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Psychedelic Consciousness ( ex Unstoppable Technologies)
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Brain therapy: Between Science and Businesses

Psychedelic Consciousness research: DMT, LSD, MDMA, 5MEO-DMT, Ketamine, Psilocilybin, Ibogaine...

#Psychedelics #Consciousness #Neuroscience
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HPPD or hallucinogen persisting perception disorder.

Just recently though if there are any good studies on this "flashbacks" phenomenon and here they are:

"One of the most notable findings was the correlation between first-time psychedelic use and an increase in unusual visual experiences. Participants who had never before used psychedelics but did so during the study period reported a greater increase in these experiences than individuals who had used psychedelics previously. This suggests that naivety to psychedelics may predispose individuals to more pronounced visual disturbances, highlighting a potential area of concern for first-time users


https://www.psypost.org/2024/02/psychedelic-use-linked-to-increased-risk-of-unusual-visual-experiences-221224
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Brain organoids breakthrough 😊


"Scientists have created brain “organoids” for years, but there are limitations to the tiny, lab-grown cultures. One of the most frustrating issues is a lack of control over their design, which often limits an organoid’s functionality and use. Although researchers long suspected 3D-printing could offer a solution, the workaround has so far proven difficult and ineffective. A new production breakthrough, however, could solve the longstanding barrier, and one day offer new ways of exploring treatment for diseases such as Parkinson’s and Alzeheimer’s."

And we will be finally able to test psychedelics on organoids 😊


https://www.popsci.com/science/3d-printed-brain-tissue/
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Psychedelics and Sex ❤️

14th February is close, plan your plans accordingly 😘

These are the findings of the first known scientific investigation into the effects of psychedelics on sex by Imperial College London. questionnaire responses from almost 300 people before and after a psychedelic experience.

By combining responses from two groups – people taking psychedelics for recreational or wellness/ceremonial purposes, as well as a small group from a clinical trial assessing psylocibin (the compound found in magic mushrooms) for depression – they were able to investigate how the experience influenced a range of aspects relating to sexual functioning.


The analysis reveals that on average, people reported improvements across a range of areas of sexual function up to six months after their psychedelic experience, including their enjoyment of sex, sexual arousal, satisfaction with sex, attraction to partner, their own physical appearance, communication, and their sense of connection.



https://www.imperial.ac.uk/news/251313/psychedelic-experiences-linked-with-improved-sexual/
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Sovereign funds looking to invest in Psychedelics 🥳

January was the second-highest month on record for funding of the psychedelics sector

Groups seeking to harness mind-altering substances including MDMA, psilocybin mushrooms, pictured at right, and 5-MeO-DMT raised at least $163mn across five deals in January

Sovereign wealth funds Temasek and Mubadala in talks to fund biotech groups harnessing mind-altering substances!

This is huge 😎




https://www.ft.com/content/4a2e856c-4736-4b8b-9323-583bb1dbe8f4
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DMT research must be legal 👊


"The reality that we experience, waking reality is marely a fraction of consciousness states that exist and if we prevent ourselves from studying those altered states of consciousness we will never have a complete understanding of the universe."  

https://youtu.be/LFnCwXPjSCk?si=sqchEfYs4p1B1Omn
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LSD, Homosexuality, WW2, Mk ultra, Weekend's history reading

"Tripping on Utopia: Margaret Mead, the Cold War, and the Troubled Birth of Psychedelic Science"

Looks like a new amazing book about psychedelics.😀


Margaret Mead was among the most famous scientists of the 20th century. Despite this, however, her role in the early history of psychedelic research has gone strangely unnoticed.
In this excerpt from my new book Tripping on UtopiaMargaret Mead, recently returned from months of anthropological fieldwork studying an apocalyptic religious movement known as the Noise on the remote island of Manus, becomes involved in the early LSD experiments of Harold Alexander Abramson—and begins planning to take the drug herself.

Mead’s most important source for information about psychedelics at this time was Dr. Harold Abramson, an allergist and expert in “psychosomatic” illnesses. Among other things, Abramson had shared with her the results of an LSD trial that resulted in what he called “loss of fear of homosexuality”: a woman racked by anxiety over her suspicion that she might be a lesbian had, under the drug, resolved her fears. Mead, who was in a committed, yearslong relationship with fellow anthropologist Rhoda Métraux by this time, absorbed this information with great interest. Perhaps LSD could speed up the rate at which global culture adapted to rapid change. Perhaps, as she wrote to herself in June 1954, the drug could be a “short cut” for pulling society “away from mysticism and escape.”


https://slate.com/news-and-politics/2024/02/tripping-on-utopia-book-lsd-psychedelics-history.html
Psychedelic facilitator requirements 😎


In the wake of psychedelic legalization in Colorado, a state board is outlining proposed training requirements for psychedelic "facilitators."

36 pages PDF is attached

https://www.9news.com/article/news/health/colorado-releases-proposed-rules-for-psychedelic-therapy-guides/73-4febfab5-e298-46fb-9f28-bd6768eb86c9
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Breaking: Group MDMA therapy trail launched in Israel.

The first cohort of October 7 victims started today by MAPS Israel.
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MAPS-Integration-Workbook.pdf
1.2 MB
Psychedelic integration guide 🔥

MAPS just released a new Psychedelics Integration guide. So far it's probably the best document in this area.
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Have Anxiety? Take LSD🤪

LSD now officially and efficiently can help with anxiety with only 100ug dose. What do I think? Hmmm. Yes, god damn it, we already know it 😂.

Some history facts:

2013 breakthrough FDA for Ketamine
2017 breakthrough FDA for MDMA
2018 breakthrough FDA for Psilocybin
2024 breakthrough FDA for LSD 😎<- we are here


"breakthrough designation is a recognition that a drug has demonstrated evidence of clinical efficacy in meeting an unmet medical need with morbidity and mortality associated with it,”

MindMed plans to hold an End-of-Phase 2 meeting with the U.S. Food & Drug Administration (FDA) in the first half of 2024 and initiate its Phase 3 clinical program in the second half of 2024


https://www.businesswire.com/news/home/20240307733599/en/
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New research on LSD Microdosing

Let it be the week of LSD 🤪

It was found that 26 micrograms of LSD  increased brain complexity by about 12 percent compared to a placebo, without altering consciousness.


The trials were repeated in two further groups, one with moderate (7.5 mg) and high (15 mg) doses of tetrahydrocannabinol (THC) from cannabis and one with medical methamphetamine at doses of 10 mg and 20 mg. In these experiments, THC, but not methamphetamine, affected consciousness at high doses.


The team's analysis of all the trials found only the 26-microgram dose of LSD had a significant effect on neural complexity, increasing it by approximately 12 percent on average when compared to the placebo"


I've personally found 50 micrigram dose very effective for a variety of things from self-healing and meditation to sex and learning new skills. However i tried this microdosing size of approximately 20 mcg just few times and it's definitely a big room for exploring the best application for such dose. 

Will soon write some guides on LSD mini-dosing 😁



https://www.sciencealert.com/tiny-doses-of-lsd-boost-unique-signals-in-the-human-brain
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150m$ for Mushrooms startup 🙃

Cybin Announces Closing of the Oversubscribed Private Placement of U.S. $150 Million

The net proceeds of the Private Placement are expected to be used for certain Phase 3 drug development activities for CYB003, working capital and general corporate purposes. CYB003, is a proprietary deuterated psilocybin analog in development for the potential treatment of Major Depressive Disorder ("MDD"). If approved by the U.S. Food and Drug Administration (the "FDA"), CYB003 would be the first known adjunctive psychedelic-based therapeutic for the treatment of MDD.


https://finance.yahoo.com/news/cybin-announces-closing-oversubscribed-private-155300089.html
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How I ate 40g of Mushrooms or measuring shrooms dose.

Actually this new research on measuring Psilocilybin in mushrooms is quite important. I've recently eaten 40gramms of some mushrooms which were offered to me as one dose.

I was a bit shocked as usually it should be 10-20 times less for one dose. But as a curious researcher I gave it a try 😅.

As you can see I'm still here and alive, though I had some conversations with entities 🙃. But subjustively it was similar to one dose.

So back to the research:

New technique measures psilocybin potency of mushrooms

Using 
liquid chromatography with tandem mass spectrometry, Schug and colleagues were able to extract and measure the strength of the mushrooms.

https://phys.org/news/2024-03-technique-psilocybin-potency-mushrooms.html
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Psychedelic digest march 2024.

Sorry, sorry I spent a month in Ubud and barely had time to post on a daily basis,but I carefully read all important news and here are the top ones for you and it's not a joke 🤣

Top important psychedelic news from Market, Research, Religion, Education, Industry,  Investment and Government. 


# Top Psychedelic Religion news


First Church in USA in the way to "legalize" the use of Ayahuasca 

https://www.chronline.com/stories/psychedelic-washington-church-working-toward-legal-immunity-to-consume-ayahuasca,335768?


# Top Psychedelics Education

Minor degree in Psychedelics opened in University of Boulder

https://www.9news.com/video/news/education/naropa-university-boulder-minor-psychedelics-mushrooms/73-5c670769-61a4-4ab3-8e49-0bd1aa584474

As well is in Naropa university! Wow! Two programs in one month

https://finance.yahoo.com/news/naropa-university-launches-pioneering-psychedelic-113400650.html

How to check quickly what is true and what is bullshit in Psychedelics

https://www.psychologytoday.com/us/blog/being-awake-better/202403/8-ways-to-learn-about-psychedelics


#Top psychedelic clinical trials

Psyched's intranasal 5-MEO-DMT passed phase 2 for Threatmen resident depression 😊

https://www.pharmabiz.com/NewsDetails.aspx?aid=168226&sid=2



#TOP Government psychedelic actions

https://www.marijuanamoment.net/u-s-company-offers-free-psychedelics-training-services-to-ukraine-health-professionals-to-treat-trauma-from-war-with-russia/

Fluence - a psychedelic Startup together with 
 Ukrainian Psychedelic Research Association (UPRA) and the U.S. nonprofit Heal Ukraine Trauma (HUT),  is providing free training materials for psychologists and medical doctors who are interested in incorporation psychedelics into their practices.

Unlike medical cannabis, psychedelics have not been legalized in Ukraine. Even so, more than 540 mental health professionals have already signed up for the program, Fluence said.

# Top Psychedelic Patent news

https://finance.yahoo.com/news/breakthrough-wellness-clearmind-medicines-psychedelic-115500300.html

Psychedelic Patent in China, that's interesting. 

MEAI is a new psychoactive molecule that reduces desire to consume alcoholic beverages and exerts a slight euphoric, alcohol-like experience with potential to change the lives of millions who struggle to drink in moderation. Clearmind’s MEAI-based flagship treatment focuses on Alcohol Use Disorder, which is incredibly common.


# Top Psychedelic Market news 

MOXY - new kid in Psychedelic renaissance

Mindstate Design Labs uses AI to find the best candidate for psychedelic assistant therapy.

Mindstate Design Labs has submitted its first IND, asking the FDA to greenlight a clinical trial for its lead asset targeting 5-MeO-MiPT, also known as moxy, a psychedelic selected from more than 70,000 “trip reports” to classify states of consciousness

Using large language models and natural language processing, Mindstate has built a platform that segments experiences by drug or psychedelic receptors. In some cases, the platform can visualize an experience, like color transformations

https://www.fiercebiotech.com/biotech/mindstates-first-ai-derived-psychedelic-heads-clinic
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Microdosing how to.

Ever considered microdosing?

Here is the great article on this topic which includes some history, research and guidelines on how to do it properly.

As for my experience, microdosing works. Even if it's a placebo effect, it's not that harmful and expensive to try if you suffer from long lasting depression or anxiety.

Also, Paul Stemets protocol with Psilocilybin niacin and lions mane seems like the best option, but it's all quite personal.


https://aeon.co/essays/a-nine-step-guide-to-a-sensible-microdosing-programme
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Moses was high on DMT 😁


Well, I'll just copy some parts of the article to give you an idea.


The podcaster then went on to add: “There’s a university in Israel – I think it’s the University of Jerusalem – that theorised that the Moses experience of the burning bush was a DMT experience.

When you say that ‘Moses saw the burning bush’, well, what kind of bush would burn that would give you a psychedelic experience? Well, the acacia tree.
“The acacia tree, which is very common to that area, is rich with DMT and how do you psychoactively acquire DMT? You smoke it.

“So you’re smoking this tree – this burning bush – and you’re seeing God, and God has brought you Ten Commandments of how to live life, which sounds like a lot of what you experience when you have the DMT experience. When you have that and you have these contact with the entities, they kind of give you guidelines on how to live.”

https://www.indy100.com/celebrities/joe-rogan-experience-bible-moses
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