"'Original antigenic sin' (OAS): A potential threat beyond the development of booster vaccination VS novel SARS-CoV-2 variants
OAS can trigger immune evasion of the emerging variants in those [.] vaccinated VS former versions of the pathogen."
https://www.cambridge.org/core/journals/infection-control-and-hospital-epidemiology/article/original-antigenic-sin-a-potential-threat-beyond-the-development-of-booster-vaccination-against-novel-sarscov2-variants/C8F4B9BE9E77EB566C71E98553579506
Spike-Only-Focus-Shitshow-Fest-Collection:
https://threadreaderapp.com/thread/1447787430233481218?refresh=1635109424
OAS can trigger immune evasion of the emerging variants in those [.] vaccinated VS former versions of the pathogen."
https://www.cambridge.org/core/journals/infection-control-and-hospital-epidemiology/article/original-antigenic-sin-a-potential-threat-beyond-the-development-of-booster-vaccination-against-novel-sarscov2-variants/C8F4B9BE9E77EB566C71E98553579506
Spike-Only-Focus-Shitshow-Fest-Collection:
https://threadreaderapp.com/thread/1447787430233481218?refresh=1635109424
Now it's time for a political incorrect meme again I found in the chans. I blackfaced the chad to comply to the Twitter-etiquette, I hope that is ok, not?
Spike-Only-Focus-Shitshow-Fest-Collection:
https://threadreaderapp.com/thread/1447787430233481218?refresh=1635109424
Spike-Only-Focus-Shitshow-Fest-Collection:
https://threadreaderapp.com/thread/1447787430233481218?refresh=1635109424
"The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood–brain barrier"
https://www.sciencedirect.com/science/article/pii/S096999612030406X?via%3Dihub
In Vitro, ... but we find more evidence for the BBB breach:
"Potential adverse events in Japanese women who received tozinameran (BNT162b2, Pfizer-BioNTech)
[.] cerebral venous sinus thrombosis & intracranial hemorrhage (ICH) associated with BNT162b2, Pfizer-BioNTech, [.]"
https://joppp.biomedcentral.com/articles/10.1186/s40545-021-00326-7
"Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination
[.] clinicians should be aware that in some patients, venous or arterial thrombosis can develop at unusual sites such as the brain or abdomen, [.] clinically apparent [.] 5 to 20 days after vaccination."
https://www.nejm.org/doi/full/10.1056/NEJMoa2104840
Ongoing mRNA-Spike-Only-Focus-ShitShow-Fest-Collection:
https://threadreaderapp.com/thread/1447787430233481218?refresh=1637276682
https://www.sciencedirect.com/science/article/pii/S096999612030406X?via%3Dihub
In Vitro, ... but we find more evidence for the BBB breach:
"Potential adverse events in Japanese women who received tozinameran (BNT162b2, Pfizer-BioNTech)
[.] cerebral venous sinus thrombosis & intracranial hemorrhage (ICH) associated with BNT162b2, Pfizer-BioNTech, [.]"
https://joppp.biomedcentral.com/articles/10.1186/s40545-021-00326-7
"Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination
[.] clinicians should be aware that in some patients, venous or arterial thrombosis can develop at unusual sites such as the brain or abdomen, [.] clinically apparent [.] 5 to 20 days after vaccination."
https://www.nejm.org/doi/full/10.1056/NEJMoa2104840
Ongoing mRNA-Spike-Only-Focus-ShitShow-Fest-Collection:
https://threadreaderapp.com/thread/1447787430233481218?refresh=1637276682
"'Vaccine-Induced Covid-19 Mimicry' Syndrome: Splice reactions within the SARS-CoV-2 Spike open reading frame result in Spike protein variants that may cause thromboembolic events in patients immunized with vector-based vaccines"
https://www.researchsquare.com/article/rs-558954/v1
More evidence that spike proteins do not stay on the cell membranes but end up circulating in the blood. This study aims to explain the blood clots caused by the J&J and AstraZeneca adenovector vaccines, they claim that the DNA isn't properly spliced and the spike proteins end up in the blood causing thrombosis when the spikes attach to the ACE2 receptors of the endothelial
Ongoing mRNA-Spike-Only-Focus-ShitShow-Fest-Collection:
https://threadreaderapp.com/thread/1447787430233481218?refresh=1637276682
https://www.researchsquare.com/article/rs-558954/v1
More evidence that spike proteins do not stay on the cell membranes but end up circulating in the blood. This study aims to explain the blood clots caused by the J&J and AstraZeneca adenovector vaccines, they claim that the DNA isn't properly spliced and the spike proteins end up in the blood causing thrombosis when the spikes attach to the ACE2 receptors of the endothelial
Ongoing mRNA-Spike-Only-Focus-ShitShow-Fest-Collection:
https://threadreaderapp.com/thread/1447787430233481218?refresh=1637276682
Flashback September 2020:
"SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19
SARS-CoV-2 virus directly activates platelets and potentiates their prothrombotic function and inflammatory response via Spike/ACE2 interactions."
https://jhoonline.biomedcentral.com/articles/10.1186/s13045-020-00954-7
FastForward the Sept2020 Flashback to Mai2021:
"Thrombotic thrombocytopenia associated w/ COVID-19 infection or vaccination: Possible paths to platelet factor 4 autoimmunity
[.] after vaccination with adenoviral vector-based vaccines"
https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1003648
Ongoing mRNA-Spike-Only-Focus-ShitShow-Fest-Collection:
https://threadreaderapp.com/thread/1447787430233481218?refresh=1637276682
"SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19
SARS-CoV-2 virus directly activates platelets and potentiates their prothrombotic function and inflammatory response via Spike/ACE2 interactions."
https://jhoonline.biomedcentral.com/articles/10.1186/s13045-020-00954-7
FastForward the Sept2020 Flashback to Mai2021:
"Thrombotic thrombocytopenia associated w/ COVID-19 infection or vaccination: Possible paths to platelet factor 4 autoimmunity
[.] after vaccination with adenoviral vector-based vaccines"
https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1003648
Ongoing mRNA-Spike-Only-Focus-ShitShow-Fest-Collection:
https://threadreaderapp.com/thread/1447787430233481218?refresh=1637276682
Flashback: "SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: Implications for microclot formation in COVID-19
We conclude that the spike protein may have pathological effects directly, without being taken up by cells."
https://www.medrxiv.org/content/10.1101/2021.03.05.21252960v1.full.pdf
"Muuuh S1 only in Deltoid" (Nope)
"[.] (SARS-CoV-2) Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients
[.] detectable levels of S1 antigen in plasma in 11 participants, and spike antigen was detected in 3 of 13 participants."
https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciab465/6279075
Ongoing mRNA-Spike-Only-Focus-ShitShow-Fest-Collection:
https://threadreaderapp.com/thread/1447787430233481218?refresh=1637276682
We conclude that the spike protein may have pathological effects directly, without being taken up by cells."
https://www.medrxiv.org/content/10.1101/2021.03.05.21252960v1.full.pdf
"Muuuh S1 only in Deltoid" (Nope)
"[.] (SARS-CoV-2) Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients
[.] detectable levels of S1 antigen in plasma in 11 participants, and spike antigen was detected in 3 of 13 participants."
https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciab465/6279075
Ongoing mRNA-Spike-Only-Focus-ShitShow-Fest-Collection:
https://threadreaderapp.com/thread/1447787430233481218?refresh=1637276682
Topic: "Unexpected Cell Signals via Spike"
"[.] Spike Protein Elicits Cell Signaling in Human Host Cells: Implications for Possible Consequences of COVID-19 Vaccines
[.] consider their long-term consequences carefully, [.] when they are administered to [.] healthy individuals [.]."
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7827936/
"IL-6 Signalling? Nooooo! Muuuuuh!" (Yes)
Flashback Dec 2020:
"[.] spike protein promotes IL-6 trans-signaling by activation of ACE2 receptor signaling in epithelial cells"
https://pubmed.ncbi.nlm.nih.gov/33284859/
"Muuuh IL-6 Signal does nothing Muuuh" (It does)
Flashback 2012: "IL-6 Trans-Signaling via the Soluble IL-6 Receptor: Importance for the Pro-Inflammatory Activities of IL-6"
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3491447/
More Spike/Cell-Signalling:
"SARS-CoV-2 Spike Protein Induces Paracrine Senescence and Leukocyte Adhesion in Endothelial Cells"
https://journals.asm.org/doi/10.1128/JVI.00794-21
Thread:
https://bit.ly/3HxVNxB
"[.] Spike Protein Elicits Cell Signaling in Human Host Cells: Implications for Possible Consequences of COVID-19 Vaccines
[.] consider their long-term consequences carefully, [.] when they are administered to [.] healthy individuals [.]."
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7827936/
"IL-6 Signalling? Nooooo! Muuuuuh!" (Yes)
Flashback Dec 2020:
"[.] spike protein promotes IL-6 trans-signaling by activation of ACE2 receptor signaling in epithelial cells"
https://pubmed.ncbi.nlm.nih.gov/33284859/
"Muuuh IL-6 Signal does nothing Muuuh" (It does)
Flashback 2012: "IL-6 Trans-Signaling via the Soluble IL-6 Receptor: Importance for the Pro-Inflammatory Activities of IL-6"
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3491447/
More Spike/Cell-Signalling:
"SARS-CoV-2 Spike Protein Induces Paracrine Senescence and Leukocyte Adhesion in Endothelial Cells"
https://journals.asm.org/doi/10.1128/JVI.00794-21
Thread:
https://bit.ly/3HxVNxB
"Muuuuuuh Stop it Bobby Stop it Muuuuuuuuuuh!" (No)
Have a meme to cheer you up, let's return to happier topics, how about Bio Distribution of LNPs?
LNP 101:
https://www.cas.org/resource/blog/understanding-nanotechnology-covid-19-vaccines
⤍LNP could have targeted ligands (outside), would only transfect muscle cells
⤍Big Pharma designed with PEG polymers (outside) to evade immune system
⤍"PEG reason for LNP throughout body, no targeting ligands ⤍ transfect any cell"
Connected:
https://twitter.com/Bobby_Network/status/1457092712881131527
https://www.pmda.go.jp/drugs/2021/P20210212001/672212000_30300AMX00231_I100_1.pdf
Ongoing mRNA-Spike-Only-Focus-Shit-Show-Collection:
https://threadreaderapp.com/thread/1447787430233481218?refresh=1637276682
Have a meme to cheer you up, let's return to happier topics, how about Bio Distribution of LNPs?
LNP 101:
https://www.cas.org/resource/blog/understanding-nanotechnology-covid-19-vaccines
⤍LNP could have targeted ligands (outside), would only transfect muscle cells
⤍Big Pharma designed with PEG polymers (outside) to evade immune system
⤍"PEG reason for LNP throughout body, no targeting ligands ⤍ transfect any cell"
Connected:
https://twitter.com/Bobby_Network/status/1457092712881131527
https://www.pmda.go.jp/drugs/2021/P20210212001/672212000_30300AMX00231_I100_1.pdf
Ongoing mRNA-Spike-Only-Focus-Shit-Show-Collection:
https://threadreaderapp.com/thread/1447787430233481218?refresh=1637276682
❤1
"Muuuh Stop it, no more LNP-talk, return to Mutational Dynamics of S1 & Evasion" (OK)
"SARS-CoV-2 immune evasion by B.1.427/B.1.429 variant of concern
B.1.427/B.1.429 S variant [.] unusual neutralization escape strategy."
https://www.science.org/doi/full/10.1126/science.abi7994#F4
Connected:
https://twitter.com/Bobby_Network/status/1447799414119088132
https://www.biorxiv.org/content/10.1101/2021.09.11.459844v1
Ongoing mRNA-Spike-Only-Focus-Shit-Show-Collection:
https://threadreaderapp.com/thread/1447787430233481218?refresh=1637276682
"SARS-CoV-2 immune evasion by B.1.427/B.1.429 variant of concern
B.1.427/B.1.429 S variant [.] unusual neutralization escape strategy."
https://www.science.org/doi/full/10.1126/science.abi7994#F4
Connected:
https://twitter.com/Bobby_Network/status/1447799414119088132
https://www.biorxiv.org/content/10.1101/2021.09.11.459844v1
Ongoing mRNA-Spike-Only-Focus-Shit-Show-Collection:
https://threadreaderapp.com/thread/1447787430233481218?refresh=1637276682