Next-level CRISPR gene editing: No viruses required
“Basically, what we’ve done is taken this template DNA and damaged it,” said Chris Richardson, corresponding author of the study. “We’ve in fact damaged it in the most severe way I can think of. And the cell doesn’t say, ‘Hey, this is junk; let me throw it away.’ What the cell actually says is, ‘Hey, this looks great; let me stick it into my genome.’”
https://newatlas.com/biology/nonviral-method-increases-gene-editing-efficiency-threefold/
“Basically, what we’ve done is taken this template DNA and damaged it,” said Chris Richardson, corresponding author of the study. “We’ve in fact damaged it in the most severe way I can think of. And the cell doesn’t say, ‘Hey, this is junk; let me throw it away.’ What the cell actually says is, ‘Hey, this looks great; let me stick it into my genome.’”
https://newatlas.com/biology/nonviral-method-increases-gene-editing-efficiency-threefold/
New Atlas
Next-level CRISPR gene editing: No viruses required
Modified viruses have proven a handy way to get CRISPR/Cas9 gene editing materials into the nucleus of cells – but they're expensive, difficult to scale and potentially toxic. Now, researchers have found a non-viral approach that does the job better.
Mushrooms Appear to Have Electrical 'Conversations' After It Rains
https://www.sciencealert.com/mushrooms-appear-to-have-electrical-conversations-after-it-rains
https://www.sciencealert.com/mushrooms-appear-to-have-electrical-conversations-after-it-rains
ScienceAlert
Mushrooms Appear to Have Electrical 'Conversations' After It Rains
What are they saying?
Forwarded from AI Vibe Coding, Context Engineering, Prompt Engineering
Asimov Unknowingly Pioneered Modern Prompt Engineering | HackerNoon
https://hackernoon.com/asimov-unknowingly-pioneered-modern-prompt-engineering
https://hackernoon.com/asimov-unknowingly-pioneered-modern-prompt-engineering
Hackernoon
Asimov Unknowingly Pioneered Modern Prompt Engineering
Isaac Asimov, a visionary in the realm of science fiction, unknowingly pioneered modern prompt engineering through his thought-provoking robot series.
Psychedelics for Mental Health | Psychedelics Today
Great easy-to-use FAQ for most common Psychedelics with links to corresponding research papers.
Skill level #novice
https://psychedelicstoday.com/psychedelics-for-mental-health/
Great easy-to-use FAQ for most common Psychedelics with links to corresponding research papers.
Skill level #novice
https://psychedelicstoday.com/psychedelics-for-mental-health/
Psychedelics Today
Psychedelics for Mental Health | Psychedelics Today
Check out all the resources for the Psychedelics For Mental Health series you see on our social media channels, as part of Mental Health Awareness Month: Psilocybin for Depression and Anxiety 🍄 LSD for Anxiety, Depression, Substance Abuse, and More 🌈 MDMA…
MIT scientists find something alarming about artificial intelligence
https://www.msn.com/en-us/news/technology/mit-scientists-find-something-alarming-about-artificial-intelligence/ar-AA1b17Vu
https://www.msn.com/en-us/news/technology/mit-scientists-find-something-alarming-about-artificial-intelligence/ar-AA1b17Vu
MSN
MIT scientists find something alarming about artificial intelligence
An MIT study looked at how AI would judge perceived breaches of a code. The post MIT scientists find something alarming about artificial intelligence appeared first on Talker.
Researchers Are Mapping DMT Dimensions Through DMTx Tech
Seems like DMTX is finally started and we will see more exciting news from various labs all over the world.
Any friends anesthesiologists?😁
"But that doesn’t mean we can’t have some kind of mapping. One can think about Level mapping for example, so do different levels of intensity experience reliably take you to different types of spaces? Is there a progression? I mean people talk already, about you know, moving to the waiting room and then the dome. There has already been developed in a very informal sense, a certain kind of mapping of the space.”
Skill level #intermediate
https://psychedelicspotlight.com/researchers-are-mapping-out-new-dimensions-through-dmtx-technology/
Seems like DMTX is finally started and we will see more exciting news from various labs all over the world.
Any friends anesthesiologists?😁
"But that doesn’t mean we can’t have some kind of mapping. One can think about Level mapping for example, so do different levels of intensity experience reliably take you to different types of spaces? Is there a progression? I mean people talk already, about you know, moving to the waiting room and then the dome. There has already been developed in a very informal sense, a certain kind of mapping of the space.”
Skill level #intermediate
https://psychedelicspotlight.com/researchers-are-mapping-out-new-dimensions-through-dmtx-technology/
Psychedelic Spotlight
Researchers Are Mapping Out New Dimensions Through DMTx Technology
Researchers are looking into mapping DMT dimensions by using DMTx technology also known as Extended State DMT.
😱1
Human brain effects of DMT assessed via EEG-fMRI | PNAS
https://www.pnas.org/doi/10.1073/pnas.2218949120
Skill level #expert
https://www.pnas.org/doi/10.1073/pnas.2218949120
Skill level #expert
PNAS
Human brain effects of DMT assessed via EEG-fMRI
Psychedelics have attracted medical interest, but their effects on human brain function are incompletely understood. In a comprehensive, within-sub...
https://www.technologynetworks.com/tn/news/fast-and-effective-method-to-genetically-modify-brain-organoids-developed-373432
Until now, these procedures were sometimes very labor-intensive and took several months. The team of researchers led by Michael Heide has now developed a method that allows brain organoids to be genetically manipulated quickly and cost-effectively.
"We use microinjection and electroporation for our method," Heide explains. "In this process, genetic material is injected into the organoids with a very thin cannula and introduced into the cells with the help of a small electrical pulse. It takes only a few minutes, and the brain organoids can be analyzed after a few days
Until now, these procedures were sometimes very labor-intensive and took several months. The team of researchers led by Michael Heide has now developed a method that allows brain organoids to be genetically manipulated quickly and cost-effectively.
"We use microinjection and electroporation for our method," Heide explains. "In this process, genetic material is injected into the organoids with a very thin cannula and introduced into the cells with the help of a small electrical pulse. It takes only a few minutes, and the brain organoids can be analyzed after a few days
Technology Networks
Fast and Effective Method to Genetically Modify Brain Organoids Developed
Researchers have now succeeded in genetically manipulating brain organoids in only a few days instead of the usual several months.
Researchers treat depression by reversing brain signals traveling the wrong way | News Center | Stanford Medicine
Finally 😁
The findings also suggest that backward streams of neural activity between key areas of the brain could be used as a biomarker to help diagnose depression.
https://med.stanford.edu/news/all-news/2023/05/depression-reverse-brain-signals.html
Finally 😁
The findings also suggest that backward streams of neural activity between key areas of the brain could be used as a biomarker to help diagnose depression.
https://med.stanford.edu/news/all-news/2023/05/depression-reverse-brain-signals.html
News Center
Researchers treat depression by reversing brain signals traveling the wrong way
A new study led by Stanford Medicine researchers is the first to reveal how magnetic stimulation treats severe depression: by correcting the abnormal flow of brain signals.
Holy shit, I guess I need to change my pllans for summer 🙃🤔🤪?
🌚3🔥1
https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5saWJzeW4uY29tLzgxODk1L3Jzcw/episode/NjgxMmNkZTUtYThmZi00OWIxLThkMmMtZGU5NGM4MDQ2YjRl?ep=14
Why MDMA analogs?
1. Safer options for mory risky categories of people:
People with Cardiac deseas history
People over the age of 65
2. Other medical application apart form PTD
Social anxiety for Autism
Parkinson's desease
3. Other impoovements
Shorter therapy duration
More cheaper production
Skill level: #intermediate
Why MDMA analogs?
1. Safer options for mory risky categories of people:
People with Cardiac deseas history
People over the age of 65
2. Other medical application apart form PTD
Social anxiety for Autism
Parkinson's desease
3. Other impoovements
Shorter therapy duration
More cheaper production
Skill level: #intermediate
Google Podcasts
Psychedelics Today - PT410 – Nick Kadysh – Manufacturing MDMA and Why Creating MDMA Analogs Is So Important
In this episode, Joe interviews Nick Kadysh: Founder and CEO of PharmAla Biotech and member of the board of directors for The Canadian Psychedelic Businesses Association.
PharmAla Biotech is a Toronto-based Life Sciences company with two focuses: contracting…
PharmAla Biotech is a Toronto-based Life Sciences company with two focuses: contracting…
New Psychedelics compounds search.
Why?
Deal with First gen psychedelic issues:
- they were not created specifically to threat a particular disorder even if can do it with a certain efficacy
- they have cardiotoxicity related to 5ht2b mechanism
- long action duration length for therapy
New hopes and ideas:
- decouple halucenogetic from therapeutic effect
- potentially reaching even newer states of mind
- targetly engineered experience without so complex set and setting
What?
- Kanna alcaloids for premature ejaculation 😅
- BPL-003 for Treatment Resistant Depression (TRD).
- IHCH-7113 Non halucenogetic psychedelic for depression
- Ele-101 for depression and Alcohol Use Disorder (AUD).
How?
1. AI assisted search
- Predictive AI. Train on structure to properties (need big dataset of both)
- Generative AI. Evolutionary machines
2. Natural compounds search and enchantment
- Research existing less popular natural compounds rom indigenous communities
- Enchance properties (Increase a half life, change blood barrier penetration, etc..
3. Future approaches
- computational chemistry (compounds VS receptors )
- test on brain organoids
Skill level: #intermediate
https://youtu.be/BQoIozpBU5Y
Why?
Deal with First gen psychedelic issues:
- they were not created specifically to threat a particular disorder even if can do it with a certain efficacy
- they have cardiotoxicity related to 5ht2b mechanism
- long action duration length for therapy
New hopes and ideas:
- decouple halucenogetic from therapeutic effect
- potentially reaching even newer states of mind
- targetly engineered experience without so complex set and setting
What?
- Kanna alcaloids for premature ejaculation 😅
- BPL-003 for Treatment Resistant Depression (TRD).
- IHCH-7113 Non halucenogetic psychedelic for depression
- Ele-101 for depression and Alcohol Use Disorder (AUD).
How?
1. AI assisted search
- Predictive AI. Train on structure to properties (need big dataset of both)
- Generative AI. Evolutionary machines
2. Natural compounds search and enchantment
- Research existing less popular natural compounds rom indigenous communities
- Enchance properties (Increase a half life, change blood barrier penetration, etc..
3. Future approaches
- computational chemistry (compounds VS receptors )
- test on brain organoids
Skill level: #intermediate
https://youtu.be/BQoIozpBU5Y
YouTube
The Next Generation of Psychedelic Drugs
We all know about LSD, magic mushrooms, and MDMA. But what about BPL-003, IHCH-7113, and ELE-101? Since psychedelic drugs may soon become available for medicinal use, many companies have sought to develop original psychedelic compounds, which can then be…
🤩1
Don't waste your time looking at Starship launch. Check this. Q&A with first DMTX Psychenauts 💥
It promises to be a revolutionary moment in the history of psychedelic exploration. Like NASA ventures into space, Noonautics is embarking on a mission into the depths of the human psyche, navigating the alien landscape of the DMT experience.
Esteemed writer and researcher, Graham Hancock, will preside over the panel in collaboration with the renowned DMT expert, Dr. Andrew Gallimore. The panel will feature the brave explorers of Imperial College London’s recent groundbreaking Extended DMT research: Carl Hayden Smith, Jack Allocca, Alexander Beiner, and Anton Bilton, who will illuminate the audience with their personal narratives of traversing the extended DMT state.
Drawing parallels with the Search for Extraterrestrial Intelligence (SETI), the focus of the discourse will be on the profound encounters with DMT entities.
Just as SETI deciphers signals from distant stars, our panelists will unravel and interpret their experiences in the DMT realms, potentially reshaping our understanding of reality.
Skill level: #advanced
https://noonautics.org/etn/dmtx-panel/
It promises to be a revolutionary moment in the history of psychedelic exploration. Like NASA ventures into space, Noonautics is embarking on a mission into the depths of the human psyche, navigating the alien landscape of the DMT experience.
Esteemed writer and researcher, Graham Hancock, will preside over the panel in collaboration with the renowned DMT expert, Dr. Andrew Gallimore. The panel will feature the brave explorers of Imperial College London’s recent groundbreaking Extended DMT research: Carl Hayden Smith, Jack Allocca, Alexander Beiner, and Anton Bilton, who will illuminate the audience with their personal narratives of traversing the extended DMT state.
Drawing parallels with the Search for Extraterrestrial Intelligence (SETI), the focus of the discourse will be on the profound encounters with DMT entities.
Just as SETI deciphers signals from distant stars, our panelists will unravel and interpret their experiences in the DMT realms, potentially reshaping our understanding of reality.
Skill level: #advanced
https://noonautics.org/etn/dmtx-panel/