Psychedelic Consciousness ( ex Unstoppable Technologies) – Telegram
Psychedelic Consciousness ( ex Unstoppable Technologies)
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Brain therapy: Between Science and Businesses

Psychedelic Consciousness research: DMT, LSD, MDMA, 5MEO-DMT, Ketamine, Psilocilybin, Ibogaine...

#Psychedelics #Consciousness #Neuroscience
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Jews and Psychedelics what can be better 😅

One more Psychedelics book released this year, actually just a month ago, please stooop, how can I find so much time to read them all 😅

"Exile & Ecstasy: Growing Up with Ram Dass & Coming of Age in the Jewish Psychedelic Underground" by journalist/editor Madison Margolin.


In this article Margolin discusses why she wrote the memoir and the challenges she faces promoting this book at a time when the Israel/Hamas war rages on and antisemitism escalates worldwide.

"Margolin: I most enjoy writing about fun and colorful scenes, such as Hasidic psytrance parties or ayahuasca circles in upstate New York and Brooklyn. As far as what was problematic, I found it hard to write about the ‘underground’ while keeping it underground"


https://www.forbes.com/sites/irisdorbian/2023/11/17/a-journalists-memoir-explores-jewish-spirituality-with-psychedelics/?sh=42f5824b4f8c
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Dealers added Fentanyl to DMT 😢

Shiiiit there should be a special place in hell for such people.

What we believe is they’re trying to get people that are in the market for a psychedelic drug hooked on fentanyl and meth because they’ll take it thinking they want the psychedelic high and when they’re done, they’re hooked on the other drug,” said Fornoff.


https://www.ketv.com/article/attorney-arrested-in-largest-omaha-hallucinogen-bust/45886209
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ADHD + Microdosing = Mindfulness

New study on effects of Microdosing for ADHD people looks promising. 

Personally agree 😅

Point 1

"Participants completed various psychological assessments, including the Five Facet Mindfulness Questionnaire (FFMQ-15) for mindfulness and the Big Five Inventory (BFI-10) for personality traits. "


Point 2

"After 2 and 4 weeks of microdosing, participants reported increased levels of mindfulness compared to baseline. Specifically, they showed improvements in facets such as observation, denoscription, acting with awareness, non-judging of inner experience, 
and non-reactivity to inner experiences."


Point 3:

The bad thing is that there are participants with unpleasant experience, but wait, it means that Microdosing actually works ;) despite many attempts to call it placebo 😅

"But the study had some limitations, including a high dropout rate and potential bias due to participants who did not have a pleasant microdosing experience."


https://www.psypost.org/2023/11/microdosing-psychedelics-shows-promise-for-improving-mindfulness-in-adults-with-adhd-214715
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Ukraine is moving to right direction 🔥

Well it's in the government level now, looks very promising.

“Today we have 13 trauma therapists who can work with psychedelic assisted therapy. … We need 300,” 

Quote 1:

“We have this catastrophic challenge ahead,” Dmytro Gurin, a Ukrainian MP in President Volodymyr Zelenskyy's Servant of the People party and member of the country’s health committee, told a meeting of MEPs at the European Parliament on Tuesday. “And such challenges, they need bold decisions.”

Quote 2:

"Gurin is pitching that Ukraine's large population of trauma sufferers means the country could become a research center for MDMA-assisted therapies. He'd like EU financial support for Ukraine to develop a nationwide clinical trial to test MDMA-assisted therapy as a first treatment for trauma, rather than as a last resort, as is normally recommended.


Quote 3:

His solution is to set up a training center in the safe city of Uzhhorod, which borders Slovakia. From here, he said, Ukrainian therapists can be trained for Ukrainian cases: understanding the tortures and traumas of war.

https://www.politico.eu/article/ukraine-mp-dmytro-gurin-test-psychedelics-ptsd/
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Ketamine for heartbreak and Burnout

Sold😁
Shut up and take my money 🤑


"Emotional wounds like rejection and failure can be even more devastating than physical wounds, yet we don't give them the same time and attention,"


"I'm thrilled to combine my techniques for emotional first aid with ketamine therapy, which has been shown to increase neuroplasticity and help build emotional resilience"


Want some K therapy ? 😃

https://www.prnewswire.com/news-releases/mindbloom-launches-expert-led-psychedelic-therapy-for-heartbreak-burnout-and-more-302000235.html
Podcast on MDMA therapy and more 

Very insightful podcast with one of the "OG"'s of psychedelic therapy.

Some notes:

Trauma's have different effects (and approachesbto cure) at different ages

Ifs, and EMDR are the best psychotherapy methods so far before psychedelics

DSM was just created to somehow test drug research and should not be used as a diagnosis 

MDMA therapy also make you less tolerant to what you think other people think of you 

MDMA help people to be less identified with trauma. Instead of "I'm a Vietnam veteran" -> "I'm a human being experienced complex event."

MDMA therapy model super promising but practically very expensive( 36 hours of therapist's total) and may be not scalable. 

Group therapy with Ketamine might have more potential in reality for broader accessibility 

Somatic self awareness ( mind-body connection)  in 2 days before therapy can significantly decrease the dose especially for people who have low mind body connection.


https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5saWJzeW4uY29tLzgxODk1L3Jzcw/episode/NmU2NzNlNzQtZTZhYy00NWZiLTk3MWQtNWJlYTBhZDNjODg3?ep=14
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A new type of Psilocybin

So what is Drysdale’s secret weapon to bring even more therapeutic value to psilocybin? It’s a process called deuteration. It focuses on the hydrogen atoms in psilocybin. These atoms are very light and don’t stick very well to carbon, which is another atom in psilocybin. As a result, our bodies can easily breaks down the bonds between the hydrogen and carbon atoms. For many people, that means psilocybin gets cleared from the body too quickly, before it can have a therapeutic benefit.

In deuteration, scientists do something simple but ingenious: they replace the hydrogen atoms with a molecule called deuterium. It’s twice as heavy as hydrogen and forms tighter bonds with the carbon. Because these pairs are so rock-steady, they slow down the rate at which psilocybin is metabolized, so it has more sustained effects on our brains.

https://leaps.org/psilocybin/particle-1
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Beta-carbolines - WTF? 

You always leaning... I thought I Know at least most of the classes of Psychedelic compounds but here we are, another category that was new for me - beta-carbolines. I knew that it's a part of original Ayahuasca but haven't paid much attention yet. 

For me the most important is that they have effects exactly what I was looking for! Something that can help you to change your state into more calm and meditative but just a little bit. Weed and Ketamine are capable of doing it but still have other side effects for this particular task .

I wish that beta-carbolines are exactly what i was looking for. Will try 😁


https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5saWJzeW4uY29tLzgxODk1L3Jzcw/episode/ZDliNjZlNjUtMTg2Yi00NTQxLWEzOTItMDg3NTk2YTkyYzM2?ep=14
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Woooot😁

If all goes well, it’s possible that FDA approval for the prenoscription use of MDMA-assisted therapy for PTSD could take place around August 2024, with DEA rescheduling legally required to take place within 90 days after FDA approval

https://microdose.buzz/news/breaking-news-maps-files-new-drug-application-with-fda-for-mdma-assisted-therapy/
Hey fellow founders we have a "prenoscription"


"Investor Eddy Vaisberg, 33, told Business Insider ayahuasca could help founders gain better insights into themselves and others — and boost their creativity.

Thank you, mister investor, we know 😂, it can also help founders to quit this rat race ;) be careful. 


https://www.businessinsider.com/psychedelic-tea-ayahuasca-effects-founders-experiment-better-leaders-1heart-2023-12
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79% success in Psilocybin for MDD

Cybin published results of phase 2 for curing Major Depressive Disorder with its own Psilocybin derivative CYB003. 


"Next on the list for Cybin is submitting it to the FDA and requesting the federal agency an end-of-Phase 2 meeting for Q1 2024. With additional 12-week durability data from the Phase 2 study expected by next Q1 as well, Cybin anticipates -approval pending- to start recruiting for the Phase 3 study by the end of Q1 2024."

Seems like MDMA will be finally prescribed in 2024 and Psilocybin more likely will hit the market in 2025. 

https://www.benzinga.com/markets/cannabis/23/12/36055625/cybins-novel-psilocybin-topline-data-79-remission-in-major-depression-symptoms-whats-next
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Psychedelic Apps market

I know what you will do during Christmass holidays. 🤣
 
List of Prominent Players in the Mental Health Psychedelic Apps Market:

• Field Trip Health
• Mindleap,
• Homecoming
• Mindbloom,
Microdose.me,
• Polyfauna, PsycheDev
• Wavepaths
• TripApp
• Hypnoglyph
• Fraksl ,
• Lumenate
• Last Voyage
• PsyStation

https://www.openpr.com/news/3313112/mental-health-psychedelic-apps-market-latest-trends-and-future
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Neural Geometrodynamics

This research delves into a novel concept called "neural geometrodynamics," drawing parallels with general relativity in understanding the brain's functioning, particularly under the influence of psychedelics.

It focuses on three key timescales in the brain:

Fast Time Dynamics: These are immediate neural activities governed by differential equations and connectivity parameters. Think of this as the brain's immediate response to stimuli.

Slow Time Dynamics: Over this longer period, the brain's connectivity changes due to plasticity mechanisms. This is akin to the brain learning or adapting based on experiences.

Ultraslow Time Dynamics: This is where metaplasticity occurs - the brain's ability to change how it changes. It's a higher level of adaptation and learning.

Psychedelics, interestingly, flatten the brain's neural landscape. This flattening leads to a more chaotic and complex state of neural dynamics, as evidenced by neuroimaging studies. 

https://www.biorxiv.org/content/10.1101/2023.08.14.553258v2
Psychedelics as a Possible Cure for Color Blindness


Psilocybin may have temporarily modified the way color-blind patients perceive color. The data comes from a case report and the 2017 Global Drug Survey, although both studies have their flaws.

This phenomenon needs further investigation to determine its potential.

The subject had taken the Ishihara test, which consists of 21 plates with colored dots arranged in patterns to form numbers, before taking his initial dose. He scored 14 out of 21, indicating mild color blindness. He proceeded to retest himself 12 and 14 hours after consuming 5 grams of mushrooms  scoring 15 the first time and 18 the second time.

A score above 17 indicates normal vision, suggesting that he recovered his ability to distinguish colors. 

He retested himself eight days after his trip, scoring 19, and four months later, bumping down to 18 again.
 

https://psychedelicspotlight.com/why-do-we-feel-like-we-can-score-40-20-in-visual-acuity-on-low-doses-of-psychedelics/
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New Psychedelic Chatbot

Woooot, one more Chatbot for Psychonauts just released by Josie Kins. Great move towards harm reduction.

It can help to get proper information on substance usage. Examples in the comments, please share yours.

https://www.psyai.chat/
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