Psychedelic digest march 2024.

Sorry, sorry I spent a month in Ubud and barely had time to post on a daily basis,but I carefully read all important news and here are the top ones for you and it's not a joke 🤣

Top important psychedelic news from Market, Research, Religion, Education, Industry,  Investment and Government. 


# Top Psychedelic Religion news


First Church in USA in the way to "legalize" the use of Ayahuasca 

https://www.chronline.com/stories/psychedelic-washington-church-working-toward-legal-immunity-to-consume-ayahuasca,335768?


# Top Psychedelics Education

Minor degree in Psychedelics opened in University of Boulder

https://www.9news.com/video/news/education/naropa-university-boulder-minor-psychedelics-mushrooms/73-5c670769-61a4-4ab3-8e49-0bd1aa584474

As well is in Naropa university! Wow! Two programs in one month

https://finance.yahoo.com/news/naropa-university-launches-pioneering-psychedelic-113400650.html

How to check quickly what is true and what is bullshit in Psychedelics

https://www.psychologytoday.com/us/blog/being-awake-better/202403/8-ways-to-learn-about-psychedelics


#Top psychedelic clinical trials

Psyched's intranasal 5-MEO-DMT passed phase 2 for Threatmen resident depression 😊

https://www.pharmabiz.com/NewsDetails.aspx?aid=168226&sid=2



#TOP Government psychedelic actions

https://www.marijuanamoment.net/u-s-company-offers-free-psychedelics-training-services-to-ukraine-health-professionals-to-treat-trauma-from-war-with-russia/

Fluence - a psychedelic Startup together with 
 Ukrainian Psychedelic Research Association (UPRA) and the U.S. nonprofit Heal Ukraine Trauma (HUT),  is providing free training materials for psychologists and medical doctors who are interested in incorporation psychedelics into their practices.

Unlike medical cannabis, psychedelics have not been legalized in Ukraine. Even so, more than 540 mental health professionals have already signed up for the program, Fluence said.

# Top Psychedelic Patent news

https://finance.yahoo.com/news/breakthrough-wellness-clearmind-medicines-psychedelic-115500300.html

Psychedelic Patent in China, that's interesting. 

MEAI is a new psychoactive molecule that reduces desire to consume alcoholic beverages and exerts a slight euphoric, alcohol-like experience with potential to change the lives of millions who struggle to drink in moderation. Clearmind’s MEAI-based flagship treatment focuses on Alcohol Use Disorder, which is incredibly common.


# Top Psychedelic Market news 

MOXY - new kid in Psychedelic renaissance

Mindstate Design Labs uses AI to find the best candidate for psychedelic assistant therapy.

Mindstate Design Labs has submitted its first IND, asking the FDA to greenlight a clinical trial for its lead asset targeting 5-MeO-MiPT, also known as moxy, a psychedelic selected from more than 70,000 “trip reports” to classify states of consciousness

Using large language models and natural language processing, Mindstate has built a platform that segments experiences by drug or psychedelic receptors. In some cases, the platform can visualize an experience, like color transformations

https://www.fiercebiotech.com/biotech/mindstates-first-ai-derived-psychedelic-heads-clinic

Microdosing how to.

Ever considered microdosing?

Here is the great article on this topic which includes some history, research and guidelines on how to do it properly.

As for my experience, microdosing works. Even if it's a placebo effect, it's not that harmful and expensive to try if you suffer from long lasting depression or anxiety.

Also, Paul Stemets protocol with Psilocilybin niacin and lions mane seems like the best option, but it's all quite personal.


https://aeon.co/essays/a-nine-step-guide-to-a-sensible-microdosing-programme

Moses was high on DMT 😁


Well, I'll just copy some parts of the article to give you an idea.


The podcaster then went on to add: “There’s a university in Israel – I think it’s the University of Jerusalem – that theorised that the Moses experience of the burning bush was a DMT experience.

When you say that ‘Moses saw the burning bush’, well, what kind of bush would burn that would give you a psychedelic experience? Well, the acacia tree.
“The acacia tree, which is very common to that area, is rich with DMT and how do you psychoactively acquire DMT? You smoke it.

“So you’re smoking this tree – this burning bush – and you’re seeing God, and God has brought you Ten Commandments of how to live life, which sounds like a lot of what you experience when you have the DMT experience. When you have that and you have these contact with the entities, they kind of give you guidelines on how to live.”

https://www.indy100.com/celebrities/joe-rogan-experience-bible-moses

Dark side of Ketamine🫣

Highly recommend to listen, it's just 30 minutes, but here is TLDR:

In small doses ( about 25mg) Ketamine works more like a stimulant and affect dopamine system and that's what party people like and that's where ther eis a lot of abuse. In high doses (75mg+) it works as a dissociative, that's what therapists like, that's where you hardly can party, but can solve your psychological issues. 

In small doses it's actually more bad because that's where you can be highly dependant on it and at the same time you don't get any therapeutic effect. 


Other issues:

1. Bladder bleeding and cystitis. Very common if you use it regularly. 

2. If you overuse it you might have a depression ( lol, because it supposed to cure it ) so be careful, 6-8 sessions 2 times a week and then delay for few months
3. Don't mix ( especially with Coke) and don't do too much as you might have a cardiac arrest 

Overall if you do it properly, chances are very small, but as with any other drugs, don't overuse.


https://podcasts.google.com/feed/aHR0cHM6Ly9wbGFudG1lZGljaW5lcG9kY2FzdC5saWJzeW4uY29tL3Jzcw/episode/YTRmNTVlZjctMGVmMy00ZTU3LWJjNDQtNWQ3MTk5Y2Q0YmRk?ep=14

Psychedelics for Frontotemporal dementia 😎

Holy macaroni! I thought that this should work but haven't heard any evidence but and finally we have some clinical trials💪

New form on non-haluconogenic Psilocybin ->

https://www.psilera.com/psil006


https://baynews9.com/fl/tampa/news/2024/04/10/psilera-psychedelics-medical--

Pastor making 5m$ on psychedelics

Looks like I choose the wrong path, lol.


Pastor behind psychedelic San Francisco church raking in $5m a year supplying shrooms and weed to members claims drug-fueled worship can save people from fentanyl



https://www.dailymail.co.uk/news/article-13292963/dave-hodges-shrooms-weed-supplier-san-francisco-church.html

DMT vs Alzheimer's, 1:0 😍

The maze test results showed mice who had been given DMT were much better at finding the target area, improving the time it took them to do so after training, than the group who were administered saline solution. 

“These results suggested that chronic DMT treatment was sufficient to suppress cognitive decline of AD,” the study said. 


https://www.leafie.co.uk/news/dmt-treatment-prevention-alzheimers/

Psychedelics works better for old people 😁

Analysis of existing studies revealed that the drug had greater benefits among certain groups, including older people, finding that depression levels reduced further for every year older a patient was.


https://www.telegraph.co.uk/news/2024/05/02/magic-mushrooms-most-benefit-elderly-fighting-depression/

Can Dogs Trip Out? 

Ever wondered if your dog could get a buzz similar to your cat’s catnip high? Turns out, the idea isn’t as far-fetched as it seems! While catnip leaves dogs unimpressed, recent research is diving into the world of psychedelics for our canine companions.

Indigenous cultures like the Shuar and Quichua of Ecuador have been using psychoactive plants on their hunting dogs for ages, believing these substances sharpen their sense

Modern scientists are now exploring this fascinating concept. Dr. Carlo Siracusa from the University of Pennsylvania's Penn Psychedelic Collaborative is leading studies to understand how these drugs affect dogs.

Research suggests that psychedelics might enhance dogs' sensory perceptions by acting on serotonin receptors, much like they do in humans. A 2015 study highlighted that 43 different plant species used by the Shuar and Quichua could be boosting dogs' smell, hearing, and sight.

While the idea of enhancing your dog's senses sounds exciting, it's not all tail wags and rainbows. Dogs on psychedelics like psilocybin can show signs of distress: lack of coordination, aggression, overheating, and bizarre behaviors like running in circles or barking uncontrollably. There’s also a serious risk of serotonin syndrome, a potentially fatal condition from neurotransmitter overload.


https://www.inverse.com/health/dogs-pets-benefit-from-psychedelics

And now, Fish on Psychedelics 😎

Scientists at Weizmann Institute just unlocked the secrets of psychedelics using zebrafish. By bathing these little swimmers in psilocybin researchers tracked brain changes with cutting-edge microscopy and AI. Guess what? Fish on psychedelics showed less stress and wild new brain patterns, potentially paving the way for superior depression treatments.

Our optical imaging has revealed neural activity patterns in psilocybin-soaked fish that were similar to those seen by other labs in the mammalian brain exposed to psychedelics. This indicates that psilocybin exerts its influence on behavior through neural mechanisms in deep areas of the brain that have been conserved in evolution and are also found in mammals, including humans!

https://wis-wander.weizmann.ac.il/life-sciences/fish-under-influence-reveal-how-psychedelics-work

California’s Latest Psychedelics Bill Dies in Committee - Psychedelic Alpha


Sad news, the bill was cancelled mostly because a budget constraint, which appears to be quite small 😔


"The Department of Consumer Affairs—which would have housed the Board of Regulated Psychedelic Facilitators—expects to see, based on boards of similar size, costs of nearly $2 million in the 2025-26 fiscal year and similar amounts in the following years. The Department further estimated that licensure fees would need to be “at least $4,960 biennially between initial applications, renewals, and other licensing categories.”





https://psychedelicalpha.com/news/californias-latest-psychedelics-bill-dies-in-committee

Psychedelics playlist guide 🔥


Ever wondered how to make a great scientifically endorsed soundtrack for a psychedelic trip from start to finish?

This is the best guide I've seen so far 👌

https://maps.org/news/bulletin/creating-psilocybin-session-playlist/

Why FDA Panel Rejected MDMA Therapy—And What’s Next For Psychedelic Medicine

The panel cited a number of issues around the credibility of the data and research practices, which were also addressed in a paper published by the non-profit Institute for Clinical and Economic Review (ICER) in March. The report highlighted “substantial concerns about the validity of the results.”
This included the blinding of the study—most patients correctly identified that they had been given MDMA—and “very strong prior beliefs” about the benefits of the treatment among both participants and therapists, which “raise concerns about bias.”




https://www.forbes.com/sites/sarahsinclair/2024/06/13/why-fda-panel-rejected-mdma-therapy-and-whats-next-for-psychedelic-medicine/

AI Creativity VS Mephedrone Comedown and Addiction 🤯

How could these two topics be related? On the surface, they seem worlds apart. But I'm always searching for connections between seemingly unrelated areas, and this skill often proves useful in hacking and entrepreneurship.

Have you ever tried to write a book using AI? It's a completely new kind of pleasure. You’re both writing and reading simultaneously—essentially creating and consuming at the same time. Normally, you either enjoy creative works like going to the theater, visiting a museum, or reading a book, or you create something like a piece of art or an article. However, there are very few activities that let you blend both experiences almost simultaneously. Perhaps DJing offers a similar sensation.

Using AI for creativity—whether you're writing a book, composing a song, or creating art—introduces a new way to have fun, where you enjoy consuming and creating simultaneously. It’s a mind-blowing experience, and if you haven’t tried it yet, I highly recommend giving it a go just for fun.

Now, let’s move on to Mephedrone.

To start with the basics—and with a big simplification—most chemical drugs act as analogs of certain neurotransmitters. Neurotransmitters are molecules that bind to specific neurons in the brain and are correlated with particular reactions. For example, dopamine makes you feel more energized and motivated, and drugs like cocaine or amphetamine mimic dopamine because their molecules are similar. Serotonin, on the other hand, makes you feel happy and relaxed, and MDMA acts similarly because it resembles serotonin (again, I’m simplifying here).

For most drugs, there’s usually one main type of neurotransmitter that the drug mimics. After consumption, this creates an imbalance in one area of the brain. For example, after taking MDMA, you experience a huge deficit in serotonin for a few days, and this feeling is really hard to deal with. This often motivates you to take more of the drug to fill this neurotransmitter gap. However, since other neurotransmitters remain at normal levels, you can eventually recover—like calling your friends, hanging out, or reading a good book to slowly increase serotonin and return to normal life.

However, there are more addictive drugs, like Mephedrone. The most problematic aspect of Mephedrone is that it simultaneously acts like both serotonin and dopamine, and it does so very effectively. As you might imagine, the comedown from Mephedrone is much harsher and more complex. Since you’re depleted of both serotonin and dopamine at the same time, it’s much harder to pull yourself out of that state—you're unmotivated to do anything, and nothing gives you joy. It’s a pretty tough place to be, which is why many people get stuck in addiction.

Now, back to creativity. Since the creative process with AI offers both a space for consumption (which increases serotonin) and creation (which increases dopamine) with minimal effort—literally, you just need to talk to a chatbot—there’s a chance that this approach could help to deal with Memphedrone comedown and probably even help addicted people return to normal life as a part of overall therapy. It might even inspire them to create amazing art because, often, people with addictions have a lot to say. Unfortunately, due to life's circumstances, they may find themselves in difficult situations far from the ability to create, but if they will be able to do that I bet they will create a masterpieces. 

Trump about psychedelics at Lex Friedman podcast 🔥🔥🔥

Psychedelic Epiphany 101

Im sorry for the rare posts, but this is a new and definitely a very interesting and highly recommended video on various psychedelic "insights" that you might experience from the amazing Josie Kins, a founder of PsychonautWiki

I'll be very happy if you could share in the comments how many of them you personally experienced and what your thoughts are.

https://youtu.be/RIin9sOMzIg?si=_8lg52Ed2FEeWDl7

MDMA Space Therapy 😇

Imagine this: you’ve lived half your life in some cozy, familiar place, where everything – every café corner, every park bench – is tied to some soft, nostalgic glow. Even the bad stuff fades away, gets filtered through the sieve of time, and you’re left with mostly pleasant, or at least tolerable, memories. That park where you dropped your phone in the fountain? It’s a funny story now. The awkward date at that restaurant? Kinda cute in hindsight.

Then you move. New city. New life. And usually not that easy move. But wait. This isn’t the charming, memory-filled landscape of your past. This new place? It’s a chaos of weird, confusing experiences that hit like a constant loop of *"WTF is this life?"*. Every corner feels cursed. Here’s the spot where you spiraled into existential dread all winter, binge-watching *“The Office”* while questioning the meaning of human existence. Over there, the soulless government building where you were stuck in a Kafkaesque loop of paperwork, feeling like you’d traded your soul for a queue number. The park? Oh, that’s where you had an argument with someone who is now part of your list of people you actively avoid. And don’t even start on the language classes – the ulcer-inducing struggle of learning a new language, leaving you somewhere between confused and hopeless.

Everywhere you turn? It’s another reminder that this city sucks. 

But here’s the kicker: what if the problem isn’t the city? What if it’s your brain? Neuroscience tells us that our environments become emotionally charged through the process of *associative learning*. That means if you’re miserable when you walk down a certain street, your brain locks that misery into the geography like a save point in a crappy video game.

Enter MDMA Space Therapy™. Yes, you heard me. Science to the rescue with a little sprinkle of serotonin magic. Research shows that MDMA, is being studied for its therapeutic effects, especially in rewiring traumatic associations. So what if, and hear me out here, instead of trudging through your new city full of dread and loathing, you preloading  or post-cleaning  your exploration with a fresh cocktail of dopamine and serotonin?

The park where you once fought with that jerk? Wow, the trees are whispering, and everyone’s energy feels connected. The language class that made you want to rip your hair out? *You’re learning the most beautiful words ever crafted by humanity!*

I know, I know. It sounds ridiculous, right? But this is where we lean on the therapeutic power of neuroplasticity. Your brain can change. It’s malleable. So, by associating new, positive experiences (enhanced with a little chemically-induced joy) to the places in your new city, you could effectively *re-wire* how your brain views your surroundings. You’re not erasing the bad stuff; you’re just... remixing it.

Of course, this isn’t exactly a *prenoscription*. Let’s not forget the legal and health caveats of MDMA. But hey, a long walk, some mindful breathing, maybe even a good playlist? That could work too, it actually can have the same acronym  MDMA: *Massive Dose of Mindful Awareness*. ;)

Welcome to MDMA Space Therapy, where you don’t have to move to a new city to leave your emotional baggage behind—you just have to get your brain to let go of the suitcase!

Ja Perdole! New potent mushrooms hit like DMT 


"He consumed them fresh in a dose that would be equivalent to no more than 1.5 grams of the dried fungi, which is significantly below the amount generally required to “break through” and have a significant trip. “I knew that they had to be really powerful, because I couldn’t get out of my bed for about three or four hours. The first hour or two felt like a DMT experience.”


https://www.wired.com/story/breeding-stronger-magic-mushrooms/

DNA and Personalized Psychedelic Therapy

Wow, this is impressive. This report compiles a detailed DNA analysis, highlighting key genetic
variants that influence the efficacy, safety, metabolism, and receptor
affinity of psychedelic substances.

Leveraging PGxAI's expert interpretation,it delivers a comprehensive assessment of genetic responses forpersonalized psychedelic therapy.

Reality's Code Revealed by DMT 👾

Ok, seems like it's a breakthrough of the century or at least a great step towards more reliable experiments and overall public interest which will eventually lead to this breakthrough.

Danny Goler used a fat, diffracted laser beam ( barcode scanner) in a cross shape to reveal a "code", to see it you have to smoke a pretty heroic dose of DMT. The catch is that the same experiment was done multiple times by many people including sitting in the same room and all saw the same pattern. Theoretically it means that the things that we observe on DMT are "real" because "hallucinations" are the same for everyone. But this should be explores further and there are different opinions on that including a coment from the main DMT researcher Andrew Gillamore.


Here are the 6+ hours of content to dive into this trip
The original podcast in itself is the mind - blowing joy.


1. Original podcast with an author of experiment right from the moment where he discussed it https://www.youtube.com/watch?v=NJp2rASRKMc&t=779s
2. Comments for Andrew Gillamore "the DMT boss" https://youtu.be/3Hz6fab5NiE?si=f6rI-zx2b_XlOqTK
3. Response from tha author of an experiment https://youtu.be/ZGih-9FJyVc?si=xdcZiHiTb8yuCuC_
4. Article with thoughts on potential next experiments https://williamschwandt.substack.com/p/revealing-the-universe-code-by-reverse?utm_medium=web

I've just discovered it all and immediately sharing here and will spend some time diving deeper and writing more on this topic.

Waiting when Andreas from QRI as well as Josie from Psychonautwiki will record their thoughts.

Ketamine Reduces "Giving Up"


"Whole-brain imaging revealed ketamine overstimulated astrocytes, reducing their sensitivity to stress signals and making the fish more persistent. Similar mechanisms were confirmed in mice, suggesting astroglia play a crucial role in depression treatment."

Now I know what to do with burnouts 🤗

https://neurosciencenews.com/ketamine-astroglia-psychopharmacology-28264/