California’s Latest Psychedelics Bill Dies in Committee - Psychedelic Alpha
Sad news, the bill was cancelled mostly because a budget constraint, which appears to be quite small 😔
"The Department of Consumer Affairs—which would have housed the Board of Regulated Psychedelic Facilitators—expects to see, based on boards of similar size, costs of nearly $2 million in the 2025-26 fiscal year and similar amounts in the following years. The Department further estimated that licensure fees would need to be “at least $4,960 biennially between initial applications, renewals, and other licensing categories.”
https://psychedelicalpha.com/news/californias-latest-psychedelics-bill-dies-in-committee
Sad news, the bill was cancelled mostly because a budget constraint, which appears to be quite small 😔
"The Department of Consumer Affairs—which would have housed the Board of Regulated Psychedelic Facilitators—expects to see, based on boards of similar size, costs of nearly $2 million in the 2025-26 fiscal year and similar amounts in the following years. The Department further estimated that licensure fees would need to be “at least $4,960 biennially between initial applications, renewals, and other licensing categories.”
https://psychedelicalpha.com/news/californias-latest-psychedelics-bill-dies-in-committee
Psychedelic Alpha
California’s Latest Psychedelics Bill Dies in Committee - Psychedelic Alpha
SB 1012, which would have established regulated, licensed psychedelic services in the state, has fallen victim to ‘suspense day’, where the state’s appropriations committees cull bills en masse.
Psychedelics playlist guide 🔥
Ever wondered how to make a great scientifically endorsed soundtrack for a psychedelic trip from start to finish?
This is the best guide I've seen so far 👌
https://maps.org/news/bulletin/creating-psilocybin-session-playlist/
Ever wondered how to make a great scientifically endorsed soundtrack for a psychedelic trip from start to finish?
This is the best guide I've seen so far 👌
https://maps.org/news/bulletin/creating-psilocybin-session-playlist/
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Why FDA Panel Rejected MDMA Therapy—And What’s Next For Psychedelic Medicine
The panel cited a number of issues around the credibility of the data and research practices, which were also addressed in a paper published by the non-profit Institute for Clinical and Economic Review (ICER) in March. The report highlighted “substantial concerns about the validity of the results.”
This included the blinding of the study—most patients correctly identified that they had been given MDMA—and “very strong prior beliefs” about the benefits of the treatment among both participants and therapists, which “raise concerns about bias.”
https://www.forbes.com/sites/sarahsinclair/2024/06/13/why-fda-panel-rejected-mdma-therapy-and-whats-next-for-psychedelic-medicine/
The panel cited a number of issues around the credibility of the data and research practices, which were also addressed in a paper published by the non-profit Institute for Clinical and Economic Review (ICER) in March. The report highlighted “substantial concerns about the validity of the results.”
This included the blinding of the study—most patients correctly identified that they had been given MDMA—and “very strong prior beliefs” about the benefits of the treatment among both participants and therapists, which “raise concerns about bias.”
https://www.forbes.com/sites/sarahsinclair/2024/06/13/why-fda-panel-rejected-mdma-therapy-and-whats-next-for-psychedelic-medicine/
Forbes
Why FDA Panel Rejected MDMA Therapy—And What’s Next For Psychedelic Medicine
The decision has put a spotlight on the field—and those at the center of it—raising questions about the credibility of the research being conducted and the safety of those involved in the trials.
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AI Creativity VS Mephedrone Comedown and Addiction 🤯
How could these two topics be related? On the surface, they seem worlds apart. But I'm always searching for connections between seemingly unrelated areas, and this skill often proves useful in hacking and entrepreneurship.
Have you ever tried to write a book using AI? It's a completely new kind of pleasure. You’re both writing and reading simultaneously—essentially creating and consuming at the same time. Normally, you either enjoy creative works like going to the theater, visiting a museum, or reading a book, or you create something like a piece of art or an article. However, there are very few activities that let you blend both experiences almost simultaneously. Perhaps DJing offers a similar sensation.
Using AI for creativity—whether you're writing a book, composing a song, or creating art—introduces a new way to have fun, where you enjoy consuming and creating simultaneously. It’s a mind-blowing experience, and if you haven’t tried it yet, I highly recommend giving it a go just for fun.
Now, let’s move on to Mephedrone.
To start with the basics—and with a big simplification—most chemical drugs act as analogs of certain neurotransmitters. Neurotransmitters are molecules that bind to specific neurons in the brain and are correlated with particular reactions. For example, dopamine makes you feel more energized and motivated, and drugs like cocaine or amphetamine mimic dopamine because their molecules are similar. Serotonin, on the other hand, makes you feel happy and relaxed, and MDMA acts similarly because it resembles serotonin (again, I’m simplifying here).
For most drugs, there’s usually one main type of neurotransmitter that the drug mimics. After consumption, this creates an imbalance in one area of the brain. For example, after taking MDMA, you experience a huge deficit in serotonin for a few days, and this feeling is really hard to deal with. This often motivates you to take more of the drug to fill this neurotransmitter gap. However, since other neurotransmitters remain at normal levels, you can eventually recover—like calling your friends, hanging out, or reading a good book to slowly increase serotonin and return to normal life.
However, there are more addictive drugs, like Mephedrone. The most problematic aspect of Mephedrone is that it simultaneously acts like both serotonin and dopamine, and it does so very effectively. As you might imagine, the comedown from Mephedrone is much harsher and more complex. Since you’re depleted of both serotonin and dopamine at the same time, it’s much harder to pull yourself out of that state—you're unmotivated to do anything, and nothing gives you joy. It’s a pretty tough place to be, which is why many people get stuck in addiction.
Now, back to creativity. Since the creative process with AI offers both a space for consumption (which increases serotonin) and creation (which increases dopamine) with minimal effort—literally, you just need to talk to a chatbot—there’s a chance that this approach could help to deal with Memphedrone comedown and probably even help addicted people return to normal life as a part of overall therapy. It might even inspire them to create amazing art because, often, people with addictions have a lot to say. Unfortunately, due to life's circumstances, they may find themselves in difficult situations far from the ability to create, but if they will be able to do that I bet they will create a masterpieces.
How could these two topics be related? On the surface, they seem worlds apart. But I'm always searching for connections between seemingly unrelated areas, and this skill often proves useful in hacking and entrepreneurship.
Have you ever tried to write a book using AI? It's a completely new kind of pleasure. You’re both writing and reading simultaneously—essentially creating and consuming at the same time. Normally, you either enjoy creative works like going to the theater, visiting a museum, or reading a book, or you create something like a piece of art or an article. However, there are very few activities that let you blend both experiences almost simultaneously. Perhaps DJing offers a similar sensation.
Using AI for creativity—whether you're writing a book, composing a song, or creating art—introduces a new way to have fun, where you enjoy consuming and creating simultaneously. It’s a mind-blowing experience, and if you haven’t tried it yet, I highly recommend giving it a go just for fun.
Now, let’s move on to Mephedrone.
To start with the basics—and with a big simplification—most chemical drugs act as analogs of certain neurotransmitters. Neurotransmitters are molecules that bind to specific neurons in the brain and are correlated with particular reactions. For example, dopamine makes you feel more energized and motivated, and drugs like cocaine or amphetamine mimic dopamine because their molecules are similar. Serotonin, on the other hand, makes you feel happy and relaxed, and MDMA acts similarly because it resembles serotonin (again, I’m simplifying here).
For most drugs, there’s usually one main type of neurotransmitter that the drug mimics. After consumption, this creates an imbalance in one area of the brain. For example, after taking MDMA, you experience a huge deficit in serotonin for a few days, and this feeling is really hard to deal with. This often motivates you to take more of the drug to fill this neurotransmitter gap. However, since other neurotransmitters remain at normal levels, you can eventually recover—like calling your friends, hanging out, or reading a good book to slowly increase serotonin and return to normal life.
However, there are more addictive drugs, like Mephedrone. The most problematic aspect of Mephedrone is that it simultaneously acts like both serotonin and dopamine, and it does so very effectively. As you might imagine, the comedown from Mephedrone is much harsher and more complex. Since you’re depleted of both serotonin and dopamine at the same time, it’s much harder to pull yourself out of that state—you're unmotivated to do anything, and nothing gives you joy. It’s a pretty tough place to be, which is why many people get stuck in addiction.
Now, back to creativity. Since the creative process with AI offers both a space for consumption (which increases serotonin) and creation (which increases dopamine) with minimal effort—literally, you just need to talk to a chatbot—there’s a chance that this approach could help to deal with Memphedrone comedown and probably even help addicted people return to normal life as a part of overall therapy. It might even inspire them to create amazing art because, often, people with addictions have a lot to say. Unfortunately, due to life's circumstances, they may find themselves in difficult situations far from the ability to create, but if they will be able to do that I bet they will create a masterpieces.
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Psychedelic Epiphany 101
Im sorry for the rare posts, but this is a new and definitely a very interesting and highly recommended video on various psychedelic "insights" that you might experience from the amazing Josie Kins, a founder of PsychonautWiki
I'll be very happy if you could share in the comments how many of them you personally experienced and what your thoughts are.
https://youtu.be/RIin9sOMzIg?si=_8lg52Ed2FEeWDl7
Im sorry for the rare posts, but this is a new and definitely a very interesting and highly recommended video on various psychedelic "insights" that you might experience from the amazing Josie Kins, a founder of PsychonautWiki
I'll be very happy if you could share in the comments how many of them you personally experienced and what your thoughts are.
https://youtu.be/RIin9sOMzIg?si=_8lg52Ed2FEeWDl7
YouTube
The Ultimate Psychedelic Realizations Tier List
Merch: https://multidimensional.market
Patreon (provides discord server access): https://patreon.com/josiekins
Original animated assets and primary video editing by @hypnagogist-art
Scripted section writing and primary audio editing by @emilykins
Select…
Patreon (provides discord server access): https://patreon.com/josiekins
Original animated assets and primary video editing by @hypnagogist-art
Scripted section writing and primary audio editing by @emilykins
Select…
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MDMA Space Therapy 😇
Imagine this: you’ve lived half your life in some cozy, familiar place, where everything – every café corner, every park bench – is tied to some soft, nostalgic glow. Even the bad stuff fades away, gets filtered through the sieve of time, and you’re left with mostly pleasant, or at least tolerable, memories. That park where you dropped your phone in the fountain? It’s a funny story now. The awkward date at that restaurant? Kinda cute in hindsight.
Then you move. New city. New life. And usually not that easy move. But wait. This isn’t the charming, memory-filled landscape of your past. This new place? It’s a chaos of weird, confusing experiences that hit like a constant loop of *"WTF is this life?"*. Every corner feels cursed. Here’s the spot where you spiraled into existential dread all winter, binge-watching *“The Office”* while questioning the meaning of human existence. Over there, the soulless government building where you were stuck in a Kafkaesque loop of paperwork, feeling like you’d traded your soul for a queue number. The park? Oh, that’s where you had an argument with someone who is now part of your list of people you actively avoid. And don’t even start on the language classes – the ulcer-inducing struggle of learning a new language, leaving you somewhere between confused and hopeless.
Everywhere you turn? It’s another reminder that this city sucks.
But here’s the kicker: what if the problem isn’t the city? What if it’s your brain? Neuroscience tells us that our environments become emotionally charged through the process of *associative learning*. That means if you’re miserable when you walk down a certain street, your brain locks that misery into the geography like a save point in a crappy video game.
Enter MDMA Space Therapy™. Yes, you heard me. Science to the rescue with a little sprinkle of serotonin magic. Research shows that MDMA, is being studied for its therapeutic effects, especially in rewiring traumatic associations. So what if, and hear me out here, instead of trudging through your new city full of dread and loathing, you preloading or post-cleaning your exploration with a fresh cocktail of dopamine and serotonin?
The park where you once fought with that jerk? Wow, the trees are whispering, and everyone’s energy feels connected. The language class that made you want to rip your hair out? *You’re learning the most beautiful words ever crafted by humanity!*
I know, I know. It sounds ridiculous, right? But this is where we lean on the therapeutic power of neuroplasticity. Your brain can change. It’s malleable. So, by associating new, positive experiences (enhanced with a little chemically-induced joy) to the places in your new city, you could effectively *re-wire* how your brain views your surroundings. You’re not erasing the bad stuff; you’re just... remixing it.
Of course, this isn’t exactly a *prenoscription*. Let’s not forget the legal and health caveats of MDMA. But hey, a long walk, some mindful breathing, maybe even a good playlist? That could work too, it actually can have the same acronym MDMA: *Massive Dose of Mindful Awareness*. ;)
Welcome to MDMA Space Therapy, where you don’t have to move to a new city to leave your emotional baggage behind—you just have to get your brain to let go of the suitcase!
Imagine this: you’ve lived half your life in some cozy, familiar place, where everything – every café corner, every park bench – is tied to some soft, nostalgic glow. Even the bad stuff fades away, gets filtered through the sieve of time, and you’re left with mostly pleasant, or at least tolerable, memories. That park where you dropped your phone in the fountain? It’s a funny story now. The awkward date at that restaurant? Kinda cute in hindsight.
Then you move. New city. New life. And usually not that easy move. But wait. This isn’t the charming, memory-filled landscape of your past. This new place? It’s a chaos of weird, confusing experiences that hit like a constant loop of *"WTF is this life?"*. Every corner feels cursed. Here’s the spot where you spiraled into existential dread all winter, binge-watching *“The Office”* while questioning the meaning of human existence. Over there, the soulless government building where you were stuck in a Kafkaesque loop of paperwork, feeling like you’d traded your soul for a queue number. The park? Oh, that’s where you had an argument with someone who is now part of your list of people you actively avoid. And don’t even start on the language classes – the ulcer-inducing struggle of learning a new language, leaving you somewhere between confused and hopeless.
Everywhere you turn? It’s another reminder that this city sucks.
But here’s the kicker: what if the problem isn’t the city? What if it’s your brain? Neuroscience tells us that our environments become emotionally charged through the process of *associative learning*. That means if you’re miserable when you walk down a certain street, your brain locks that misery into the geography like a save point in a crappy video game.
Enter MDMA Space Therapy™. Yes, you heard me. Science to the rescue with a little sprinkle of serotonin magic. Research shows that MDMA, is being studied for its therapeutic effects, especially in rewiring traumatic associations. So what if, and hear me out here, instead of trudging through your new city full of dread and loathing, you preloading or post-cleaning your exploration with a fresh cocktail of dopamine and serotonin?
The park where you once fought with that jerk? Wow, the trees are whispering, and everyone’s energy feels connected. The language class that made you want to rip your hair out? *You’re learning the most beautiful words ever crafted by humanity!*
I know, I know. It sounds ridiculous, right? But this is where we lean on the therapeutic power of neuroplasticity. Your brain can change. It’s malleable. So, by associating new, positive experiences (enhanced with a little chemically-induced joy) to the places in your new city, you could effectively *re-wire* how your brain views your surroundings. You’re not erasing the bad stuff; you’re just... remixing it.
Of course, this isn’t exactly a *prenoscription*. Let’s not forget the legal and health caveats of MDMA. But hey, a long walk, some mindful breathing, maybe even a good playlist? That could work too, it actually can have the same acronym MDMA: *Massive Dose of Mindful Awareness*. ;)
Welcome to MDMA Space Therapy, where you don’t have to move to a new city to leave your emotional baggage behind—you just have to get your brain to let go of the suitcase!
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Ja Perdole! New potent mushrooms hit like DMT
"He consumed them fresh in a dose that would be equivalent to no more than 1.5 grams of the dried fungi, which is significantly below the amount generally required to “break through” and have a significant trip. “I knew that they had to be really powerful, because I couldn’t get out of my bed for about three or four hours. The first hour or two felt like a DMT experience.”
https://www.wired.com/story/breeding-stronger-magic-mushrooms/
"He consumed them fresh in a dose that would be equivalent to no more than 1.5 grams of the dried fungi, which is significantly below the amount generally required to “break through” and have a significant trip. “I knew that they had to be really powerful, because I couldn’t get out of my bed for about three or four hours. The first hour or two felt like a DMT experience.”
https://www.wired.com/story/breeding-stronger-magic-mushrooms/
WIRED
Psychedelic Mushrooms Are Getting Much, Much Stronger
Cultivators are turning to genetic sequencing and cellular-manipulation techniques to breed highly potent mushrooms—leaving some unprepared psychonauts in distress.
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PGxAI_Psychedelics_PGx_Sample.pdf
716.2 KB
DNA and Personalized Psychedelic Therapy
Wow, this is impressive. This report compiles a detailed DNA analysis, highlighting key genetic
variants that influence the efficacy, safety, metabolism, and receptor
affinity of psychedelic substances.
Leveraging PGxAI's expert interpretation,it delivers a comprehensive assessment of genetic responses forpersonalized psychedelic therapy.
Wow, this is impressive. This report compiles a detailed DNA analysis, highlighting key genetic
variants that influence the efficacy, safety, metabolism, and receptor
affinity of psychedelic substances.
Leveraging PGxAI's expert interpretation,it delivers a comprehensive assessment of genetic responses forpersonalized psychedelic therapy.
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Reality's Code Revealed by DMT 👾
Ok, seems like it's a breakthrough of the century or at least a great step towards more reliable experiments and overall public interest which will eventually lead to this breakthrough.
Danny Goler used a fat, diffracted laser beam ( barcode scanner) in a cross shape to reveal a "code", to see it you have to smoke a pretty heroic dose of DMT. The catch is that the same experiment was done multiple times by many people including sitting in the same room and all saw the same pattern. Theoretically it means that the things that we observe on DMT are "real" because "hallucinations" are the same for everyone. But this should be explores further and there are different opinions on that including a coment from the main DMT researcher Andrew Gillamore.
Here are the 6+ hours of content to dive into this trip
The original podcast in itself is the mind - blowing joy.
1. Original podcast with an author of experiment right from the moment where he discussed it https://www.youtube.com/watch?v=NJp2rASRKMc&t=779s
2. Comments for Andrew Gillamore "the DMT boss" https://youtu.be/3Hz6fab5NiE?si=f6rI-zx2b_XlOqTK
3. Response from tha author of an experiment https://youtu.be/ZGih-9FJyVc?si=xdcZiHiTb8yuCuC_
4. Article with thoughts on potential next experiments https://williamschwandt.substack.com/p/revealing-the-universe-code-by-reverse?utm_medium=web
I've just discovered it all and immediately sharing here and will spend some time diving deeper and writing more on this topic.
Waiting when Andreas from QRI as well as Josie from Psychonautwiki will record their thoughts.
Ok, seems like it's a breakthrough of the century or at least a great step towards more reliable experiments and overall public interest which will eventually lead to this breakthrough.
Danny Goler used a fat, diffracted laser beam ( barcode scanner) in a cross shape to reveal a "code", to see it you have to smoke a pretty heroic dose of DMT. The catch is that the same experiment was done multiple times by many people including sitting in the same room and all saw the same pattern. Theoretically it means that the things that we observe on DMT are "real" because "hallucinations" are the same for everyone. But this should be explores further and there are different opinions on that including a coment from the main DMT researcher Andrew Gillamore.
Here are the 6+ hours of content to dive into this trip
The original podcast in itself is the mind - blowing joy.
1. Original podcast with an author of experiment right from the moment where he discussed it https://www.youtube.com/watch?v=NJp2rASRKMc&t=779s
2. Comments for Andrew Gillamore "the DMT boss" https://youtu.be/3Hz6fab5NiE?si=f6rI-zx2b_XlOqTK
3. Response from tha author of an experiment https://youtu.be/ZGih-9FJyVc?si=xdcZiHiTb8yuCuC_
4. Article with thoughts on potential next experiments https://williamschwandt.substack.com/p/revealing-the-universe-code-by-reverse?utm_medium=web
I've just discovered it all and immediately sharing here and will spend some time diving deeper and writing more on this topic.
Waiting when Andreas from QRI as well as Josie from Psychonautwiki will record their thoughts.
YouTube
New DMT Experiment Finds 'Alien Code' Hidden in the Fabric of Reality | Danny Goler
Watch this episode ad free & uncensored on Patreon: https://patreon.com/dannyjones
Danny Goler created an experiment with DMT & laser beams that proves we exist in a computational reality and how this can lead to a deeper understanding of our existence.
…
Danny Goler created an experiment with DMT & laser beams that proves we exist in a computational reality and how this can lead to a deeper understanding of our existence.
…
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Ketamine Reduces "Giving Up"
"Whole-brain imaging revealed ketamine overstimulated astrocytes, reducing their sensitivity to stress signals and making the fish more persistent. Similar mechanisms were confirmed in mice, suggesting astroglia play a crucial role in depression treatment."
Now I know what to do with burnouts 🤗
https://neurosciencenews.com/ketamine-astroglia-psychopharmacology-28264/
"Whole-brain imaging revealed ketamine overstimulated astrocytes, reducing their sensitivity to stress signals and making the fish more persistent. Similar mechanisms were confirmed in mice, suggesting astroglia play a crucial role in depression treatment."
Now I know what to do with burnouts 🤗
https://neurosciencenews.com/ketamine-astroglia-psychopharmacology-28264/
Neuroscience News
Ketamine Reduces “Giving Up” by Targeting Brain Support Cells
Researchers have found that ketamine’s antidepressant effects target astroglia, a type of brain support cell, rather than neurons, challenging conventional views.
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New insights on Ketamite function
Experience of Awe, is probably the main ingredient.
Awe is defined as a constellation of reactions that occur when a person encounters a “vast mystery” or experiences a need for “accommodation” to reorganize their knowledge structures to make sense of what they have encountered.
Interestingly, correlations between improvements in depression and the intensity of dissociative symptoms were negligible, suggesting that the experiences of awe might play a central role in ketamine’s antidepressant effects
https://www.psypost.org/experiences-of-awe-may-drive-ketamines-antidepressant-benefits/
Experience of Awe, is probably the main ingredient.
Awe is defined as a constellation of reactions that occur when a person encounters a “vast mystery” or experiences a need for “accommodation” to reorganize their knowledge structures to make sense of what they have encountered.
Interestingly, correlations between improvements in depression and the intensity of dissociative symptoms were negligible, suggesting that the experiences of awe might play a central role in ketamine’s antidepressant effects
https://www.psypost.org/experiences-of-awe-may-drive-ketamines-antidepressant-benefits/
PsyPost
Experiences of awe may drive ketamine’s antidepressant benefits
Ketamine infusion induces feelings of awe, which may mediate its antidepressant effects. Stronger awe experiences were linked to greater, longer-lasting depression symptom improvements, independent of dissociative symptoms
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Scientists discover quantum computing in the brain - The Brighter Side of News
https://www.thebrighterside.news/post/scientists-discover-quantum-computing-in-the-brain/
https://www.thebrighterside.news/post/scientists-discover-quantum-computing-in-the-brain/
The Brighter Side of News
Quantum computing occurs naturally in the human brain, study finds
New research shows that certain proteins rich in tryptophan—especially those found in brain cells—might act as networks for quantum computing.