A Revolutionary New Physics Hypothesis: Three Time Dimensions, One Space Dimension

Because Why not🔥

We discussed that multiple time dimensions are possible in some early podcast episode.🥳


https://scitechdaily.com/a-revolutionary-new-physics-hypothesis-three-time-dimensions-one-space-dimension/

Can psychedelic drugs boost work performance and well-being?

"Psychedelics can also solve for frequent workplace issues, like:

Low energy or passion for work
Imposter syndrome
Stress, burnout, and moral injury
Perfectionism
Self-awareness
Procrastination"

What's interesting is that as you can see they are not boosting something but rather solving some issue that prevents us doing what we should do.


https://qz.com/emails/quartz-at-work/1850056436/can-psychedelic-drugs-boost-work-performance-and-well-b

So, briefly saying, their pitch deck was "Like Ayahuasca but without vomiting". Poor Peru, their tourist income will drop significantly 😂

Terran Biosciences announces publication of PCT patent applications covering orally active forms of DMT and 5-MeO-DMT and long-acting MDMA



DMT has traditionally been taken in combination with a monoamine oxidase (MAO) inhibitor to help reduce this metabolic breakdown, however, this approach is difficult to translate to widespread clinical use as it can be associated with side effects such as nausea, vomiting, and changes in blood pressure.
Terran's unique prodrugs are novel compounds that are designed to be given as a single oral dose, avoid first pass metabolism, and then breakdown in order to release high levels of the original active molecule in the brain




https://www.prnewswire.com/news-releases/terran-biosciences-announces-publication-of-pct-patent-applications-covering-orally-active-forms-of-dmt-and-5-meo-dmt-and-long-acting-mdma-301738126.html

Great TLDR from recently released book.

REALITY SWITCH TECHNOLOGIES
Psychedelics as Tools for the Discovery and Exploration of New Worlds

🔥🔥🔥


https://grahamhancock.com/gallimorea2/

Pro: Found a simple Brain map.
Con: It's a bit complicated.

https://thehighestofthemountains.com/brainmaps.html

Receptor Location Matters for Psychedelic Drug Effects - Neuroscience News

There are so many things to discover 🤩

"Olson and colleagues experimented with chemically tweaking drugs and using transporters to make it easier or harder for compounds to slip across cell membranes. Serotonin itself is polar, meaning it dissolves well in water but does not easily cross the lipid membranes that surround cells. The psychedelics, on the other hand, are much less polar and can easily enter the interior of a cell"



https://neurosciencenews.com/psychedelics-serotonin-neurons-22516/

Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors | Science

One more time about this recent research.

So theoretically now we can separate neuroplasticity effect and serotonin activation effects of Psychodelics.

https://www.science.org/doi/10.1126/science.adf0435

ChatGPT Is a Blurry JPEG of the Web | The New Yorker


I'm more and more into idea that ChatGPT is like human on shrooms, much more creative and at the same time not capable of making simple tasks. It's like my first experience with shrooms, when you suddenly understand the whole world in it's multiple dimensions but can't concentrate to write a single word on mobile phone about any insight let alone simply remember where is your phone and how to write 😅


https://www.newyorker.com/tech/annals-of-technology/chatgpt-is-a-blurry-jpeg-of-the-web

With Aera, CRISPR pioneer Feng Zhang goes after gene therapy’s delivery problem | BioPharma Dive


Cracking the code for delivery may also lead to new targets, perhaps in the central nervous system, heart or lungs, Akinc said. And it could also help with some of the problems associated with manufacturing the complex medicines.

https://www.biopharmadive.com/news/feng-zhang-aera-gene-therapy-alnylam/642901/

Lipophilicity helps explain psychedelic drugs’ therapeutic effects | Research | Chemistry World

One more article about the recent research on internal serotonin receptors activated by Psychodelics👌

"He suggests that an ‘obvious candidate’ would be endogenous psychedelics. These are psychedelic drug-like compounds, like DMT, that are produced naturally in mammals, and whose purpose remains something of a mystery. According to Olson, it’s possible that these molecules might play a more important biological role than is currently realised."

https://www.chemistryworld.com/news/lipophilicity-helps-explain-psychedelic-drugs-therapeutic-effects/4017016.article

Is it already overhyped😂⁉️

https://youtu.be/a546lxxJIhE

The idea that ChatGPT is simply “predicting” the next word is, at best, misleading - LessWrong

Finally someone described it nicely

"I am reminded, moreover, of the late Walter Freeman’s conception of consciousness as arising through discontinuous whole-hemisphere states of coherence succeeding one another at a “frame rate” of 6 Hz to 10Hz – something I discuss in “Ayahuasca Variations” (2003). It’s the whole hemisphere aspect that’s striking (and somewhat mysterious) given the complex connectivity across many scales and the relatively slow speed of neural conduction."


https://www.lesswrong.com/posts/sbaQv8zmRncpmLNKv/the-idea-that-chatgpt-is-simply-predicting-the-next-word-is

Important insight, they launched worldwide Psychodelics FMRI data sharing project 👌




https://podcasts.google.com/feed/aHR0cHM6Ly9wbGFudG1lZGljaW5lcG9kY2FzdC5saWJzeW4uY29tL3Jzcw/episode/OGNlMTllYTAtNTc2ZC00NWRmLTgxZmEtZmI1OGI3NzkyOGEx?ep=14

Join Studies — psynautics.

Self - funded microdosing study. Pay 40$, get Muse + instructions, track your EEG during microdosing experience and share the data.

Like 23andMe but for brain on Shrooms.
Awesome. 👍


https://www.psynautics.com/join-studies

Scientists target ‘biocomputing’ breakthrough with use of human brain cells | Financial Times


Yeahs, that's what I want at the end 🤡

"Researchers are also developing technologies to link organoids together and communicate with them, sending them information and decoding their “thoughts”. Hartung’s lab has tested an interface, “a flexible shell that is densely covered with tiny electrodes that can both pick up signals from the organoid and transmit signals to it"


https://www.ft.com/content/9f51a30d-eedc-446a-8a5c-d2997c670c65

Suppressing Symptoms – A Neuro-Chip To Manage Brain Disorders


"NeuralTree functions by extracting neural biomarkers – patterns of electrical signals known to be associated with certain neurological disorders – from brain waves. It then classifies the signals and indicates whether they herald an impending epileptic seizure or Parkinsonian tremor, for example. If a symptom is detected, a neurostimulator – also located on the chip – is activated, sending an electrical pulse to block it."


https://scitechdaily.com/suppressing-symptoms-a-neuro-chip-to-manage-brain-disorders/

Scientists Now Want to Create AI Using Real Human Brain Cells.

Yesterday's article without a paywal. Amazing shit. Where is my lab with brain organoids processing my chatGPT's and Dalle's which building VR games where all the real people spend their time to generate more data to feed my brain organoids 🤡?

https://www.vice.com/en/article/qjkgap/scientists-now-want-to-create-ai-using-real-human-brain-cells

A number of really interesting concepts.

I liked the story when a person had 13 personalities and one of them was allergies to oranges and the other was not. So guess what, he may not experience allergy being one personality but when he changed his personality while drinking orange juice he experienced allergy. WTF. 😅

https://youtu.be/t2k5HDyGzYc

I decided to play a bit with the recent AI and created this educational fairy-tale anime for kids about Psychedelics.

What do you think?😅

A look inside the lab building mushroom computers | Popular Science


"And it’s definitely an idea that has gained ground recently, as seen through experimental biology-based algorithms and prototypes of microbe sensors and kombucha circuit boards."

https://www.popsci.com/technology/unconventional-computing-lab-mushroom/