Noooo China Noooooo!

"[.] Vaccine Hesitancy Among Medical Students: The Next COVID-19 Challenge in Wuhan, China

The main factors:

⟿ knowledge about COVID-19 vaccine,
⟿ training related to COVID-19 vaccines,
⟿ education level."

https://pubmed.ncbi.nlm.nih.gov/34496990/

Spike-Only-Focus-Shitshow-Fest-Collection:
https://threadreaderapp.com/thread/1447787430233481218?refresh=1635109424

Nooooo Boston Nooooooo!

Quote:
"Breakthrough cases in Massachusetts have been making up about 35% to 40% of the state’s overall cases in recent months amid the more highly contagious delta variant.

Breakthrough hospitalizations have been accounting for 30% to 35% of current COVID-19 hospitalizations."

https://www.bostonherald.com/2021/11/16/massachusetts-coronavirus-breakthrough-cases-spike-5313-last-week-as-infection-counts-climb-again/

Archive:
https://archive.ph/wip/ORNnM

Spike-Only-Focus-Shitshow-Fest-Collection:
https://threadreaderapp.com/thread/1447787430233481218?refresh=1635109424

"'Original antigenic sin' (OAS): A potential threat beyond the development of booster vaccination VS novel SARS-CoV-2 variants

OAS can trigger immune evasion of the emerging variants in those [.] vaccinated VS former versions of the pathogen."

https://www.cambridge.org/core/journals/infection-control-and-hospital-epidemiology/article/original-antigenic-sin-a-potential-threat-beyond-the-development-of-booster-vaccination-against-novel-sarscov2-variants/C8F4B9BE9E77EB566C71E98553579506

Spike-Only-Focus-Shitshow-Fest-Collection:
https://threadreaderapp.com/thread/1447787430233481218?refresh=1635109424

"The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood–brain barrier"

https://www.sciencedirect.com/science/article/pii/S096999612030406X?via%3Dihub

In Vitro, ... but we find more evidence for the BBB breach:

"Potential adverse events in Japanese women who received tozinameran (BNT162b2, Pfizer-BioNTech)

[.] cerebral venous sinus thrombosis & intracranial hemorrhage (ICH) associated with BNT162b2, Pfizer-BioNTech, [.]"

https://joppp.biomedcentral.com/articles/10.1186/s40545-021-00326-7

"Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination

[.] clinicians should be aware that in some patients, venous or arterial thrombosis can develop at unusual sites such as the brain or abdomen, [.] clinically apparent [.] 5 to 20 days after vaccination."

https://www.nejm.org/doi/full/10.1056/NEJMoa2104840

Ongoing mRNA-Spike-Only-Focus-ShitShow-Fest-Collection:

https://threadreaderapp.com/thread/1447787430233481218?refresh=1637276682

Flashback September 2020:

"SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19

SARS-CoV-2 virus directly activates platelets and potentiates their prothrombotic function and inflammatory response via Spike/ACE2 interactions."

https://jhoonline.biomedcentral.com/articles/10.1186/s13045-020-00954-7

FastForward the Sept2020 Flashback to Mai2021:

"Thrombotic thrombocytopenia associated w/ COVID-19 infection or vaccination: Possible paths to platelet factor 4 autoimmunity

[.] after vaccination with adenoviral vector-based vaccines"

https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1003648

Ongoing mRNA-Spike-Only-Focus-ShitShow-Fest-Collection:

https://threadreaderapp.com/thread/1447787430233481218?refresh=1637276682

Flashback: "SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: Implications for microclot formation in COVID-19

We conclude that the spike protein may have pathological effects directly, without being taken up by cells."

https://www.medrxiv.org/content/10.1101/2021.03.05.21252960v1.full.pdf

"Muuuh S1 only in Deltoid" (Nope)

"[.] (SARS-CoV-2) Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients

[.] detectable levels of S1 antigen in plasma in 11 participants, and spike antigen was detected in 3 of 13 participants."

https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciab465/6279075

Ongoing mRNA-Spike-Only-Focus-ShitShow-Fest-Collection:

https://threadreaderapp.com/thread/1447787430233481218?refresh=1637276682

Topic: "Unexpected Cell Signals via Spike"

"[.] Spike Protein Elicits Cell Signaling in Human Host Cells: Implications for Possible Consequences of COVID-19 Vaccines

[.] consider their long-term consequences carefully, [.] when they are administered to [.] healthy individuals [.]."

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7827936/

"IL-6 Signalling? Nooooo! Muuuuuh!" (Yes)

Flashback Dec 2020:
"[.] spike protein promotes IL-6 trans-signaling by activation of ACE2 receptor signaling in epithelial cells"

https://pubmed.ncbi.nlm.nih.gov/33284859/

"Muuuh IL-6 Signal does nothing Muuuh" (It does)

Flashback 2012: "IL-6 Trans-Signaling via the Soluble IL-6 Receptor: Importance for the Pro-Inflammatory Activities of IL-6"

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3491447/

More Spike/Cell-Signalling:

"SARS-CoV-2 Spike Protein Induces Paracrine Senescence and Leukocyte Adhesion in Endothelial Cells"

https://journals.asm.org/doi/10.1128/JVI.00794-21

Thread:

https://bit.ly/3HxVNxB