern
@usern_net
Forwarded from PPIG public channel
#PPIG_PAPER

چاپ مقاله گروه فیتوفارماکولوژی با عنوان

Nanoformulations of Plant-Derived Compounds as Emerging Therapeutic Approach for Colorectal Cancer.

در ژورنال

Current Drug Delivery

با ایمپکت فاکتور ۳.۷

مقالات ما را با هشتگ
#PPIG_PAPER

در کانال عمومی تلگرام و صفحه اینستاگرام فیتوفارماکولوژی دنبال کنید.

@ppigpublicity
@usern_net


https://europepmc.org/article/med/36017863
گروه اخترزیست شناسی و زیست فضایی USERN برگزار میکند:

💫دوره آنلاین اخترزیست شناسی مقدماتی💫
مدرس: صالحه عبادی‌راد، کاندیدای دکتری شیمی زمین و محقق اخترزیست‌شناسی از دانشگاه ریورساید کالیفرنیا

📌تعداد جلسات: ۶ جلسه
📌زمان برگزاری: روزهای شنبه و یکشنبه، ساعت ۱۹_۲۰:۳۰

🗓شروع دوره از ۲۰ خردادماه ۱۴۰۲

📧 به همراه ارائه گواهی نامه الکترونیکی
💰قیمت دوره: ۲۵۰ هزار تومان

٪۳۰ تخفیف برای ۱۰ نفر اول

لینک ثبت نام
@usern_net
@SBART_USERN
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▪️دپارتمان اینترست گروپ‌های یوسرن، با نهایت تاسف و تاثر، درگذشت خانم نسرین سیدپور، مدیر اجرایی گروه Nanomedicine Research Association را به خانواده محترم ایشان و جامعه علمی تسلیت می‌گوید.

@usern_IntGrp
@usern_net
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