Old, but interesting example what AI might "see" before death.

It might bring some thoughts on what people actually see before death or during death-like experience.




https://vimeo.com/340318187

Human Brain Organoids Respond to Visual Stimuli When Transplanted Into Adult Rats - Neuroscience News
We saw that a good number of neurons within the organoid responded to specific orientations of light, which gives us evidence that these organoid neurons were able to not just integrate with the visual system, but they were able to adopt very specific functions of the visual cortex.”


https://neurosciencenews.com/organoid-transplant-visual-stimuli-22436/

Australia to allow prenoscription of MDMA and psilocybin for treatment-resistant mental illnesses | Health | The Guardian

Woot!!! One more Country 🔥

"The drugs will only be allowed to be used in a very limited way, and remain otherwise prohibited, but the move was described as a “very welcome step away from what has been decades of demonisation”


https://www.theguardian.com/australia-news/2023/feb/03/australia-to-allow-prenoscription-of-mdma-and-psilocybin-for-treatment-resistant-mental-illnesses

MDMA and Psilocybin Are Approved as Medicines for the First Time | WIRED


Again, this is really important. Since I recently compared the release of ChatGPT and Proposition 122 in Colorado for decriminalization as A-ha moments. Now I'll tell you that Australia announcement for MDMA and Psylocybin approval in response to USA legalization efforts is like Google's investment in Anthropic ( OpenAI rival) in response to Microsoft deal with OpenAI happened yesterday.


Australia will likely impact whether other countries choose to offer the drugs for therapeutic purposes in the future—and that includes if it goes wrong and people get harmed. “I think the eyes of the world will be watching Australia now -


https://www.wired.com/story/australia-psilocybin-mdma-approval/

A Revolutionary New Physics Hypothesis: Three Time Dimensions, One Space Dimension

Because Why not🔥

We discussed that multiple time dimensions are possible in some early podcast episode.🥳


https://scitechdaily.com/a-revolutionary-new-physics-hypothesis-three-time-dimensions-one-space-dimension/

Can psychedelic drugs boost work performance and well-being?

"Psychedelics can also solve for frequent workplace issues, like:

Low energy or passion for work
Imposter syndrome
Stress, burnout, and moral injury
Perfectionism
Self-awareness
Procrastination"

What's interesting is that as you can see they are not boosting something but rather solving some issue that prevents us doing what we should do.


https://qz.com/emails/quartz-at-work/1850056436/can-psychedelic-drugs-boost-work-performance-and-well-b

So, briefly saying, their pitch deck was "Like Ayahuasca but without vomiting". Poor Peru, their tourist income will drop significantly 😂

Terran Biosciences announces publication of PCT patent applications covering orally active forms of DMT and 5-MeO-DMT and long-acting MDMA



DMT has traditionally been taken in combination with a monoamine oxidase (MAO) inhibitor to help reduce this metabolic breakdown, however, this approach is difficult to translate to widespread clinical use as it can be associated with side effects such as nausea, vomiting, and changes in blood pressure.
Terran's unique prodrugs are novel compounds that are designed to be given as a single oral dose, avoid first pass metabolism, and then breakdown in order to release high levels of the original active molecule in the brain




https://www.prnewswire.com/news-releases/terran-biosciences-announces-publication-of-pct-patent-applications-covering-orally-active-forms-of-dmt-and-5-meo-dmt-and-long-acting-mdma-301738126.html

Great TLDR from recently released book.

REALITY SWITCH TECHNOLOGIES
Psychedelics as Tools for the Discovery and Exploration of New Worlds

🔥🔥🔥


https://grahamhancock.com/gallimorea2/

Pro: Found a simple Brain map.
Con: It's a bit complicated.

https://thehighestofthemountains.com/brainmaps.html

Receptor Location Matters for Psychedelic Drug Effects - Neuroscience News

There are so many things to discover 🤩

"Olson and colleagues experimented with chemically tweaking drugs and using transporters to make it easier or harder for compounds to slip across cell membranes. Serotonin itself is polar, meaning it dissolves well in water but does not easily cross the lipid membranes that surround cells. The psychedelics, on the other hand, are much less polar and can easily enter the interior of a cell"



https://neurosciencenews.com/psychedelics-serotonin-neurons-22516/

Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors | Science

One more time about this recent research.

So theoretically now we can separate neuroplasticity effect and serotonin activation effects of Psychodelics.

https://www.science.org/doi/10.1126/science.adf0435

ChatGPT Is a Blurry JPEG of the Web | The New Yorker


I'm more and more into idea that ChatGPT is like human on shrooms, much more creative and at the same time not capable of making simple tasks. It's like my first experience with shrooms, when you suddenly understand the whole world in it's multiple dimensions but can't concentrate to write a single word on mobile phone about any insight let alone simply remember where is your phone and how to write 😅


https://www.newyorker.com/tech/annals-of-technology/chatgpt-is-a-blurry-jpeg-of-the-web

With Aera, CRISPR pioneer Feng Zhang goes after gene therapy’s delivery problem | BioPharma Dive


Cracking the code for delivery may also lead to new targets, perhaps in the central nervous system, heart or lungs, Akinc said. And it could also help with some of the problems associated with manufacturing the complex medicines.

https://www.biopharmadive.com/news/feng-zhang-aera-gene-therapy-alnylam/642901/

Lipophilicity helps explain psychedelic drugs’ therapeutic effects | Research | Chemistry World

One more article about the recent research on internal serotonin receptors activated by Psychodelics👌

"He suggests that an ‘obvious candidate’ would be endogenous psychedelics. These are psychedelic drug-like compounds, like DMT, that are produced naturally in mammals, and whose purpose remains something of a mystery. According to Olson, it’s possible that these molecules might play a more important biological role than is currently realised."

https://www.chemistryworld.com/news/lipophilicity-helps-explain-psychedelic-drugs-therapeutic-effects/4017016.article