Methods in Computational Neuroscience
Course Date: August 2 – August 28, 2020
Deadline: March 16, 2020
Link
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Course Date: August 2 – August 28, 2020
Deadline: March 16, 2020
Link
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#MIT Deep Learning #course, with Alexander Amini, & Ava Soleimany
Link to the course page
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Link to the course page
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MIT Deep Learning 6.S191
MIT's introductory course on deep learning methods and applications
#Microsoft Research Webinar Series
Data Visualization: Bridging the Gap Between Users and Information
Link
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Data Visualization: Bridging the Gap Between Users and Information
Link
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A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns
Abstract
In cancer, the primary tumour’s organ of origin and histopathology are the strongest determinants of its clinical behaviour, but in 3% of cases a patient presents with a metastatic tumour and no obvious primary. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we train a deep learning classifier to predict cancer type based on patterns of somatic passenger mutations detected in whole genome sequencing (WGS) of 2606 tumours representing 24 common cancer types produced by the PCAWG Consortium. Our classifier achieves an accuracy of 91% on held-out tumor samples and 88% and 83% respectively on independent primary and metastatic samples, roughly double the accuracy of trained pathologists when presented with a metastatic tumour without knowledge of the primary. Surprisingly, adding information on driver mutations reduced accuracy. Our results have clinical applicability, underscore how patterns of somatic passenger mutations encode the state of the cell of origin, and can inform future strategies to detect the source of circulating tumour DNA.
Paper
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Abstract
In cancer, the primary tumour’s organ of origin and histopathology are the strongest determinants of its clinical behaviour, but in 3% of cases a patient presents with a metastatic tumour and no obvious primary. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we train a deep learning classifier to predict cancer type based on patterns of somatic passenger mutations detected in whole genome sequencing (WGS) of 2606 tumours representing 24 common cancer types produced by the PCAWG Consortium. Our classifier achieves an accuracy of 91% on held-out tumor samples and 88% and 83% respectively on independent primary and metastatic samples, roughly double the accuracy of trained pathologists when presented with a metastatic tumour without knowledge of the primary. Surprisingly, adding information on driver mutations reduced accuracy. Our results have clinical applicability, underscore how patterns of somatic passenger mutations encode the state of the cell of origin, and can inform future strategies to detect the source of circulating tumour DNA.
Paper
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Nature
A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns
Nature Communications - Some cancer patients first present with metastases where the location of the primary is unidentified; these are difficult to treat. In this study, using machine learning,...
ZeRO & DeepSpeed: New system optimizations enable training models with over 100 billion parameters
Link
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Link
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Microsoft Research
ZeRO & DeepSpeed: New system optimizations enable training models with over 100 billion parameters - Microsoft Research
The latest trend in AI is that larger natural language models provide better accuracy; however, larger models are difficult to train because of cost, time, and ease of code integration. Microsoft is releasing an open-source library called DeepSpeed, which…
AI on steroids: Much bigger neural nets to come with new hardware, say Bengio, Hinton, and LeCun
Link
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Link
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ZDNet
AI on steroids: Much bigger neural nets to come with new hardware, say Bengio, Hinton, and LeCun
Novel hardware to accelerate training and inference of neural nets can lead to much larger models, perhaps someday making possible the trillion-synapse neural net, say deep learning creators Geoffrey Hinton, Yoshua Bengio, and Yann LeCun. Also important is…
Two nice tools for drawing deep nets for your papers/presentations:
alexlenail
PlotNeuralNet
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alexlenail
PlotNeuralNet
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GitHub
GitHub - HarisIqbal88/PlotNeuralNet: Latex code for making neural networks diagrams
Latex code for making neural networks diagrams. Contribute to HarisIqbal88/PlotNeuralNet development by creating an account on GitHub.
Complete Statistical Theory of Learning (Vladimir #Vapnik) | MIT Deep Learning Series
YouTube
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YouTube
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YouTube
Complete Statistical Theory of Learning (Vladimir Vapnik) | MIT Deep Learning Series
Lecture by Vladimir Vapnik in January 2020, part of the MIT Deep Learning Lecture Series.
Slides: http://bit.ly/2ORVofC
Associated podcast conversation: https://www.youtube.com/watch?v=bQa7hpUpMzM
Series website: https://deeplearning.mit.edu
Playlist: ht…
Slides: http://bit.ly/2ORVofC
Associated podcast conversation: https://www.youtube.com/watch?v=bQa7hpUpMzM
Series website: https://deeplearning.mit.edu
Playlist: ht…
#Position
Dear all,
Vivacity Labs, a fast-growing startup in London, is looking for a Machine Learning Researcher to work on using Reinforcement Learning for Traffic Signal Control. You would have extensive simulations & existing datasets to work with, and would be deploying your technology to live junctions in the UK from day 1.
For more details, please see:
https://angel.co/company/vivacity-labs/jobs/664275-machine-learning-researcher
Please feel free to apply directly to joinus@vivacitylabs.com with a CV and covering note.
Kind regards,
Mark
🔭 @DeepGravity
Dear all,
Vivacity Labs, a fast-growing startup in London, is looking for a Machine Learning Researcher to work on using Reinforcement Learning for Traffic Signal Control. You would have extensive simulations & existing datasets to work with, and would be deploying your technology to live junctions in the UK from day 1.
For more details, please see:
https://angel.co/company/vivacity-labs/jobs/664275-machine-learning-researcher
Please feel free to apply directly to joinus@vivacitylabs.com with a CV and covering note.
Kind regards,
Mark
🔭 @DeepGravity