Practical Psychedelic Mixology 🤡

List of polysubstance combinations - Wikipedia

Surprised that there is no name for Cannabis+Ketamine as I believe it's definitely something interesting happenings there. 🙊


https://en.wikipedia.org/wiki/List_of_polysubstance_combinations

Unlearning in AI and EMDR: Conceptual Parallels and Distinctions

The technique described by Microsoft researchers to make AI "forget" copyrighted material, conceptually intriguing. The method bears a resemblance to the therapeutic approach of EMDR, a recognized treatment for trauma.

Conceptual Similarities:

Targeted Erasure: Just as the researchers aim to erase specific knowledge (e.g., Harry Potter content) from the AI model, EMDR targets specific traumatic memories in patients, aiming to desensitize their emotional charge.

Fine-tuning: The AI technique involves fine-tuning the model to effectively erase specific content. Similarly, EMDR involves a structured eight-phase approach, where the therapist fine-tunes the process based on the patient's responses.

Adaptability: The AI's ability to adapt and "unlearn" mirrors the brain's plasticity, where neural pathways can be restructured, especially when traumatic memories are reprocessed in EMDR.

Differences:

Mechanism: While the AI technique employs a three-part method involving training on target data, replacing unique expressions, and fine-tuning on alternative predictions, EMDR uses bilateral stimulation (often in the form of guided eye movements) to help patients process traumatic memories.

Objective: The primary goal for AI is to ensure copyright compliance and adaptability. In contrast, EMDR aims to alleviate distress from traumatic memories and promote psychological healing.

Complexity: Human emotions and memories are multifaceted, with deep-rooted connections to various life experiences. AI models, although complex, operate on data and algorithms without the emotional depth inherent in human cognition.

In conclusion, while the conceptual framework of "unlearning" or "forgetting" is present in both the AI technique and EMDR, the underlying mechanisms, objectives, and complexities differ. It's fascinating to observe how principles of neuroscience and psychology can find echoes in the realm of artificial intelligence.

https://venturebeat.com/ai/researchers-turn-to-harry-potter-to-make-ai-forget-about-copyright-material/

“If anything, ibogaine is the hardest psychedelic to work with. But I’m here for the challenge.” - Deborah C. Mash

1. Ibogaine is a very promising psychedelic especially for curind opioid addiction. Fentanyl zombies, etc 😅
2. Ibogaine has a much harder path to FDA
3. VR is a great tool to configure set and setting while administering ibogaine in hospital (also valid for a Ketamine btw)

P.S. Great documentary to watch: NIGHT AND LIGHT: THE STORY OF IBOGA AND IBOGAINE


https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5saWJzeW4uY29tLzgxODk1L3Jzcw/episode/ZmE2NDc2YjctYmI3Mi00ZmM4LTkyZTktYzc0OTQwMTNlOTdh?ep=14

What if DMT entities are actually mind/conchesness viruses that we are only able to detect by running our brain in "disassembler mode" using DMT.

Thousands of programmable DNA-cutters found in algae, snails, and other organisms

Bye bye CRISPR , hello Fanzors🤟

https://phys.org/news/2023-10-thousands-programmable-dna-cutters-algae-snails.html

Ex–Tesla director gives Harvard $16 million to study psychedelics
https://qz.com/a-former-tesla-director-is-giving-harvard-16-million-t-1850932713

MDMA and critical periods.

"They hired me to learn autism in humans and I decided to give MDMA to octopuses 😅" - Gul Dolen. MD, pH. D.


1. Octopuses are super adaptive which means that their critical periods are like always on. Or can be turned on and off by some mechanisms and it's super important to learn it as it may help with humans .

2. People have critical periods for different systems when those systems are open to learning more.
One of the most knowm ones are language learning

But there is a theory that social interactions also have critical periods ( like I suppose usually from puberty till 20-ish )


3. Tested on mice . Waited for 48 hours , measured ability to learn from social environment. And adults started to learn from social environment. (Reopening of critical periods)

But! If mices don't have social interaction during a session they tend to not reopen those critical periods!


So. sychedelics are the "universal magic key" to re-open those critical periods but again, set and setting is vital

https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5saWJzeW4uY29tLzgxODk1L3Jzcw/episode/MGU3ZDc0NTYtOWExMS00MjJjLWFjZjEtZTA4YTUxMWNmMTFk?ep=14

Great discussion on latest MDMA assistant therapy results

1. MDMA - assisted therapy FDA approval is clother and closther
2. novasupport.org - great initiative to support victims of Nova festival
3. We all hope that Israel Psychedelic conference will happen on December as planned 🙏

https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5saWJzeW4uY29tLzgxODk1L3Jzcw/episode/MDJiZWExNGUtM2FmOC00MWQ2LThhOTMtOGU3NjZjMDk5M2E3?ep=14

A new must read in Psychedelics books.


"For Ten Trips, I took 10 different substances in 10 different contexts: DMT in a neuro-imaging research trial, magic mushrooms on a therapist’s couch, ayahuasca on the altar of a psychedelic church, LSD on the roundabout of a dual carriageway, mescaline half-way up Half-Dome, iboga at a plant-based retreat centre in the Bahamas, vaporised toad venom in some forest above Silicon Valley, and eventually, inexorably, to the indigenous cultures of Mexico, Peru and Columbia that have used the medicines for aeons: as someone sagely told me, with psychedelics, all roads eventually lead South."


https://www.esquire.com/uk/life/fitness-wellbeing/a45204988/why-i-wrote-a-first-hand-guide-to-the-new-age-of-psychedelics/

https://www.goodnewsnetwork.org/psychedelic-drugs-may-be-able-to-treat-brain-injuries-stimulating-new-neurons-to-replace-impaired-ones/

"Rats slowly infused with low doses of DMT after a stroke had fewer damaged tissues and more extensive recovery,” wrote National Geographic.

Shrooms in VR ? Yes , now officially make sense.

"Findings published this week in Frontiers in Psychiatry indicate the 20 subjects who took part in the small trial at Pacific Neuroscience Institute’s  Treatment & Research In Psychedelics Center – known as TRIP –overall were calmer and better able to ease into psilocybin-assisted therapy when they participated in the nature-themed immersive video experience during their treatment. "

https://smdp.com/2023/09/22/immersive-nature-videos-may-enhance-psychedelic-assisted-therapy-for-alcohol-addiction/

All we need is a Ketamine tonight.

It's the second podcast on the Ketamine-assisted therapy which makes me think that it's the best tool for adapting to changes, be it either some negative or extreme experiences like relocation or miss of relatives ( what was discussed in the previous one) as well as for positive changes like Accelerated growth, which was discussed in this episode.

I personally see a big future for Ketamine and those two podcasts are a great prove.
https://podcasts.google.com/feed/aHR0cHM6Ly9wbGFudG1lZGljaW5lcG9kY2FzdC5saWJzeW4uY29tL3Jzcw/episode/ZmFjMTg1ZjgtMGZkMS00MDcyLWI0YzAtYzk3MWQ4YjMxZWI3?ep=14

There is much better way to consume Ketamine.

"Psycheceutical’s patented NeuroDirect ketamine topical delivery system that is designed to target free nerve ending at the back of the neck. As such, the company believes that psychedelic medicine is delivered safely and effectively without hallucinogenic effects."



https://www.biopharma-reporter.com/Article/2023/09/26/Psycheceutical-Q-A-Could-topical-ketamine-transform-PTSD-treatment

Scientists Find Cannabis Compound Inside Totally Different Plant : ScienceAlert


Neto said chemical analysis had found "Trema" contains CBD but not THC, raising the possibility of an abundant new source of the former – one that would not face the legal and regulatory hurdles of cannabis, which continues to be outlawed in many places, including Brazil.


https://www.sciencealert.com/scientists-find-cannabis-compound-inside-totally-different-plant

Israel Psychedelic scene is growing 💥

https://allisrael.com/israeli-start-up-researches-use-of-psychedelics-to-treat-severe-pain-waits-for-fda-approval?__cf_chl_tk=XsdParILUIC3utjxr8vH4FE6nz5Gc8fnZcgeOhYmTUM-1697891741-0-gaNycGzNDNA

"Unlike other tech companies, Dreazen says the company is pursuing combining technology with an unconventional source: A Colorado River frog that secretes the substance 5-MeO-DMT from its gland, a naturally occurring tryptamine recognized for its psychedelic properties."

I hope they will aso provide a better way to consume it cuz those pipes are it's annoying 😂

Ibogaine + 5MEO = SolderFlip 💥

Wow, two most potent psychedelics together! I bet this shit can cure even zombies 🤡


The treatment included a combination of ibogaine hydrochloride, derived from the West African shrub iboga, and 5-MeO-DMT, a psychedelic substance secreted by the Colorado River toad

War time, war news, heh.

Each Special Ops veteran received a single oral ibogaine hydrochloride dose and, on a separate day, at least three incremental inhalation doses adding up to 50 milligrams of 5-MeO-DMT, also commonly called Five or Bufo. Preparation and reflection sessions preceded and followed each treatment. 



https://news.osu.edu/psychedelics-improve-mental-health-cognition-in-special-ops-veterans/

5 fucking billion fucking dollars for psychedelics research 🏦 ->💸💸💸

I've Heard this discussion in one of the recent podcasts and it looks like a mind blowing initiative, but I bet it will happen. 5B$ is even less that what was used to build a ChatGPT, so you can imagine what could be done if it will be used properly.

"Nonprofit in California has started a major signature campaign for a November 2024 ballot measure that aims to raise $5bn to fund clinical research on psychedelic-assisted treatments for veterans and first responders."



https://www.pharmaceutical-technology.com/news/treat-california-embarks-on-plan-to-earn-5bn-for-psychedelic-research/

New Magic mushrooms without Psylocibin but still magic 🤡

I won't fully believe untill I try but it's definitely worth covering:


After years of cultivating various species of fungi and experimenting with their genetic makeup, Psilomart was able to successfully breed five different strains of non-detect magic mushrooms that are free of illegal compounds, like psilocybin and psilocin, but contain high concentrations of other psychoactive alkaloids – Penis Envy, Golden Teachers, Alcabenzi, Mazatapec, and Burma.  

Sounds like a fucking bullshit but here is the catch:

There are many secondary alkaloids in magic mushrooms, like baeocystin, norbaeocystin, hydroxy-NMT, and many more. Some work synergistically with psilocybin to produce better effects, while others are hallucinogenic all on their own. For example, researchers theorize that baeocystin produces effects very similar to psilocybin, and it also metabolizes into psilocin in the human body, just like psilocybin does.


So, technically it's almost the same approach that we have with Weed, there are non-THC strains that contain HHC which also works but maybe less effective. And HHC is legal in Greece.

TLDR: if the legislation in some countries stated Psylocibin but not mushrooms, this thing may be kinda legal 🤡

https://cannadelics.com/2023/10/11/non-detect-magic-mushrooms-the-next-big-thing-in-legal-psychedelics/