MDMA and critical periods.

"They hired me to learn autism in humans and I decided to give MDMA to octopuses 😅" - Gul Dolen. MD, pH. D.


1. Octopuses are super adaptive which means that their critical periods are like always on. Or can be turned on and off by some mechanisms and it's super important to learn it as it may help with humans .

2. People have critical periods for different systems when those systems are open to learning more.
One of the most knowm ones are language learning

But there is a theory that social interactions also have critical periods ( like I suppose usually from puberty till 20-ish )


3. Tested on mice . Waited for 48 hours , measured ability to learn from social environment. And adults started to learn from social environment. (Reopening of critical periods)

But! If mices don't have social interaction during a session they tend to not reopen those critical periods!


So. sychedelics are the "universal magic key" to re-open those critical periods but again, set and setting is vital

https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5saWJzeW4uY29tLzgxODk1L3Jzcw/episode/MGU3ZDc0NTYtOWExMS00MjJjLWFjZjEtZTA4YTUxMWNmMTFk?ep=14

Great discussion on latest MDMA assistant therapy results

1. MDMA - assisted therapy FDA approval is clother and closther
2. novasupport.org - great initiative to support victims of Nova festival
3. We all hope that Israel Psychedelic conference will happen on December as planned 🙏

https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5saWJzeW4uY29tLzgxODk1L3Jzcw/episode/MDJiZWExNGUtM2FmOC00MWQ2LThhOTMtOGU3NjZjMDk5M2E3?ep=14

A new must read in Psychedelics books.


"For Ten Trips, I took 10 different substances in 10 different contexts: DMT in a neuro-imaging research trial, magic mushrooms on a therapist’s couch, ayahuasca on the altar of a psychedelic church, LSD on the roundabout of a dual carriageway, mescaline half-way up Half-Dome, iboga at a plant-based retreat centre in the Bahamas, vaporised toad venom in some forest above Silicon Valley, and eventually, inexorably, to the indigenous cultures of Mexico, Peru and Columbia that have used the medicines for aeons: as someone sagely told me, with psychedelics, all roads eventually lead South."


https://www.esquire.com/uk/life/fitness-wellbeing/a45204988/why-i-wrote-a-first-hand-guide-to-the-new-age-of-psychedelics/

https://www.goodnewsnetwork.org/psychedelic-drugs-may-be-able-to-treat-brain-injuries-stimulating-new-neurons-to-replace-impaired-ones/

"Rats slowly infused with low doses of DMT after a stroke had fewer damaged tissues and more extensive recovery,” wrote National Geographic.

Shrooms in VR ? Yes , now officially make sense.

"Findings published this week in Frontiers in Psychiatry indicate the 20 subjects who took part in the small trial at Pacific Neuroscience Institute’s  Treatment & Research In Psychedelics Center – known as TRIP –overall were calmer and better able to ease into psilocybin-assisted therapy when they participated in the nature-themed immersive video experience during their treatment. "

https://smdp.com/2023/09/22/immersive-nature-videos-may-enhance-psychedelic-assisted-therapy-for-alcohol-addiction/

All we need is a Ketamine tonight.

It's the second podcast on the Ketamine-assisted therapy which makes me think that it's the best tool for adapting to changes, be it either some negative or extreme experiences like relocation or miss of relatives ( what was discussed in the previous one) as well as for positive changes like Accelerated growth, which was discussed in this episode.

I personally see a big future for Ketamine and those two podcasts are a great prove.
https://podcasts.google.com/feed/aHR0cHM6Ly9wbGFudG1lZGljaW5lcG9kY2FzdC5saWJzeW4uY29tL3Jzcw/episode/ZmFjMTg1ZjgtMGZkMS00MDcyLWI0YzAtYzk3MWQ4YjMxZWI3?ep=14

There is much better way to consume Ketamine.

"Psycheceutical’s patented NeuroDirect ketamine topical delivery system that is designed to target free nerve ending at the back of the neck. As such, the company believes that psychedelic medicine is delivered safely and effectively without hallucinogenic effects."



https://www.biopharma-reporter.com/Article/2023/09/26/Psycheceutical-Q-A-Could-topical-ketamine-transform-PTSD-treatment

Scientists Find Cannabis Compound Inside Totally Different Plant : ScienceAlert


Neto said chemical analysis had found "Trema" contains CBD but not THC, raising the possibility of an abundant new source of the former – one that would not face the legal and regulatory hurdles of cannabis, which continues to be outlawed in many places, including Brazil.


https://www.sciencealert.com/scientists-find-cannabis-compound-inside-totally-different-plant

Israel Psychedelic scene is growing 💥

https://allisrael.com/israeli-start-up-researches-use-of-psychedelics-to-treat-severe-pain-waits-for-fda-approval?__cf_chl_tk=XsdParILUIC3utjxr8vH4FE6nz5Gc8fnZcgeOhYmTUM-1697891741-0-gaNycGzNDNA

"Unlike other tech companies, Dreazen says the company is pursuing combining technology with an unconventional source: A Colorado River frog that secretes the substance 5-MeO-DMT from its gland, a naturally occurring tryptamine recognized for its psychedelic properties."

I hope they will aso provide a better way to consume it cuz those pipes are it's annoying 😂

Ibogaine + 5MEO = SolderFlip 💥

Wow, two most potent psychedelics together! I bet this shit can cure even zombies 🤡


The treatment included a combination of ibogaine hydrochloride, derived from the West African shrub iboga, and 5-MeO-DMT, a psychedelic substance secreted by the Colorado River toad

War time, war news, heh.

Each Special Ops veteran received a single oral ibogaine hydrochloride dose and, on a separate day, at least three incremental inhalation doses adding up to 50 milligrams of 5-MeO-DMT, also commonly called Five or Bufo. Preparation and reflection sessions preceded and followed each treatment. 



https://news.osu.edu/psychedelics-improve-mental-health-cognition-in-special-ops-veterans/

5 fucking billion fucking dollars for psychedelics research 🏦 ->💸💸💸

I've Heard this discussion in one of the recent podcasts and it looks like a mind blowing initiative, but I bet it will happen. 5B$ is even less that what was used to build a ChatGPT, so you can imagine what could be done if it will be used properly.

"Nonprofit in California has started a major signature campaign for a November 2024 ballot measure that aims to raise $5bn to fund clinical research on psychedelic-assisted treatments for veterans and first responders."



https://www.pharmaceutical-technology.com/news/treat-california-embarks-on-plan-to-earn-5bn-for-psychedelic-research/

New Magic mushrooms without Psylocibin but still magic 🤡

I won't fully believe untill I try but it's definitely worth covering:


After years of cultivating various species of fungi and experimenting with their genetic makeup, Psilomart was able to successfully breed five different strains of non-detect magic mushrooms that are free of illegal compounds, like psilocybin and psilocin, but contain high concentrations of other psychoactive alkaloids – Penis Envy, Golden Teachers, Alcabenzi, Mazatapec, and Burma.  

Sounds like a fucking bullshit but here is the catch:

There are many secondary alkaloids in magic mushrooms, like baeocystin, norbaeocystin, hydroxy-NMT, and many more. Some work synergistically with psilocybin to produce better effects, while others are hallucinogenic all on their own. For example, researchers theorize that baeocystin produces effects very similar to psilocybin, and it also metabolizes into psilocin in the human body, just like psilocybin does.


So, technically it's almost the same approach that we have with Weed, there are non-THC strains that contain HHC which also works but maybe less effective. And HHC is legal in Greece.

TLDR: if the legislation in some countries stated Psylocibin but not mushrooms, this thing may be kinda legal 🤡

https://cannadelics.com/2023/10/11/non-detect-magic-mushrooms-the-next-big-thing-in-legal-psychedelics/

Year another donation to the industry

With the help of former Tesla (TSLA) director and Valor Equity Partners founder Antonio Gracias, Harvard University is getting back into psychedelics. Earlier this week, the university announced its creation of the interdisciplinary Study of Psychedelics in Society and Culture, courtesy of a $16 million donation from the Gracias Family Foundation.

P.S.
The total amount just from donations listed in the article are over $46.35 million.

https://observer.com/2023/10/antonio-gracias-psychedelic-studies-academic/

So emotional story

https://youtu.be/ROFoSE6tv1w?si=ZD3BmFP7O2xUwTMl

MDMA is too 2000th , welcome Methylone

https://www.standard.co.uk/news/health/methylone-drug-tested-ptsd-treatment-b1114003.html

What about Europe?


MEP Action for the Medical Use of Psychedelics is a cross-party platform on psychedelic medicines in the European Parliament. The MEP AG was established in May 2023 and the secretariat is jointly provided by PsychedelicsEUROPE and PAREA.

The group’s key objective is to accelerate the preparation of the regulatory landscape for psychedelic medicines in the EU Single Market. The group should also provide insights and recommendations for the regulators and policymakers for dossiers relevant to PAT, such as the above-mentioned revision of the EU Pharma Legislation or the emerging EU mental health strategy.

https://www.lucid.news/reforming-psychedelic-policy-for-450-million-europeans/

Ketamine therapy in New York in figures.


1. No official tally exists, but the nonprofit American Society of Ketamine Physicians, Psychotherapists and Practitioners lists seven members as practicing in New York City and 24 members listed in New York state overall. This number likely represents a low estimate of clinics given a quick internet search reveals way more on Yelp.

2. Intravenous ketamine treatment can be expensive, costing between $300 to $1,000 per session. Insurance does not generally cover these IVs for psychological conditions given their off-label prenoscriptions, but some providers accept out-of-network claims depending on a person’s individual coverage


3. Session lasts about 90 mimutes an admission and then talking therapy if required by patient. When the infusion ends, there’s a 10 to 15-minute stretch that Franke describes as the “washout period.” This is when the effects of ketamine are wearing off. Once this ends a clinician speaks to the patient about how they’re feeling and if they would rather reflect on the experience with them or in private. After the clinician determines that the patient is safe to leave, they are welcomed to a designated reflection and recovery space, where they can journal, read, draw, and gather their thoughts before going back into the world.

P.S. interested in alternatives in Israel ?;) DM

https://gothamist.com/news/what-to-know-before-you-try-psychedelic-ketamine-therapy-in-new-york-city

Shit happened, but it's a part of life

Or never drive a plane on shrooms because:

On Oct. 22, Alaska Airlines Flight 2059 left Paine Field in Everett, en route to San Francisco. Somewhere between Astoria, Oregon and Portland, Emerson is accused of trying to grab and pull two red fire handles that would have activated the plane’s emergency fire suppression system – cutting off fuel to the engines.

Yes, sooner or later some sort of event like this should happen. And there will be many more examples of bad examples with psychedelics. Buts I don't think we should worry about thisbcae and blame psychedelics it can be a bottle of bear or anything else that can lead to such effect. It's obvious that no matter what would be the legal status of psychedelics, it's not OK to drie a fucking plan on mushrooms, or at least if there are other people... and they are real 😅.




https://www.politico.com/news/2023/10/26/california-magic-mushroom-legalization-alaska-airlines-pilot-00123670