3 Years ago I spent 28 hours on the bus and then 16 on a boat through the Amazon ( there was an airplane option actually, but I never chose easy way 😁 ) to talk to shamans and ask them what do they think about all the tech innovation happening now from genetic modifications to AI and ofcause their experience with Auhuasca. It was fun to watch it again, thanks to Google memories. Just wanted share his face when I've asked him about his first time 😍

Experts debate the risks of made-to-order DNA – Ars Technica
https://arstechnica.com/science/2022/12/experts-debate-the-risks-of-made-to-order-dna/amp/

SBF was prescribed for Adderall (Stimulant) and Emsam Patch (MAOI) And am not a super expert, but this is a fucking bad combo its at least dangerous and sometimes deadly according to Psychonautwiki and a few other sources, I don't know how long he used it he literally destroyed his dopamine system and now everything is more clear to me ;) https://slate.com/technology/2022/12/sam-bankman-fried-ftx-emsam-patch-testimony-arrested.html

Human Brain Organoids Implanted Into Mouse Cortex Respond to Visual Stimuli for First Time - Neuroscience News

So, it seem that we have a great tool now to perform tests 😁

" This experimental setup opens up unprecedented opportunities for investigations of human neural network-level dysfunctions underlying developmental brain diseases,” said Kuzum. "

https://neurosciencenews.com/organoid-transplant-visual-stimuli-22149/

The death of SynthBio companies and my other predictions for Biotech in 2023

Josiah knows this shit like no one else.

https://amateurgods.substack.com/p/the-death-of-synthbio-companies-and

ChatGPT and AI language tools banned by AI conference for writing papers - The Verge

"The conferences who will enforce such rules will be the biggest losers for 2023."

https://www.theverge.com/2023/1/5/23540291/chatgpt-ai-writing-tool-banned-writing-academic-icml-paper

Psychodelics in on of the top 5 topics for 2023 by Economist.

MDMA, Psylocybin and Ketamine Will most likely be approved for medical use in US and UK

https://www.youtube.com/watch?v=nv3iOH_XYdo

Kids' Incredible Learning May All Be Down to 1 Chemical in The Brain : ScienceAlert

TLDR:GABA

https://www.sciencealert.com/kids-incredible-learning-may-all-be-down-to-1-chemical-in-the-brain

Company Using ChatGPT for Mental Health Support Raises Ethical Issues


If there is a chance that someone fill finally define what is Ethical ?

https://www.businessinsider.com/company-using-chatgpt-mental-health-support-ethical-issues-2023-1

Scientists create new category of non-alcoholic ‘spirit’ - The Spirits Business

Because during alcohol in 2023 is like riding a horse to get to the office ( first of all I'm joking at myself 😂)

Let's drink GABA and be fast learners as kids ( I mean an article 2 publications ago )

https://www.thespiritsbusiness.com/2023/01/scientists-create-new-category-of-non-alcoholic-spirit/

Usually we see examples of either optical illusions. (you name it) or textual ( Like if you can still read words when symbols in deffirnet order ). This image is a nice example of one type of input affect how we process the other one. (At least for some people). More in the comments.

TLDR:

Pince Harry took Ayahuasca

He said: “After taking ayahuasca with the proper people... I suddenly realised – wow! – it’s not about the crying. She [Diana] wants me to be happy. So this weight off my chest was not the need to cry, it was the acceptance and realisation that she has gone, but that she wants me to be happy and that she’s very much present in my life".

( Quote from the other sources)

https://www.nytimes.com/2023/01/10/well/psychedelics-grief-mental-health.html

(relatively) New book and seems to be super exciting.


Reality Switch Technologies: Psychedelics as Tools for the Discovery and Exploration of New Worlds


" In 2015, he collaborated with DMT pioneer Dr. Rick Strassman to develop a model for the repurposing of the target-controlled intravenous infusion technology used in anaesthesiology to allow the DMT state to be safely and stably extended for an indefinite period of time. It is hoped that this technology will be used to allow extended sojourns in the DMT space for detailed exploration and mapping of the space, as well as for performing experiments and establishing communication with contacted intelligences."

Holyfuckigshit tht's exactly what I'm planning.

https://www.amazon.com/dp/1739110102

Humans are overvalued 😆😆😆

Meet the podcast with ChatGPT.

It's not just a podcast it's a podcast led by Reid Hoffman (PayPal/LinkedIn/Greylock)

https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5zb3VuZGNsb3VkLmNvbS91c2Vycy9zb3VuZGNsb3VkOnVzZXJzOjIwNTMyMzI1NC9zb3VuZHMucnNz/episode/dGFnOnNvdW5kY2xvdWQsMjAxMDp0cmFja3MvMTQyMTc4NTkyNA?ep=14

The changes in the way we work will be massive. The only way people will be able to outperform AI is through imagination. The use of Psychedelics will probably be the only option to compete. There is no way we will be able to do it without it. It's not the question of IF anymore. It's When. I just realized that Proposal 122 ( decriminalization of multiple Psychedelics including DMT ) and the release of ChatGPT both happened almost at the same time in late November 2022. Remember this date. This is fucking huge.

DMTx

it's going to be massive

"The DMTx extended peak would be five times stronger than Ayahuasca and can theoretically last many hours.  The acceleration of the entry, the intensity of the peak, and the duration of the DMT experience can literally be programed, or “dialed-in,” even adjusted during the experience, for different therapeutic, advanced problem solving, and consciousness explorations experiences. It can be quickly “turned off” if any safety concerns become apparent, therefore it is unlike any psychedelic experience previously possible."

https://www.dmtx.org/

3D Organoid Models Show Brain Mechanisms of Tourette Syndrome - Neuroscience News

I want to play with brain organoids, just curious how complex is is for a home-lab in a "backyard/kitchen" 😆

https://neurosciencenews.com/tourette-brain-organoid-22281/

Psychedelic-Assisted Therapy 101

===== Momentum (Why?)

> Triggers:

1. Rick Dubin’s FDA 3rd-stage MDMA
2. Relatively successful Cannabis history and results
3. Increased practical experience in Mexican/Peruvian/African rituals
4. Post-pandemic growth in mental issues

> As a result:

New trails
Hundreds of research papers
TED talks
Popular Books ( How to Change Mind)
Documentaries ( Netflix How to Change Mind )
Media and Celebs ( Mike Tyson, Joe Rogan, Prince Harry, Oxxymiron)
Legalization/Decriminalization(Oregon, Colorado)


===== Simplified mechanism and applications (What)

Think of it as surgery for the brain, we need it sometimes to fix issues that we can’t fix other way

Mechanism (simplified): Serotonin 5ht2-A receptor

As a result:

- default mode network ( where all concepts are stored, the more we take psychedelics more concepts will be temporarily deleted; if we turn it off completely, we will feel Ego dissolution)
- mental flexibility (psychological and cognitive [Like you are stuck in a negative pattern and now can understand it and move further ].
- neuroplasticity (reorganize structure, Form new connections, increase the capacity of change) [as a result, you can rewrite some patterns ]

Analog: Disassembler for a brain


Current applications:


Phase 3 or a lot of anecdotal or historical evidence

- depression ( Psilocybin, Ketamine, Ayahuasca)
- end of life and goals, terminal sickness (DMT, Psilocybin
- PTSD trauma (MDMA)
- use disorder (Ayahuasca, Psilocybin
- anxeety (MDMA , Psylcybin)

Phase 2

- chronic pain ( Psylocybin)
- eating disorder ( MDMA)
-ADHD ( LSD-like)
-cluster headache, migraine ( LSD-like)

Phase 1

- Alzimers ( LSD -like )
- Autism ( MDMA- like )
- OCD ( Psylocybin- like )



===== Who ( Experts and Evangelists)


All of them are valuable sources: Shamans, Psychonauts, Neuroscientists, Psychologists.

Popular people:

MDMA - Rick Doblin, Alex Shulgin
Psylocybin - Paul Stemets
DMT - Rick Strassman, McKenna
LSD - Timothy Leary, Ram Dass
All- Hamilton Morris (Hamiltons Pharmacopeia)

Organizations:

MAPS
Johns Hopkins University
ThirdWave


====== Super Short History (When )

1. First wave

Shamans, berserks, woodo, etc…..

2. Second Wave

1960-70 Mushrooms in USA + LSD


3. Third Wave

2006 - Johns Hopkins Psilocybin research no harm
2010 - MAPS first clinical trial of MDMA Therapy 73% cured
2010-2020 100 clinical trials of Psilocybin / MDMA /LSD
2017 - FDA for MDMA - Breakthrough Status
2019 - FDA for Psilocybin - Breakthrough Status


====== Legal options (Where)

USA:
Oregon ( from 2020 Legal Psilocybin )
Denver, Colorado (Nov 30 2022, Proposition 122, Psilocybin, Ibogaine, DMT, Mescaline )
California ( Dec 16 2022, SB 58, Psilocybin, Ibogaine, DMT, Mescaline)


Canada ( Psilocybin)
Amsterdam ( Psilocybin, Some MDMA-like)
Peru ( Ayahuasca, Mescaline )
Mexico ( Mescaline)
Bali/Gili (Psilocybin?)
Google for more


====== Process ( How )

Set setting size

Yes:
- Mental issues proved by a doctor after unsuccessful results with regular drugs (Antidepressants, etc)

No:
- kids
- sickness ( Bipolar, Schizophrenia, Neyroticasm)
- Currently on meds (SSRI, etc)

Options:

1. Microdoses, very popular as start (Psylocibin, LSD)
2. Normal dose, usually used (Anything)
3. Heroic Dose, mostly for complex issues ( DMT, Psilocybin )

Process:

1. Prepare/plan ( Prepare as you go on a long vacation to Alaska)
-personal traits ( do you like more music /less music)
- intention!!!!!! ( set some goals)
- set (relaxed, curious, healthy, rested)
2. Use
- sitter (experienced)
- supplies (water etc..)
- setting ( environment)
3. Integration
- distill insights the next day
- support behavior next 2-6 months


====== Future

Ongoing research:

- better setting ( special music)
- new legal molecules ( CMPS Psilocybin analogs)
- trip stoppers ( change the duration of the trip)
- VR-assisted ( for inducing a particular effect or preparing)
- nun-hallucinogenic compounds ( who are scared of hallucinations)
- DMT worlds mappings and exploration (WTF are those entities)

2023 Starts With Psychedelic Decrim Measures In Several States.


Washington, Illinois, Virginia... Who is next?


https://microdose.buzz/news/2023-starts-with-psychedelic-decrim-measures-in-several-states/

New Nanoparticles Deliver Therapy Brain-Wide and Edit Alzheimer’s Gene - Neuroscience News

Researchers have developed a new family of nano-scale capsules capable of carrying CRISPR gene editing tools to different organs of the body before harmlessly dissolving. The capsules were able to enter the brains of mice and successfully edit a gene associated with Alzheimer’s disease.


https://neurosciencenews.com/nanoparticle-crispr-alzheimers-22306/

Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms | Pharmacological Review

Looks like the most comprehensive list of effects on all neurotransmitters.

https://pharmrev.aspetjournals.org/content/73/1/202