Ja Perdole! New potent mushrooms hit like DMT 


"He consumed them fresh in a dose that would be equivalent to no more than 1.5 grams of the dried fungi, which is significantly below the amount generally required to “break through” and have a significant trip. “I knew that they had to be really powerful, because I couldn’t get out of my bed for about three or four hours. The first hour or two felt like a DMT experience.”


https://www.wired.com/story/breeding-stronger-magic-mushrooms/

DNA and Personalized Psychedelic Therapy

Wow, this is impressive. This report compiles a detailed DNA analysis, highlighting key genetic
variants that influence the efficacy, safety, metabolism, and receptor
affinity of psychedelic substances.

Leveraging PGxAI's expert interpretation,it delivers a comprehensive assessment of genetic responses forpersonalized psychedelic therapy.

Reality's Code Revealed by DMT 👾

Ok, seems like it's a breakthrough of the century or at least a great step towards more reliable experiments and overall public interest which will eventually lead to this breakthrough.

Danny Goler used a fat, diffracted laser beam ( barcode scanner) in a cross shape to reveal a "code", to see it you have to smoke a pretty heroic dose of DMT. The catch is that the same experiment was done multiple times by many people including sitting in the same room and all saw the same pattern. Theoretically it means that the things that we observe on DMT are "real" because "hallucinations" are the same for everyone. But this should be explores further and there are different opinions on that including a coment from the main DMT researcher Andrew Gillamore.


Here are the 6+ hours of content to dive into this trip
The original podcast in itself is the mind - blowing joy.


1. Original podcast with an author of experiment right from the moment where he discussed it https://www.youtube.com/watch?v=NJp2rASRKMc&t=779s
2. Comments for Andrew Gillamore "the DMT boss" https://youtu.be/3Hz6fab5NiE?si=f6rI-zx2b_XlOqTK
3. Response from tha author of an experiment https://youtu.be/ZGih-9FJyVc?si=xdcZiHiTb8yuCuC_
4. Article with thoughts on potential next experiments https://williamschwandt.substack.com/p/revealing-the-universe-code-by-reverse?utm_medium=web

I've just discovered it all and immediately sharing here and will spend some time diving deeper and writing more on this topic.

Waiting when Andreas from QRI as well as Josie from Psychonautwiki will record their thoughts.

Ketamine Reduces "Giving Up"


"Whole-brain imaging revealed ketamine overstimulated astrocytes, reducing their sensitivity to stress signals and making the fish more persistent. Similar mechanisms were confirmed in mice, suggesting astroglia play a crucial role in depression treatment."

Now I know what to do with burnouts 🤗

https://neurosciencenews.com/ketamine-astroglia-psychopharmacology-28264/

New insights on Ketamite function

Experience of Awe, is probably the main ingredient.

Awe is defined as a constellation of reactions that occur when a person encounters a “vast mystery” or experiences a need for “accommodation” to reorganize their knowledge structures to make sense of what they have encountered.

Interestingly, correlations between improvements in depression and the intensity of dissociative symptoms were negligible, suggesting that the experiences of awe might play a central role in ketamine’s antidepressant effects



https://www.psypost.org/experiences-of-awe-may-drive-ketamines-antidepressant-benefits/

Scientists discover quantum computing in the brain - The Brighter Side of News
https://www.thebrighterside.news/post/scientists-discover-quantum-computing-in-the-brain/

How Elon Musk’s billionaire Doge lieutenant took over the US’s biggest MDMA company | Technology | The Guardian
https://www.theguardian.com/technology/ng-interactive/2025/aug/28/elon-musk-antonio-gracias-mdma-psychedelics-company